(Q42795770)

7 November 2017

title

Identification and characterization of mutations in Ha-Ras that selectively decrease binding to cRaf-1. (English)

1 reference

7 November 2017

Winkler DG

1

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7 November 2017

Johnson JC

series ordinal

2

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7 November 2017

Cooper JA

series ordinal

3

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7 November 2017

Vojtek AB

series ordinal

4

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7 November 2017

language of work or name

English

0 references

publication date

1 September 1997

1 reference

Journal of Biological Chemistry

7 November 2017

number of pages

8

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based on heuristic

inferred from page(s)

published in

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7 November 2017

volume

272

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7 November 2017

issue

39

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7 November 2017

page(s)

24402-24409

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The effector interactions of p21ras

7 November 2017

cites work

1 reference

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Identification of small clusters of divergent amino acids that mediate the opposing effects of ras and Krev-1.

21 January 2018

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21 January 2018

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Identification of the guanine nucleotide dissociation stimulator for Ral as a putative effector molecule of R-ras, H-ras, K-ras, and Rap

21 January 2018

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Activated Ras interacts with the Ral guanine nucleotide dissociation stimulator

21 January 2018

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ralGDS family members interact with the effector loop of ras p21.

21 January 2018

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A human protein selected for interference with Ras function interacts directly with Ras and competes with Raf1

21 January 2018

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Identification of AF-6 and canoe as putative targets for Ras.

21 January 2018

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Increased expression of the Ras suppressor Rsu-1 enhances Erk-2 activation and inhibits Jun kinase activation

21 January 2018

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Phosphatidylinositol-3-OH kinase as a direct target of Ras

21 January 2018

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The activation of phosphatidylinositol 3-kinase by Ras

21 January 2018

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Mammalian Ras interacts directly with the serine/threonine kinase Raf

21 January 2018

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Genetic definition of ras effector elements

21 January 2018

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Effector domain mutations dissociate p21ras effector function and GTPase-activating protein interaction

21 January 2018

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Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase

21 January 2018

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Expression of achaete-scute homolog 3 in Xenopus embryos converts ectodermal cells to a neural fate

21 January 2018

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Expression of human class II major histocompatibility complex antigens using retrovirus vectors

21 January 2018

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Oncogenic Ras activation of Raf/mitogen-activated protein kinase-independent pathways is sufficient to cause tumorigenic transformation

21 January 2018

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Biological assays for Ras transformation

21 January 2018

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Production of high-titer helper-free retroviruses by transient transfection

21 January 2018

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Differential complementation of Bcr-Abl point mutants with c-Myc

21 January 2018

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Tyrosine phosphorylation and activation of homologous protein kinases during oocyte maturation and mitogenic activation of fibroblasts

21 January 2018

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Isolation of monoclonal antibodies specific for human c-myc proto-oncogene product

21 January 2018

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p110delta, a novel phosphatidylinositol 3-kinase catalytic subunit that associates with p85 and is expressed predominantly in leukocytes

21 January 2018

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Mutational analysis of a ras catalytic domain

21 January 2018

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Differential regulation of Raf-1, A-Raf, and B-Raf by oncogenic ras and tyrosine kinases

21 January 2018

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Biochemical Analysis of MEK Activation in NIH3T3 Fibroblasts

21 January 2018

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Phosphotyrosine-containing proteins are concentrated in focal adhesions and intercellular junctions in normal cells

21 January 2018

1 reference

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Differential interaction of the ras family GTP-binding proteins H-Ras, Rap1A, and R-Ras with the putative effector molecules Raf kinase and Ral-guanine nucleotide exchange factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.39.24402

Identification of amino acid residues required for Ras p21 target activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.39.24402

Critical binding and regulatory interactions between Ras and Raf occur through a small, stable N-terminal domain of Raf and specific Ras effector residues

21 January 2018

1 reference

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Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1

21 January 2018

1 reference

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Differential structural requirements for interaction of Ras protein with its distinct downstream effectors.

21 January 2018

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Ras/Rap effector specificity determined by charge reversal

21 January 2018

1 reference

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The 2.2 A crystal structure of the Ras-binding domain of the serine/threonine kinase c-Raf1 in complex with Rap1A and a GTP analogue

21 January 2018

1 reference

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A ras effector domain mutant which is temperature sensitive for cellular transformation: interactions with GTPase-activating protein and NF-1

21 January 2018

1 reference

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Molecular switch for signal transduction: structural differences between active and inactive forms of protooncogenic ras proteins

21 January 2018

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Ras-dependent induction of cellular responses by constitutively active phosphatidylinositol-3 kinase

21 January 2018

1 reference

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Ras interaction with two distinct binding domains in Raf-1 may be required for Ras transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.39.24402

An intact Raf zinc finger is required for optimal binding to processed Ras and for ras-dependent Raf activation in situ

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.39.24402

Multiple Ras functions can contribute to mammalian cell transformation

21 January 2018

1 reference

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Stimulation of membrane ruffling and MAP kinase activation by distinct effectors of RAS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.39.24402

A single amino acid change in Raf-1 inhibits Ras binding and alters Raf-1 function

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.39.24402

The cytoplasmic protein GAP is implicated as the target for regulation by the ras gene product.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.39.24402

Quantitative analysis of the complex between p21ras and the Ras-binding domain of the human Raf-1 protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.39.24402

Three-dimensional structures of H-ras p21 mutants: molecular basis for their inability to function as signal switch molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.39.24402

21 January 2018

Phosphoinositide kinases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.39.24402

Specific activation of p85-p110 phosphatidylinositol 3'-kinase stimulates DNA synthesis by ras- and p70 S6 kinase-dependent pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.39.24402

Effect of the Activation of Phosphatidylinositol 3-Kinase by a Thiophosphotyrosine Peptide on Glucose Transport in 3T3-L1 Adipocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.39.24402

Differential effects of constitutively active phosphatidylinositol 3-kinase on glucose transport, glycogen synthase activity, and DNA synthesis in 3T3-L1 adipocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.39.24402

Membrane localization of phosphatidylinositol 3-kinase is sufficient to activate multiple signal-transducing kinase pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.39.24402

Phosphatidylinositol 3-kinase acts at an intracellular membrane site to enhance GLUT4 exocytosis in 3T3-L1 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.39.24402

Platelet-derived growth factor-dependent activation of phosphatidylinositol 3-kinase is regulated by receptor binding of SH2-domain-containing proteins which influence Ras activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.39.24402

Synergistic activation of c-fos promoter activity by Raf and Ral GDP dissociation stimulator

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.39.24402

Evidence for a Ras/Ral signaling cascade

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.39.24402

21 January 2018

Identifiers

DOI

10.1074/JBC.272.39.24402

1 reference

7 November 2017

1 reference