(Q42716638)

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Evaluation of dopamine D₂/D₃ and serotonin 5-HT₂A receptor occupancy for a novel antipsychotic, lurasidone, in conscious common marmosets using small-animal positron emission tomography

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scholarly article

1 reference

Europe PubMed Central

5 November 2017

Evaluation of dopamine D₂/D₃ and serotonin 5-HT₂A receptor occupancy for a novel antipsychotic, lurasidone, in conscious common marmosets using small-animal positron emission tomography (English)

1 reference

Europe PubMed Central

5 November 2017

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1 reference

ChEBI release 2020-05-28

author name string

Shunsuke Nakazawa

1

1 reference

Europe PubMed Central

5 November 2017

Chihiro Yokoyama

2

1 reference

Europe PubMed Central

5 November 2017

Naohiro Nishimura

3

1 reference

Europe PubMed Central

5 November 2017

Tomoko Horisawa

4

1 reference

Europe PubMed Central

5 November 2017

Akihiro Kawasaki

5

1 reference

Europe PubMed Central

5 November 2017

Hiroshi Mizuma

6

1 reference

Europe PubMed Central

5 November 2017

Hisashi Doi

7

1 reference

Europe PubMed Central

5 November 2017

Hirotaka Onoe

8

1 reference

Europe PubMed Central

5 November 2017

publication date

7 August 2012

1 reference

Europe PubMed Central

5 November 2017

Psychopharmacology

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Europe PubMed Central

5 November 2017

225

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Europe PubMed Central

5 November 2017

2

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Europe PubMed Central

5 November 2017

329-339

1 reference

Europe PubMed Central

5 November 2017

https://scigraph.springernature.com/pub.10.1007/s00213-012-2815-9

0 references

Amisulpride is a potent 5-HT7 antagonist: relevance for antidepressant actions in vivo

1 reference

https://api.crossref.org/works/10.1007%2FS00213-012-2815-9

21 January 2018

Occupancy of agonist drugs at the 5-HT1A receptor

1 reference

https://api.crossref.org/works/10.1007%2FS00213-012-2815-9

21 January 2018

Dopamine release induced by atypical antipsychotics in prefrontal cortex requires 5-HT(1A) receptors but not 5-HT(2A) receptors

1 reference

https://api.crossref.org/works/10.1007%2FS00213-012-2815-9

21 January 2018

Molecular imaging of small animals with dedicated PET tomographs

1 reference

https://api.crossref.org/works/10.1007%2FS00213-012-2815-9

21 January 2018

Lurasidone for schizophrenia: a brief review of a new second-generation antipsychotic

1 reference

https://api.crossref.org/works/10.1007%2FS00213-012-2815-9

21 January 2018

Stereoselective binding of 11C-raclopride in living human brain--a search for extrastriatal central D2-dopamine receptors by PET.

1 reference

https://api.crossref.org/works/10.1007%2FS00213-012-2815-9

21 January 2018

Identification of a serotonin/glutamate receptor complex implicated in psychosis

1 reference

https://api.crossref.org/works/10.1007%2FS00213-012-2815-9

21 January 2018

Mechanism of new antipsychotic medications: occupancy is not just antagonism

1 reference

https://api.crossref.org/works/10.1007%2FS00213-012-2815-9

21 January 2018

Synthesis and in vitro affinities of various MDL 100907 derivatives as potential 18F-radioligands for 5-HT2A receptor imaging with PET.

1 reference

https://api.crossref.org/works/10.1007%2FS00213-012-2815-9

21 January 2018

Anesthesia and other considerations for in vivo imaging of small animals

1 reference

https://api.crossref.org/works/10.1007%2FS00213-012-2815-9

21 January 2018

The role of 5-hydroxytryptamine 7 receptors in the phencyclidine-induced novel object recognition deficit in rats.

1 reference

https://api.crossref.org/works/10.1007%2FS00213-012-2815-9

21 January 2018

The effects of selective antagonists of serotonin 5-HT7 and 5-HT1A receptors on MK-801-induced impairment of learning and memory in the passive avoidance and Morris water maze tests in rats: mechanistic implications for the beneficial effects of the

1 reference

https://api.crossref.org/works/10.1007%2FS00213-012-2815-9

21 January 2018

Olanzapine differentially affects 5-HT2Aand2C receptor mRNA expression in the rat brain.

1 reference

https://api.crossref.org/works/10.1007%2FS00213-012-2815-9

21 January 2018

Pharmacological constraints associated with positron emission tomographic scanning of small laboratory animals.

1 reference

https://api.crossref.org/works/10.1007%2FS00213-012-2815-9

21 January 2018

5-HT(2A) and D(2) receptor blockade increases cortical DA release via 5-HT(1A) receptor activation: a possible mechanism of atypical antipsychotic-induced cortical dopamine release

1 reference

https://api.crossref.org/works/10.1007%2FS00213-012-2815-9

21 January 2018

Consensus nomenclature for in vivo imaging of reversibly binding radioligands

1 reference

https://api.crossref.org/works/10.1007%2FS00213-012-2815-9

21 January 2018

Pharmacological profile of lurasidone, a novel antipsychotic agent with potent 5-hydroxytryptamine 7 (5-HT7) and 5-HT1A receptor activity

1 reference

https://api.crossref.org/works/10.1007%2FS00213-012-2815-9

21 January 2018

Experiment assessment of mass effects in the rat: implications for small animal PET imaging.

1 reference

https://api.crossref.org/works/10.1007%2FS00213-012-2815-9

21 January 2018

Does fast dissociation from the dopamine d(2) receptor explain the action of atypical antipsychotics?: A new hypothesis

1 reference

https://api.crossref.org/works/10.1007%2FS00213-012-2815-9

21 January 2018

Relationship between dopamine D(2) occupancy, clinical response, and side effects: a double-blind PET study of first-episode schizophrenia

1 reference

https://api.crossref.org/works/10.1007%2FS00213-012-2815-9

21 January 2018

Validation of a rat in vivo [(3)H]M100907 binding assay to determine a translatable measure of 5-HT(2A) receptor occupancy

1 reference

https://api.crossref.org/works/10.1007%2FS00213-012-2815-9

21 January 2018

Mass effect of injected dose in small rodent imaging by SPECT and PET.

1 reference

https://api.crossref.org/works/10.1007%2FS00213-012-2815-9

21 January 2018

Simplified reference tissue model for PET receptor studies.

1 reference

https://api.crossref.org/works/10.1007%2FS00213-012-2815-9

21 January 2018

Small-animal positron emission tomography as a tool for neuropharmacology

1 reference

https://api.crossref.org/works/10.1007%2FS00213-012-2815-9

21 January 2018

Serotonergic basis of antipsychotic drug effects in schizophrenia.

1 reference

https://api.crossref.org/works/10.1007%2FS00213-012-2815-9

21 January 2018

[11C]MDL 100907, a radioligland for selective imaging of 5-HT(2A) receptors with positron emission tomography

1 reference

https://api.crossref.org/works/10.1007%2FS00213-012-2815-9

21 January 2018

A PET study of dopamine D2 and serotonin 5-HT2 receptor occupancy in patients with schizophrenia treated with therapeutic doses of ziprasidone

1 reference

https://api.crossref.org/works/10.1007%2FS00213-012-2815-9

21 January 2018

Differential effects of aripiprazole on D(2), 5-HT(2), and 5-HT(1A) receptor occupancy in patients with schizophrenia: a triple tracer PET study.

1 reference

https://api.crossref.org/works/10.1007%2FS00213-012-2815-9

21 January 2018

The effects of clozapine, risperidone, and olanzapine on cognitive function in schizophrenia

1 reference

https://api.crossref.org/works/10.1007%2FS00213-012-2815-9

21 January 2018

Lurasidone: a new drug in development for schizophrenia

1 reference

https://api.crossref.org/works/10.1007%2FS00213-012-2815-9

21 January 2018

In vivo serotonin-sensitive binding of [11C]CUMI-101: a serotonin 1A receptor agonist positron emission tomography radiotracer

1 reference

https://api.crossref.org/works/10.1007%2FS00213-012-2815-9

21 January 2018

Lurasidone in the treatment of acute schizophrenia: a double-blind, placebo-controlled trial

1 reference

https://api.crossref.org/works/10.1007%2FS00213-012-2815-9

21 January 2018

Dissociation between in vivo occupancy and functional antagonism of dopamine D2 receptors: comparing aripiprazole to other antipsychotics in animal models

1 reference

https://api.crossref.org/works/10.1007%2FS00213-012-2815-9

21 January 2018

Comparative pharmacology of antipsychotics possessing combined dopamine D2 and serotonin 5-HT1A receptor properties.

1 reference

https://api.crossref.org/works/10.1007%2FS00213-012-2815-9

21 January 2018

Ketamine increases the striatal N-[11C]methylspiperone binding in vivo: positron emission tomography study using conscious rhesus monkey.

1 reference

https://api.crossref.org/works/10.1007%2FS00213-012-2815-9

21 January 2018

In vivo PET study of 5HT(2A) serotonin and D(2) dopamine dysfunction in drug-naive obsessive-compulsive disorder.

1 reference

https://api.crossref.org/works/10.1007%2FS00213-012-2815-9

21 January 2018

Amisulpride improves depressive symptoms in acute exacerbations of schizophrenia: comparison with haloperidol and risperidone

1 reference

https://api.crossref.org/works/10.1007%2FS00213-012-2815-9

21 January 2018

Limbic selectivity of clozapine.

1 reference

https://api.crossref.org/works/10.1007%2FS00213-012-2815-9

21 January 2018

Utility of small-animal positron emission tomographic imaging of rats for preclinical development of drugs acting on the serotonin transporter

1 reference

https://api.crossref.org/works/10.1007%2FS00213-012-2815-9

21 January 2018

Haloperidol-induced catalepsy is mediated by postsynaptic dopamine receptors

1 reference

https://api.crossref.org/works/10.1007%2FS00213-012-2815-9

21 January 2018

Ziprasidone: a novel antipsychotic agent with a unique human receptor binding profile

1 reference

https://api.crossref.org/works/10.1007%2FS00213-012-2815-9

21 January 2018

Investigation of the CNS penetration of a potent 5-HT2a receptor antagonist (MDL 100,907) and an active metabolite (MDL 105,725) using in vivo microdialysis sampling in the rat.

1 reference

https://api.crossref.org/works/10.1007%2FS00213-012-2815-9

21 January 2018

Antipsychotic drug doses and neuroleptic/dopamine receptors

1 reference

https://api.crossref.org/works/10.1007%2FS00213-012-2815-9

21 January 2018

Occupancy of dopamine D₂ and D₃ and serotonin 5-HT₁A receptors by the novel antipsychotic drug candidate, cariprazine (RGH-188), in monkey brain measured using positron emission tomography

1 reference

https://api.crossref.org/works/10.1007%2FS00213-012-2815-9

21 January 2018

Binding of antipsychotic drugs to cortical 5-HT2A receptors: a PET study of chlorpromazine, clozapine, and amisulpride in schizophrenic patients.

1 reference

https://api.crossref.org/works/10.1007%2FS00213-012-2815-9

21 January 2018

Dose-dependent binding of AZD3783 to brain 5-HT1B receptors in non-human primates and human subjects: a positron emission tomography study with [11C]AZ10419369.

1 reference

https://api.crossref.org/works/10.1007%2FS00213-012-2815-9

21 January 2018

Noise reduction in the simplified reference tissue model for neuroreceptor functional imaging.

1 reference

https://api.crossref.org/works/10.1007%2FS00213-012-2815-9

21 January 2018

Antagonist functional selectivity: 5-HT2A serotonin receptor antagonists differentially regulate 5-HT2A receptor protein level in vivo

1 reference

https://api.crossref.org/works/10.1007%2FS00213-012-2815-9

21 January 2018

Mapping of serotonin transporters by positron emission tomography with [11C]DASB in conscious common marmosets: comparison with rhesus monkeys

1 reference

https://api.crossref.org/works/10.1007%2FS00213-012-2815-9

21 January 2018

Effect of L-dopa and 6-hydroxydopamine lesioning on [11C]raclopride binding in rat striatum, quantified using PET

1 reference

https://api.crossref.org/works/10.1007%2FS00213-012-2815-9

21 January 2018

D1, D2, and 5-HT2 receptor occupancy in relation to clozapine serum concentration: a PET study of schizophrenic patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/22868411

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The ratios of serotonin2 and dopamine2 affinities differentiate atypical and typical antipsychotic drugs

1 reference

https://pubmed.ncbi.nlm.nih.gov/22868411

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Age-related reduction of [11C]MDL100,907 binding to central 5-HT(2A) receptors: PET study in the conscious monkey brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/22868411

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ketamine decreased striatal [(11)C]raclopride binding with no alterations in static dopamine concentrations in the striatal extracellular fluid in the monkey brain: multiparametric PET studies combined with microdialysis analysis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22868411

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fluorine-18-altanserin: a radioligand for the study of serotonin receptors with PET: radiolabeling and in vivo biologic behavior in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/22868411

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical and theoretical implications of 5-HT2 and D2 receptor occupancy of clozapine, risperidone, and olanzapine in schizophrenia

1 reference

https://pubmed.ncbi.nlm.nih.gov/22868411

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PET imaging of central 5-HT2A receptors with carbon-11-MDL 100,907.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22868411

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Preclinical characterization of the potential of the putative atypical antipsychotic MDL 100,907 as a potent 5-HT2A antagonist with a favorable CNS safety profile

1 reference

https://pubmed.ncbi.nlm.nih.gov/22868411

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Serotonin 5-HT2 receptors in schizophrenic patients studied by positron emission tomography

1 reference

https://pubmed.ncbi.nlm.nih.gov/22868411

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lurasidone in the treatment of schizophrenia: a randomized, double-blind, placebo- and olanzapine-controlled study

1 reference

https://pubmed.ncbi.nlm.nih.gov/22868411

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.1007/S00213-012-2815-9

1 reference

Europe PubMed Central

5 November 2017

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1 reference

Europe PubMed Central

5 November 2017

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