(Q42729095)

English

Combining the FLT3 inhibitor PKC412 and the triterpenoid CDDO-Me synergistically induces apoptosis in acute myeloid leukemia with the internal tandem duplication mutation

scientific article published on 22 June 2010

In more languages

Statements

scholarly article

1 reference

Europe PubMed Central

5 November 2017

Combining the FLT3 inhibitor PKC412 and the triterpenoid CDDO-Me synergistically induces apoptosis in acute myeloid leukemia with the internal tandem duplication mutation (English)

1 reference

Europe PubMed Central

5 November 2017

acute myeloid leukemia

1 reference

based on heuristic

inferred from title

author name string

Rehan Ahmad

1

1 reference

Europe PubMed Central

5 November 2017

Suiyang Liu

2

1 reference

Europe PubMed Central

5 November 2017

Ellen Weisberg

3

1 reference

Europe PubMed Central

5 November 2017

Erik Nelson

4

1 reference

Europe PubMed Central

5 November 2017

Ilene Galinsky

5

1 reference

Europe PubMed Central

5 November 2017

Colin Meyer

6

1 reference

Europe PubMed Central

5 November 2017

Donald Kufe

7

1 reference

Europe PubMed Central

5 November 2017

Surender Kharbanda

8

1 reference

Europe PubMed Central

5 November 2017

Richard Stone

9

1 reference

Europe PubMed Central

5 November 2017

publication date

22 June 2010

1 reference

Europe PubMed Central

5 November 2017

Molecular Cancer Research

1 reference

Europe PubMed Central

5 November 2017

8

1 reference

Europe PubMed Central

5 November 2017

7

1 reference

Europe PubMed Central

5 November 2017

986-993

1 reference

Europe PubMed Central

5 November 2017

Oleanane triterpenoid CDDO-Me inhibits growth and induces apoptosis in prostate cancer cells through a ROS-dependent mechanism

1 reference

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Molecular genetic pathways as therapeutic targets in acute myeloid leukemia

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Potential role of sorafenib in the treatment of acute myeloid leukemia

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New regulators of NF-kappaB in inflammation

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Canonical and non-canonical JAK-STAT signaling

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Targeting FLT3 for the treatment of leukemia

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Deregulation of signaling pathways in acute myeloid leukemia

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Triterpenoid CDDO-methyl ester inhibits the Janus-activated kinase-1 (JAK1)-->signal transducer and activator of transcription-3 (STAT3) pathway by direct inhibition of JAK1 and STAT3

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Mutant FLT3: a direct target of sorafenib in acute myelogenous leukemia

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Epigenetic regulation of signal transducer and activator of transcription 3 in acute myeloid leukemia

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FLT3 D835/I836 mutations are associated with poor disease-free survival and a distinct gene-expression signature among younger adults with de novo cytogenetically normal acute myeloid leukemia lacking FLT3 internal tandem duplications

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Targeting the cytoplasmic and nuclear functions of signal transducers and activators of transcription 3 for cancer therapy

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Rationale for a phase I trial of erlotinib and the mammalian target of rapamycin inhibitor everolimus (RAD001) for patients with relapsed non small cell lung cancer

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Triterpenoids and rexinoids as multifunctional agents for the prevention and treatment of cancer.

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Antigen-receptor signaling to nuclear factor kappa B.

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Prolonged exposure to FLT3 inhibitors leads to resistance via activation of parallel signaling pathways

1 reference

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Triterpenoid CDDO-Me blocks the NF-kappaB pathway by direct inhibition of IKKbeta on Cys-179.

1 reference

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Phase 1 clinical results with tandutinib (MLN518), a novel FLT3 antagonist, in patients with acute myelogenous leukemia or high-risk myelodysplastic syndrome: safety, pharmacokinetics, and pharmacodynamics

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Simultaneous inhibition of PDK1/AKT and Fms-like tyrosine kinase 3 signaling by a small-molecule KP372-1 induces mitochondrial dysfunction and apoptosis in acute myelogenous leukemia

1 reference

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A novel mechanism of action of methyl-2-cyano-3,12 dioxoolean-1,9 diene-28-oate: direct permeabilization of the inner mitochondrial membrane to inhibit electron transport and induce apoptosis

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The role of IL-6 and STAT3 in inflammation and cancer

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Identification of a genetic signature of activated signal transducer and activator of transcription 3 in human tumors

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Triterpenoid CDDO-Im downregulates PML/RARalpha expression in acute promyelocytic leukemia cells.

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Combination of rapamycin and protein tyrosine kinase (PTK) inhibitors for the treatment of leukemias caused by oncogenic PTKs

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Single-agent CEP-701, a novel FLT3 inhibitor, shows biologic and clinical activity in patients with relapsed or refractory acute myeloid leukemia

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The role of FLT3 in haematopoietic malignancies

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Flt3 mutations and leukaemia

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A road map for those who don't know JAK-STAT

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The novel triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid (CDDO) potently enhances apoptosis induced by tumor necrosis factor in human leukemia cells

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Absence of the wild-type allele predicts poor prognosis in adult de novo acute myeloid leukemia with normal cytogenetics and the internal tandem duplication of FLT3: a cancer and leukemia group B study.

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STATs in oncogenesis

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Patients with acute myeloid leukemia and an activating mutation in FLT3 respond to a small-molecule FLT3 tyrosine kinase inhibitor, PKC412.

1 reference

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Novel triterpenoid CDDO-Me is a potent inducer of apoptosis and differentiation in acute myelogenous leukemia

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1 reference

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1 reference

https://pubmed.ncbi.nlm.nih.gov/20571062

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based on heuristic

inferred from PubMed ID database lookup

Internal tandem duplication of the flt3 gene found in acute myeloid leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/20571062

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The novel triterpenoid 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid induces apoptosis of human myeloid leukemia cells by a caspase-8-dependent mechanism

1 reference

https://pubmed.ncbi.nlm.nih.gov/20571062

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acute myeloid leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/20571062

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1158/1541-7786.MCR-10-0154

1 reference

Europe PubMed Central

5 November 2017

1 reference

Europe PubMed Central

5 November 2017

1 reference

Europe PubMed Central

5 November 2017

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