(Q42828663)

8 November 2017

title

Acetylation of Smad2 by the co-activator p300 regulates activin and transforming growth factor beta response (English)

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8 November 2017

Andrea W Tu

1

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8 November 2017

Kunxin Luo

series ordinal

2

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8 November 2017

language of work or name

English

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publication date

3 May 2007

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Journal of Biological Chemistry

8 November 2017

published in

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8 November 2017

volume

282

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8 November 2017

issue

29

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8 November 2017

page(s)

21187-21196

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Specificity and versatility in tgf-beta signaling through Smads

8 November 2017

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Postgastrulation Smad2-deficient embryos show defects in embryo turning and anterior morphogenesis

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Smad2 signaling in extraembryonic tissues determines anterior-posterior polarity of the early mouse embryo

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Targeted disruption of Smad3 reveals an essential role in transforming growth factor beta-mediated signal transduction

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Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-beta

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Smad transcription factors

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The transcriptional coactivators p300 and CBP are histone acetyltransferases

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25 years after the nucleosome model: chromatin modifications

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Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain

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Acetylation of beta-catenin by CREB-binding protein (CBP).

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Control of Smad7 stability by competition between acetylation and ubiquitination

21 January 2018

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Acetylation of the adenovirus-transforming protein E1A determines nuclear localization by disrupting association with importin-alpha

21 January 2018

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Acetylation of p53 inhibits its ubiquitination by Mdm2.

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The balance between acetylation and deacetylation controls Smad7 stability.

21 January 2018

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21 January 2018

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21 January 2018

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An essential role for Mad homology domain 1 in the association of Smad3 with histone deacetylase activity*.

21 January 2018

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Smads orchestrate specific histone modifications and chromatin remodeling to activate transcription

21 January 2018

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The DNA binding activities of Smad2 and Smad3 are regulated by coactivator-mediated acetylation.

21 January 2018

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Transcription elongation factor P-TEFb mediates Tat activation of HIV-1 transcription at multiple stages

21 January 2018

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Negative feedback regulation of TGF-beta signaling by the SnoN oncoprotein

21 January 2018

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The Ski oncoprotein interacts with the Smad proteins to repress TGFbeta signaling

21 January 2018

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Requirement for the SnoN oncoprotein in transforming growth factor beta-induced oncogenic transformation of fibroblast cells

21 January 2018

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Cytoplasmic SnoN in normal tissues and nonmalignant cells antagonizes TGF-beta signaling by sequestration of the Smad proteins

21 January 2018

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Functional characterization of transforming growth factor beta signaling in Smad2- and Smad3-deficient fibroblasts

21 January 2018

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Transforming growth factor beta-independent shuttling of Smad4 between the cytoplasm and nucleus.

21 January 2018

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Nucleocytoplasmic shuttling of Smads 2, 3, and 4 permits sensing of TGF-beta receptor activity

21 January 2018

1 reference

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Kinetic analysis of Smad nucleocytoplasmic shuttling reveals a mechanism for transforming growth factor beta-dependent nuclear accumulation of Smads

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700085200

PPM1A functions as a Smad phosphatase to terminate TGFbeta signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700085200

Smad2 nucleocytoplasmic shuttling by nucleoporins CAN/Nup214 and Nup153 feeds TGFbeta signaling complexes in the cytoplasm and nucleus

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700085200

Mice exclusively expressing the short isoform of Smad2 develop normally and are viable and fertile.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700085200

21 January 2018

Identifiers

DOI

10.1074/JBC.M700085200

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8 November 2017

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