(Q42813304)

English

mTORC2 protein complex-mediated Akt (Protein Kinase B) Serine 473 Phosphorylation is not required for Akt1 activity in human platelets [corrected].

scientific article published on 18 May 2011

In more languages

Statements

scholarly article

1 reference

Europe PubMed Central

7 November 2017

mTORC2 protein complex-mediated Akt (Protein Kinase B) Serine 473 Phosphorylation is not required for Akt1 activity in human platelets [corrected]. (English)

1 reference

Europe PubMed Central

7 November 2017

phosphorylation

1 reference

based on heuristic

inferred from title

author name string

Samantha F Moore

1

1 reference

Europe PubMed Central

7 November 2017

Roger W Hunter

2

1 reference

Europe PubMed Central

7 November 2017

Ingeborg Hers

3

1 reference

Europe PubMed Central

7 November 2017

language of work or name

0 references

publication date

18 May 2011

1 reference

Europe PubMed Central

7 November 2017

Journal of Biological Chemistry

1 reference

Europe PubMed Central

7 November 2017

286

1 reference

Europe PubMed Central

7 November 2017

28

1 reference

Europe PubMed Central

7 November 2017

24553-24560

1 reference

Europe PubMed Central

7 November 2017

Discovery of 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1H)-one as a highly potent, selective mammalian target of rapamycin (mTOR) inhibitor for the treatment of cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3137030

27 May 2018

Protein kinase B (PKB/Akt), a key mediator of the PI3K signaling pathway

1 reference

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Fat cell-specific ablation of rictor in mice impairs insulin-regulated fat cell and whole-body glucose and lipid metabolism

1 reference

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Biochemical, cellular, and in vivo activity of novel ATP-competitive and selective inhibitors of the mammalian target of rapamycin

1 reference

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Ku-0063794 is a specific inhibitor of the mammalian target of rapamycin (mTOR)

1 reference

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27 May 2018

PIKKing on PKB: regulation of PKB activity by phosphorylation

1 reference

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27 May 2018

Protein kinase C-mediated phosphorylation and activation of PDE3A regulate cAMP levels in human platelets.

1 reference

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Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2

1 reference

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27 May 2018

An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1

1 reference

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27 May 2018

Potentiation and priming of platelet activation: a potential target for antiplatelet therapy

1 reference

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Regulation of proline-rich Akt substrate of 40 kDa (PRAS40) function by mammalian target of rapamycin complex 1 (mTORC1)-mediated phosphorylation

1 reference

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Characterization of a protein kinase B inhibitor in vitro and in insulin-treated liver cells

1 reference

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27 May 2018

PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms

1 reference

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27 May 2018

Physiological roles of PKB/Akt isoforms in development and disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3137030

27 May 2018

Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3137030

27 May 2018

mTOR-dependent synthesis of Bcl-3 controls the retraction of fibrin clots by activated human platelets.

1 reference

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27 May 2018

S6K1 regulates GSK3 under conditions of mTOR-dependent feedback inhibition of Akt.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3137030

27 May 2018

Multiallelic disruption of the rictor gene in mice reveals that mTOR complex 2 is essential for fetal growth and viability

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3137030

27 May 2018

SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3137030

27 May 2018

Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3137030

27 May 2018

Regulation of the Akt kinase by interacting proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3137030

27 May 2018

Thrombopoietin complements G(i)- but not G(q)-dependent pathways for integrin {alpha}(IIb){beta}(3) activation and platelet aggregation

1 reference

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27 May 2018

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

1 reference

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Mechanism of feedback regulation of insulin receptor substrate-1 phosphorylation in primary adipocytes

1 reference

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Role of Gas6 receptors in platelet signaling during thrombus stabilization and implications for antithrombotic therapy

1 reference

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Impaired platelet responses to thrombin and collagen in AKT-1-deficient mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3137030

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Defects in secretion, aggregation, and thrombus formation in platelets from mice lacking Akt2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3137030

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Multiple phosphoinositide 3-kinase-dependent steps in activation of protein kinase B

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3137030

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GSK3 takes centre stage more than 20 years after its discovery

1 reference

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p38 Kinase-dependent MAPKAPK-2 activation functions as 3-phosphoinositide-dependent kinase-2 for Akt in human neutrophils

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3137030

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PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3137030

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Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase

1 reference

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27 May 2018

Role of translocation in the activation and function of protein kinase B

1 reference

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27 May 2018

Molecular basis for the substrate specificity of protein kinase B; comparison with MAPKAP kinase-1 and p70 S6 kinase

1 reference

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Mechanism of activation of protein kinase B by insulin and IGF-1

1 reference

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27 May 2018

Insulin/IGF-1 hybrid receptor expression on human platelets: consequences for the effect of insulin on platelet function

1 reference

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16 August 2018

Effects of the cAMP-elevating agents cilostamide, cilostazol and forskolin on the phosphorylation of Akt and GSK-3beta in platelets.

1 reference

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16 August 2018

mTOR.RICTOR is the Ser473 kinase for Akt/protein kinase B in 3T3-L1 adipocytes

1 reference

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16 August 2018

Regulation of glycogen synthase kinase 3 in human platelets: a possible role in platelet function?

1 reference

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16 August 2018

Insulin-like growth factor-1 potentiates platelet activation via the IRS/PI3Kalpha pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/21592956

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The PKB inhibitor Akti-1/2 potentiates PAR-1-mediated platelet function independently of its ability to block PKB

1 reference

https://pubmed.ncbi.nlm.nih.gov/21592956

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Thrombopoietin potentiates collagen receptor signaling in platelets through a phosphatidylinositol 3-kinase-dependent pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/21592956

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dual regulation of platelet protein kinase B

1 reference

https://pubmed.ncbi.nlm.nih.gov/21592956

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M110.202341

1 reference

Europe PubMed Central

7 November 2017

1 reference

Europe PubMed Central

7 November 2017

1 reference

Europe PubMed Central

7 November 2017

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