(Q42796335)

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Thrombin protease-activated receptor-1 signals through Gq- and G13-initiated MAPK cascades regulating c-Jun expression to induce cell transformation.

scientific article published on 3 September 2003

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scholarly article

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12954641%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

Thrombin protease-activated receptor-1 signals through Gq- and G13-initiated MAPK cascades regulating c-Jun expression to induce cell transformation (English)

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12954641%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

Joan Marc Servitja Duque

2

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7 November 2019

Stefan Offermanns

3

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7 November 2019

J. Silvio Gutkind

5

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7 November 2019

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Maria Julia Marinissen

1

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7 November 2019

Melvin I Simon

4

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7 November 2019

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3 September 2003

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7 November 2019

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12

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Journal of Biological Chemistry

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7 November 2019

278

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7 November 2019

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7 November 2019

46814-46825

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7 November 2019

Receptor protein-tyrosine kinases and their signal transduction pathways

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Thrombin and its receptor in growth control.

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Mutated alpha subunit of the Gq protein induces malignant transformation in NIH 3T3 cells

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A mutant alpha subunit of G12 potentiates the eicosanoid pathway and is highly oncogenic in NIH 3T3 cells

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21 January 2018

Biphasic increase in c-jun mRNA is required for induction of AP-1-mediated gene transcription: differential effects of muscarinic and thrombin receptor activation

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The jun and fos protein families are both required for cell cycle progression in fibroblasts

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Regulatory role of MEF2D in serum induction of the c-jun promoter

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21 January 2018

Mapping of epidermal growth factor-, serum-, and phorbol ester-responsive sequence elements in the c-jun promoter

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21 January 2018

Signaling from G protein-coupled receptors to the c-jun promoter involves the MEF2 transcription factor. Evidence for a novel c-jun amino-terminal kinase-independent pathway.

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21 January 2018

The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway

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21 January 2018

A network of mitogen-activated protein kinases links G protein-coupled receptors to the c-jun promoter: a role for c-Jun NH2-terminal kinase, p38s, and extracellular signal-regulated kinase 5.

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21 January 2018

Tyrosine phosphorylation of the vav proto-oncogene product links FcepsilonRI to the Rac1-JNK pathway

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Identification and characterization of a predominant isoform of human MKK3.

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21 January 2018

Multiple mitogen-activated protein kinase signaling pathways connect the cot oncoprotein to the c-jun promoter and to cellular transformation

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21 January 2018

Signaling from G protein-coupled receptors to ERK5/Big MAPK 1 involves Galpha q and Galpha 12/13 families of heterotrimeric G proteins. Evidence for the existence of a novel Ras AND Rho-independent pathway

1 reference

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21 January 2018

Substitution of three amino acids switches receptor specificity of Gq alpha to that of Gi alpha

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21 January 2018

Potent transforming activity of the G13 alpha subunit defines a novel family of oncogenes

1 reference

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21 January 2018

The thrombin receptor, PAR-1, causes transformation by activation of Rho-mediated signaling pathways

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Tissue factor- and factor X-dependent activation of protease-activated receptor 2 by factor VIIa

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Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions

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21 January 2018

Role of mitogen-activated protein kinases and c-Jun/AP-1 trans-activating activity in the regulation of protease mRNAs and the malignant phenotype in NIH 3T3 fibroblasts.

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G proteins: transducers of receptor-generated signals

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Heterotrimeric G proteins: organizers of transmembrane signals

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Genetic analysis of mammalian G-protein signalling.

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In vivo functions of heterotrimeric G-proteins: studies in Galpha-deficient mice.

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A cytoplasmic inhibitor of the JNK signal transduction pathway

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BMK1/ERK5 regulates serum-induced early gene expression through transcription factor MEF2C

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Binding of promoter-associated AP-1 is not altered during induction and subsequent repression of the c-jun promoter by TPA and UV irradiation.

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Identifiers

10.1074/JBC.M305709200

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12954641%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12954641%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

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