(Q42807565)

7 November 2017

title

Ras stimulates DNA topoisomerase II alpha through MEK: a link between oncogenic signaling and a therapeutic target (English)

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7 November 2017

Chen G

1

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7 November 2017

Templeton D

series ordinal

2

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7 November 2017

Suttle DP

series ordinal

3

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7 November 2017

Stacey DW

series ordinal

4

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7 November 2017

language of work or name

English

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publication date

1 November 1999

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7 November 2017

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7 November 2017

volume

18

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7 November 2017

issue

50

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7 November 2017

page(s)

7149-7160

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PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo

7 November 2017

cites work

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203149

Structure and mechanism of DNA topoisomerase II

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203149

Chromatid segregation at anaphase requires the barren product, a novel chromosome-associated protein that interacts with Topoisomerase II.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203149

Induction of mitogen-activated protein kinase phosphatase 1 by the stress-activated protein kinase signaling pathway but not by extracellular signal-regulated kinase in fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203149

DNA topoisomerases: essential enzymes and lethal targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203149

Oncogenic transformation potentiates apoptosis, S-phase arrest and stress-kinase activation by etoposide

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203149

p120 GAP modulates Ras activation of Jun kinases and transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203149

Regulation of mitogen-activated protein kinase phosphatase-1 expression by extracellular signal-related kinase-dependent and Ca2+-dependent signal pathways in Rat-1 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203149

The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203149

A topoisomerase II-dependent G2 cycle checkpoint in mammalian cells/.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203149

A raf-independent epidermal growth factor receptor autocrine loop is necessary for Ras transformation of rat intestinal epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203149

Ras-mediated transcription activation: analysis by transient cotransfection assays

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203149

DNA topoisomerase II is required at the time of mitosis in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203149

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203149

Mitogenic signaling mediated by oxidants in Ras-transformed fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203149

Regulation of the human topoisomerase IIalpha gene promoter in confluence-arrested cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203149

Cellular transformation and malignancy induced by ras require c-jun

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203149

The stress-activated protein kinase subfamily of c-Jun kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203149

A divergence in the MAP kinase regulatory network defined by MEK kinase and Raf

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203149

Identification of a dual specificity kinase that activates the Jun kinases and p38-Mpk2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203149

Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203149

Rapid phosphorylation of Ets-2 accompanies mitogen-activated protein kinase activation and the induction of heparin-binding epidermal growth factor gene expression by oncogenic Raf-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203149

Selective activation of the JNK signaling cascadeand c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203149

Differential activation of ERK and JNK mitogen-activated protein kinases by Raf-1 and MEKK

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203149

Requirement for ras proto-oncogene function during serum-stimulated growth of NIH 3T3 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203149

Direct interaction between Ras and the kinase domain of mitogen-activated protein kinase kinase kinase (MEKK1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203149

p53 regulates the minimal promoter of the human topoisomerase IIalpha gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203149

Requirement for c-ras proteins during viral oncogene transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203149

Dominant inhibitory Ras mutants selectively inhibit the activity of either cellular or oncogenic Ras.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203149

Transformation of NIH 3T3 cells by microinjection of Ha-ras p21 protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203149

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203149

Inhibition of DNA topoisomerase II alpha gene expression by the p53 tumor suppressor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203149

Structure and function of type II DNA topoisomerases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203149

Oncogenic Ras activates c-Jun via a separate pathway from the activation of extracellular signal-regulated kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203149

Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203149

Activation of stress-activated protein kinase by MEKK1 phosphorylation of its activator SEK1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203149

Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203149

Microinjection of the ras oncogene protein into PC12 cells induces morphological differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203149

7 January 2021

Proteins regulating Ras and its relatives

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203149

7 January 2021

The role of c-Jun N-terminal kinase (JNK) in apoptosis induced by ultraviolet C and gamma radiation. Duration of JNK activation may determine cell death and proliferation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203149

7 January 2021

Gene splicing by overlap extension

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203149

7 January 2021

Role of mitogen-activated protein kinase phosphatase during the cellular response to genotoxic stress. Inhibition of c-Jun N-terminal kinase activity and AP-1-dependent gene activation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203149

7 January 2021

The adenovirus E1A protein overrides the requirement for cellular ras in initiating DNA synthesis.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203149

7 January 2021

Ras is essential for nerve growth factor- and phorbol ester-induced tyrosine phosphorylation of MAP kinases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203149

7 January 2021

Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203149

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1203149

1 reference

Dimensions Publication ID

7 November 2017

1024088893

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1 reference