(Q42806438)

7 November 2017

title

FR177391, a new anti-hyperlipidemic agent from Serratia. IV. Target identification and validation by chemical genetic approaches (English)

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5-(5-Acetyloxy-10-chloro-6-methyl-3-oxo-2,14-dioxabicyclo[11.2.1]hexadeca-6,9-dien-15-yl)-5-hydroxy-3-methylpent-3-enoic acid

7 November 2017

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ChEBI release 2020-05-28

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Serratia liquefaciens

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Makiko Yamaoka

1

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7 November 2017

Kentaro Sato

2

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7 November 2017

Motoo Kobayashi

3

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7 November 2017

Nobuya Nishio

4

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7 November 2017

Mitsuru Ohkubo

5

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7 November 2017

Takashi Fujii

6

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7 November 2017

Hidenori Nakajima

7

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7 November 2017

publication date

1 October 2005

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full work available at URL

7 November 2017

https://www.nature.com/articles/ja200590.pdf

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19 March 2024

https://api.unpaywall.org/v2/10.1038/ja.2005.90?email=unpaywall_01@example.com

published in

The Journal of Antibiotics

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7 November 2017

volume

58

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7 November 2017

issue

10

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7 November 2017

page(s)

654-662

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https://api.unpaywall.org/v2/10.1038/ja.2005.90?email=unpaywall_01@example.com

7 November 2017

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19 March 2024

access restriction status

open access

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inferred from online access status

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Okadaic acid activates p42 mitogen-activated protein kinase (MAP kinase; ERK-2) in B-lymphocytes but inhibits rather than augments cellular proliferation: contrast with phorbol 12-myristate 13-acetate

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A receptor for the immunosuppressant FK506 is a cis-trans peptidyl-prolyl isomerase

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Two distinct signal transmission pathways in T lymphocytes are inhibited by complexes formed between an immunophilin and either FK506 or rapamycin

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Probing Immunosuppressant Action with a Nonnatural Immunophilin Ligand

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7 January 2021

Chemistry and Biology of the Immunophilins and Their Immunosuppressive Ligands

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7 January 2021

Immunophilin ligands demonstrate common features of signal transduction leading to exocytosis or transcription

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Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

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A mammalian protein targeted by G1-arresting rapamycin-receptor complex

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Control of p70 s6 kinase by kinase activity of FRAP in vivo

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Inhibition of proteasome activities and subunit-specific amino-terminal threonine modification by lactacystin

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A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p

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Depudecin induces morphological reversion of transformed fibroblasts via the inhibition of histone deacetylase

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Methionine aminopeptidase (type 2) is the common target for angiogenesis inhibitors AGM-1470 and ovalicin.

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The anti-angiogenic agent fumagillin covalently binds and inhibits the methionine aminopeptidase, MetAP-2

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7 January 2021

Leptomycin B inactivates CRM1/exportin 1 by covalent modification at a cysteine residue in the central conserved region

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7 January 2021

FR901228, a potent antitumor antibiotic, is a novel histone deacetylase inhibitor.

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New antitumor substances, FR901463, FR901464 and FR901465. II. Activities against experimental tumors in mice and mechanism of action

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7 January 2021

Identification of radicicol as an inhibitor of in vivo Ras/Raf interaction with the yeast two-hybrid screening system

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7 January 2021

High-performance affinity beads for identifying drug receptors

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7 January 2021

Compactin (ML-236B) and related compounds as potential cholesterol-lowering agents that inhibit HMG-CoA reductase

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7 January 2021

Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor

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7 January 2021

FR177391, a new anti-hyperlipidemic agent from Serratia. I. Taxonomy, fermentation, isolation, physico-chemical properties, structure elucidation and biological activities

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7 January 2021

FR177391, a new anti-hyperlipidemic agent from Serratia. II. Pharmacological activity of FR177391.

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7 January 2021

FR177391, A New Anti-hyperlipidemic Agent from Serratia

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7 January 2021

Mass Spectrometric Sequencing of Proteins from Silver-Stained Polyacrylamide Gels

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7 January 2021

The metabolic syndrome: peroxisome proliferator-activated receptor gamma and its therapeutic modulation

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7 January 2021

Peroxisome proliferator activated receptors and obesity

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7 January 2021

Thiazolidinediones in type 2 diabetes mellitus: current clinical evidence

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7 January 2021

New factors in the regulation of adipose differentiation and metabolism

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7 January 2021

Transcriptional activation of adipogenesis

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7 January 2021

From preadipocyte to adipocyte: differentiation-directed signals of insulin from the cell surface to the nucleus

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7 January 2021

PPAR-gamma: adipogenic regulator and thiazolidinedione receptor

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7 January 2021

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7 January 2021

TNF-alpha induction of lipolysis is mediated through activation of the extracellular signal related kinase pathway in 3T3-L1 adipocytes

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7 January 2021

Differentiation kinetics of in vitro 3T3-L1 preadipocyte cultures

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7 January 2021

Regulation of PPAR gamma transcriptional activity in 3T3-L1 adipocytes

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7 January 2021

Activation of MEK/ERK signaling promotes adipogenesis by enhancing peroxisome proliferator-activated receptor gamma (PPARgamma ) and C/EBPalpha gene expression during the differentiation of 3T3-L1 preadipocytes

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7 January 2021

Regulation of transcription factor mRNA accumulation during 3T3-L1 preadipocyte differentiation by antagonists of adipogenesis

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7 January 2021

Tumor necrosis factor alpha: a key component of the obesity-diabetes link

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7 January 2021

Rosiglitazone: a new therapy for Type 2 diabetes

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7 January 2021

A review of rosiglitazone in type 2 diabetes mellitus

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7 January 2021

Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling

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7 January 2021

Identifiers

DOI

10.1038/JA.2005.90

1 reference

7 November 2017

1 reference