(Q42736886)

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TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy

scientific article published on May 2016

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scholarly article

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Europe PubMed Central

6 November 2017

TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy. (English)

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6 November 2017

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6 June 2020

Christopher Keene

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6 June 2020

Jaime Grutzendler

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Jaime Grutzendler

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6 June 2020

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Peng Yuan

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6 June 2020

Carlo Condello

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6 June 2020

Yaming Wang

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6 June 2020

Thomas D Bird

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6 June 2020

Steven M Paul

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6 June 2020

Wenjie Luo

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6 June 2020

David Baddeley

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6 June 2020

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1 May 2016

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6 November 2017

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6 June 2020

90

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6 June 2020

4

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6 June 2020

724-739

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6 June 2020

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11 June 2022

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Attenuation of β-Amyloid Deposition and Neurotoxicity by Chemogenetic Modulation of Neural Activity

1 reference

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Pharmacological targeting of CSF1R inhibits microglial proliferation and prevents the progression of Alzheimer's-like pathology

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CD33 modulates TREM2: convergence of Alzheimer loci.

1 reference

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27 May 2018

Apolipoprotein E Is a Ligand for Triggering Receptor Expressed on Myeloid Cells 2 (TREM2).

1 reference

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Colony-stimulating factor 1 receptor inhibition prevents microglial plaque association and improves cognition in 3xTg-AD mice

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Massive accumulation of luminal protease-deficient axonal lysosomes at Alzheimer's disease amyloid plaques

1 reference

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R47H Variant of TREM2 Associated With Alzheimer Disease in a Large Late-Onset Family: Clinical, Genetic, and Neuropathological Study

1 reference

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27 May 2018

Fibrillar amyloid plaque formation precedes microglial activation

1 reference

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27 May 2018

TREM2 deficiency eliminates TREM2+ inflammatory macrophages and ameliorates pathology in Alzheimer's disease mouse models.

1 reference

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27 May 2018

TREM2 lipid sensing sustains the microglial response in an Alzheimer's disease model

1 reference

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27 May 2018

Microglia constitute a barrier that prevents neurotoxic protofibrillar Aβ42 hotspots around plaques

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A genome-wide gene-expression analysis and database in transgenic mice during development of amyloid or tau pathology

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Inconsistencies and controversies surrounding the amyloid hypothesis of Alzheimer's disease

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27 May 2018

TREM2 Protein Expression Changes Correlate with Alzheimer's Disease Neurodegenerative Pathologies in Post-Mortem Temporal Cortices

1 reference

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27 May 2018

TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis

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27 May 2018

Coding variants in TREM2 increase risk for Alzheimer's disease

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27 May 2018

Altered microglial response to Aβ plaques in APPPS1-21 mice heterozygous for TREM2.

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27 May 2018

In vivo imaging reveals sigmoidal growth kinetic of β-amyloid plaques.

1 reference

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27 May 2018

Amyloid-β positron emission tomography imaging probes: a critical review

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27 May 2018

TREM2 Variants in Alzheimer's Disease

1 reference

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27 May 2018

Variant of TREM2 Associated with the Risk of Alzheimer's Disease

1 reference

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Amyloid plaque formation precedes dendritic spine loss

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27 May 2018

Multicolor time-stamp reveals the dynamics and toxicity of amyloid deposition

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TLR4 mutation reduces microglial activation, increases Aβ deposits and exacerbates cognitive deficits in a mouse model of Alzheimer's disease

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CX3CR1 in microglia regulates brain amyloid deposition through selective protofibrillar amyloid-β phagocytosis

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Postmortem interval effect on RNA and gene expression in human brain tissue

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The role of microglia in amyloid clearance from the AD brain

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TREM2- and DAP12-dependent activation of PI3K requires DAP10 and is inhibited by SHIP1.

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CD14 and toll-like receptors 2 and 4 are required for fibrillar A{beta}-stimulated microglial activation.

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The role of apolipoprotein E in Alzheimer's disease

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TREM2 is upregulated in amyloid plaque-associated microglia in aged APP23 transgenic mice

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Microglia: active sensor and versatile effector cells in the normal and pathologic brain

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Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation.

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1 reference

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12 December 2020

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3D-Reconstruction of microglia and amyloid in APP23 transgenic mice: no evidence of intracellular amyloid

1 reference

https://pubmed.ncbi.nlm.nih.gov/27196974

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/J.NEURON.2016.05.003

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Europe PubMed Central

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6 June 2020

1 reference

Europe PubMed Central

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6 June 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27196974%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

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