(Q42716227)

English

MT1-selective melatonin receptor ligands: synthesis, pharmacological evaluation, and molecular dynamics investigation of N-{[(3-O-substituted)anilino]alkyl}amides.

scientific article

In more languages

Statements

scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22927210%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

MT1-selective melatonin receptor ligands: synthesis, pharmacological evaluation, and molecular dynamics investigation of N-{[(3-O-substituted)anilino]alkyl}amides (English)

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22927210%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

0 references

1 reference

based on heuristic

inferred from title

2

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22927210%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

1

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22927210%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

3

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22927210%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

4

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22927210%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

Annalida Bedini

8

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22927210%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

Simone Lucarini

9

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22927210%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

Gilberto Spadoni

11

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22927210%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

10

object named as

Giorgio Tarzia

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22927210%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

5

object named as

Valeria Lucini

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22927210%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

Francesco Scaglione

7

object named as

Francesco Scaglione

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22927210%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

Silvana Dugnani

6

object named as

Silvana Dugnani

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22927210%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

publication date

27 August 2012

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22927210%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22927210%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

7

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22927210%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

11

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22927210%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

1954-1964

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22927210%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

Physiological and metabolic functions of melatonin

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200303

21 January 2018

Physiological effects of melatonin: role of melatonin receptors and signal transduction pathways

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200303

21 January 2018

Melatonin: Characteristics, Concerns, and Prospects

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200303

21 January 2018

Melatonin in mood disorders

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200303

21 January 2018

Melatonin as a potential therapeutic agent in psychiatric illness.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200303

21 January 2018

The immunotherapeutic potential of melatonin

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200303

21 January 2018

Potential roles of melatonin and chronotherapy among the new trends in hypertension treatment

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200303

21 January 2018

Melatonin: a hormone that modulates pain

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200303

21 January 2018

Anti-inflammatory actions of melatonin and its metabolites, N1-acetyl-N2-formyl-5-methoxykynuramine (AFMK) and N1-acetyl-5-methoxykynuramine (AMK), in macrophages

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200303

21 January 2018

Antioxidative Protection by Melatonin: Multiplicity of Mechanisms from Radical Detoxification to Radical Avoidance

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200303

21 January 2018

Neuroprotection by radical avoidance: search for suitable agents.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200303

21 January 2018

Melatonin as a chronobiotic/anticancer agent: cellular, biochemical, and molecular mechanisms of action and their implications for circadian-based cancer therapy

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200303

21 January 2018

Melatonin in the treatment of cancer: a systematic review of randomized controlled trials and meta-analysis

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200303

21 January 2018

A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200303

21 January 2018

Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200303

21 January 2018

Efficacy of prolonged release melatonin in insomnia patients aged 55–80 years: quality of sleep and next-day alertness outcomes

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200303

21 January 2018

Pharmacology of ramelteon, a selective MT1/MT2 receptor agonist: a novel therapeutic drug for sleep disorders

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200303

21 January 2018

Melatonin and its analogs in insomnia and depression

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200303

21 January 2018

Melatonin receptor agonists: new options for insomnia and depression treatment

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200303

21 January 2018

International Union of Basic and Clinical Pharmacology. LXXV. Nomenclature, classification, and pharmacology of G protein-coupled melatonin receptors

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200303

21 January 2018

Melatonin receptors, heterodimerization, signal transduction and binding sites: what's new?

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200303

21 January 2018

Melatonin receptors step into the light: cloning and classification of subtypes

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200303

21 January 2018

Identification of the melatonin-binding site MT3 as the quinone reductase 2.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200303

21 January 2018

Melatonin receptors in humans: biological role and clinical relevance

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200303

21 January 2018

Functional MT1 and MT2 melatonin receptors in mammals

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200303

21 January 2018

Targeted disruption of the mouse Mel(1b) melatonin receptor

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200303

21 January 2018

Rhythmic gene expression in pituitary depends on heterologous sensitization by the neurohormone melatonin

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200303

21 January 2018

Melatonin modulates visual function and cell viability in the mouse retina via the MT1 melatonin receptor.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200303

21 January 2018

Constitutively active melatonin MT(1) receptors in male rat caudal arteries

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200303

21 January 2018

MT(2) melatonin receptors are present and functional in rat caudal artery

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200303

21 January 2018

Melatonin receptor subtype MT2 (Mel 1b) and not mt1 (Mel 1a) is associated with melatonin-induced enhancement of cell-mediated and humoral immunity

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200303

21 January 2018

Melatonin receptor antagonists that differentiate between the human Mel1a and Mel1b recombinant subtypes are used to assess the pharmacological profile of the rabbit retina ML1 presynaptic heteroreceptor

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200303

21 January 2018

Promotion of non-rapid eye movement sleep and activation of reticular thalamic neurons by a novel MT2 melatonin receptor ligand

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200303

21 January 2018

Recent advances in melatonin receptor ligands.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200303

21 January 2018

Recent advances in the development of melatonin MT(1) and MT(2) receptor agonists.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200303

21 January 2018

Recent progress in the development of agonists and antagonists for melatonin receptors

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200303

21 January 2018

Design and synthesis of naphthalenic dimers as selective MT1 melatoninergic ligands

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200303

21 January 2018

Design, synthesis and pharmacological evaluation of novel naphthalenic derivatives as selective MT(1) melatoninergic ligands

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200303

21 January 2018

Synthesis and biological activity of new melatonin dimeric derivatives

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200303

21 January 2018

Preparation of 4-azaindole and 7-azaindole dimers with a bisalkoxyalkyl spacer in order to preferentially target melatonin MT1 receptors over melatonin MT2 receptors

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200303

21 January 2018

Bivalent ligand approach on N-{2-[(3-methoxyphenyl)methylamino]ethyl}acetamide: synthesis, binding affinity and intrinsic activity for MT(1) and MT(2) melatonin receptors

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200303

21 January 2018

Synthesis and structure-activity relationship of novel benzoxazole derivatives as melatonin receptor agonists

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200303

21 January 2018

Design and synthesis of benzoxazole derivatives as novel melatoninergic ligands

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200303

21 January 2018

N-[2-[2-(4-Phenylbutyl)benzofuran-4-yl]cyclopropylmethyl]acetamide: an orally bioavailable melatonin receptor agonist

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200303

21 January 2018

New selective ligands of human cloned melatonin MT1 and MT2 receptors.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200303

21 January 2018

N-Acetyl-5-arylalkoxytryptamine analogs: probing the melatonin receptors for MT(1) -selectivity.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200303

21 January 2018

Multivalent-based drug design applied to serotonin 5-HT(4) receptor oligomers

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200303

21 January 2018

N-(substituted-anilinoethyl)amides: design, synthesis, and pharmacological characterization of a new class of melatonin receptor ligands

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200303

21 January 2018

N-(Anilinoethyl)amides: design and synthesis of metabolically stable, selective melatonin receptor ligands

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200303

21 January 2018

Analysis of structure-activity relationships for MT2 selective antagonists by melatonin MT1 and MT2 receptor models

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200303

21 January 2018

Melatonin receptor pharmacology: toward subtype specificity

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200303

21 January 2018

A new melatonin receptor ligand with mt1-agonist and MT2-antagonist properties.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200303

21 January 2018

Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200303

21 January 2018

Crystal structure of the β2 adrenergic receptor-Gs protein complex

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200303

21 January 2018

Reassessing the melatonin pharmacophore--enantiomeric resolution, pharmacological activity, structure analysis, and molecular modeling of a constrained chiral melatonin analogue

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200303

21 January 2018

Mutagenesis studies of the human MT2 melatonin receptor

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200303

21 January 2018

Molecular modeling of human MT2 melatonin receptor: the role of Val204, Leu272 and Tyr298 in ligand binding.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200303

21 January 2018

The 2.6 angstrom crystal structure of a human A2A adenosine receptor bound to an antagonist

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200303

21 January 2018

Ligand binding and subtype selectivity of the human A(2A) adenosine receptor: identification and characterization of essential amino acid residues.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200303

21 January 2018

Systematic analysis of the entire second extracellular loop of the V(1a) vasopressin receptor: key residues, conserved throughout a G-protein-coupled receptor family, identified.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200303

21 January 2018

Melatonin receptor agonists: SAR and applications to the treatment of sleep-wake disorders

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200303

21 January 2018

Pharmacological characterization of the human melatonin Mel1a receptor following stable transfection into NIH3T3 cells

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200303

21 January 2018

Ligand efficacy and potency at recombinant human MT2 melatonin receptors: evidence for agonist activity of some mt1-antagonists

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200303

21 January 2018

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200303

21 January 2018

2-[N-Acylamino(C1-C3)alkyl]indoles as MT1 melatonin receptor partial agonists, antagonists, and putative inverse agonists.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200303

21 January 2018

Structural insights into agonist-induced activation of G-protein-coupled receptors

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200303

21 January 2018

Reorganizing the protein space at the Universal Protein Resource (UniProt)

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200303

21 January 2018

CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200303

21 January 2018

Comparative protein modelling by satisfaction of spatial restraints

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200303

21 January 2018

PROCHECK: a program to check the stereochemical quality of protein structures

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200303

21 January 2018

OPM: orientations of proteins in membranes database

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200303

21 January 2018

Comparison of multiple Amber force fields and development of improved protein backbone parameters

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200303

21 January 2018

Development and testing of a general amber force field

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200303

21 January 2018

Automatic atom type and bond type perception in molecular mechanical calculations

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200303

21 January 2018

A common, avoidable source of error in molecular dynamics integrators.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200303

21 January 2018

Reversible multiple time scale molecular dynamics

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200303

21 January 2018

Selective MT2 melatonin receptor antagonists block melatonin-mediated phase advances of circadian rhythms

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200303

7 January 2021

based on heuristic

inferred from DOI database lookup

2-Substituted 5-methoxy-N-acyltryptamines: synthesis, binding affinity for the melatonin receptor, and evaluation of the biological activity

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200303

7 January 2021

based on heuristic

inferred from DOI database lookup

The roles of valine 208 and histidine 211 in ligand binding and receptor function of the ovine Mel1a beta melatonin receptor

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200303

7 January 2021

based on heuristic

inferred from DOI database lookup

Mutagenesis of human Mel1a melatonin receptor expressed in yeast reveals domains important for receptor function

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200303

7 January 2021

based on heuristic

inferred from DOI database lookup

Amino acids of the alpha1B-adrenergic receptor involved in agonist binding: differences in docking catecholamines to receptor subtypes

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200303

7 January 2021

based on heuristic

inferred from DOI database lookup

Development and Testing of the OPLS All-Atom Force Field on Conformational Energetics and Properties of Organic Liquids

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200303

7 January 2021

based on heuristic

inferred from DOI database lookup

A smooth particle mesh Ewald method

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200303

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1002/CMDC.201200303

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22927210%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22927210%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q42716227&oldid=1755153806"