(Q42705953)

5 November 2017

title

The γH2AX assay for genotoxic and nongenotoxic agents: comparison of H2AX phosphorylation with cell death response (English)

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5 November 2017

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1

Teodora Nikolova

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5 November 2017

Mirek Dvorak

2

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5 November 2017

Fabian Jung

3

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5 November 2017

Isabell Adam

4

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5 November 2017

Elisabeth Krämer

5

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5 November 2017

Aslihan Gerhold-Ay

6

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5 November 2017

Bernd Kaina

7

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5 November 2017

publication date

17 April 2014

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5 November 2017

published in

Toxicological Sciences

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5 November 2017

volume

140

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5 November 2017

issue

1

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5 November 2017

page(s)

103-117

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Phosphorylation and rapid relocalization of 53BP1 to nuclear foci upon DNA damage

5 November 2017

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Validation of high-throughput genotoxicity assay screening using γH2AX in-cell western assay on HepG2 cells

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More than just a focus: The chromatin response to DNA damage and its role in genome integrity maintenance

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Mdc1 couples DNA double-strand break recognition by Nbs1 with its H2AX-dependent chromatin retention

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Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells

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Discrimination for genotoxic and nongenotoxic carcinogens by gene expression profiling in primary mouse hepatocytes improves with exposure time

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The alkaline comet assay: towards validation in biomonitoring of DNA damaging exposures

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Chloroethylnitrosourea-induced cell death and genotoxicity: cell cycle dependence and the role of DNA double-strand breaks, HR and NHEJ.

21 January 2018

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A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage

21 January 2018

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Processing of O6-methylguanine into DNA double-strand breaks requires two rounds of replication whereas apoptosis is also induced in subsequent cell cycles

21 January 2018

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Tumor suppressor p53 binding protein 1 (53BP1) is involved in DNA damage-signaling pathways

21 January 2018

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DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139

21 January 2018

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21 January 2018

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DNA damage-induced cell death: from specific DNA lesions to the DNA damage response and apoptosis

21 January 2018

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Automated scoring of lymphocyte micronuclei by the MetaSystems Metafer image cytometry system and its application in studies of human mutagen sensitivity and biodosimetry of genotoxin exposure

21 January 2018

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Evidence for a lack of DNA double-strand break repair in human cells exposed to very low x-ray doses

21 January 2018

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Fully automated interpretation of ionizing radiation-induced γH2AX foci by the novel pattern recognition system AKLIDES®.

21 January 2018

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p53 binding protein 1 (53BP1) is an early participant in the cellular response to DNA double-strand breaks

21 January 2018

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New developments in automated cytogenetic imaging: unattended scoring of dicentric chromosomes, micronuclei, single cell gel electrophoresis, and fluorescence signals.

21 January 2018

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Automated analysis of FISH-stained HER2/neu samples with Metafer

21 January 2018

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Quantitative detection of (125)IdU-induced DNA double-strand breaks with gamma-H2AX antibody

21 January 2018

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Regulation of DNA double-strand break repair pathway choice

21 January 2018

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Genotoxicity screening via the γH2AX by flow assay.

21 January 2018

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21 January 2018

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Measurement of DNA interstrand crosslinking in individual cells using the Single Cell Gel Electrophoresis (Comet) assay

21 January 2018

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MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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An automated scoring procedure for the micronucleus test by image analysis.

21 January 2018

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21 January 2018

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DNA damage evaluated by gammaH2AX foci formation by a selective group of chemical/physical stressors

21 January 2018

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21 January 2018

Identifiers

DOI

10.1093/TOXSCI/KFU066

1 reference

5 November 2017

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