(Q42834452)

8 November 2017

title

Mechanisms of guanine nucleotide exchange and Rac-mediated signaling revealed by a dominant negative trio mutant (English)

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8 November 2017

Balazs Debreceni

1

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8 November 2017

Yuan Gao

2

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8 November 2017

Fukun Guo

3

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8 November 2017

Kejin Zhu

4

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8 November 2017

Baoqing Jia

5

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8 November 2017

Yi Zheng

6

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8 November 2017

language of work or name

English

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publication date

3 November 2003

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Journal of Biological Chemistry

8 November 2017

published in

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8 November 2017

volume

279

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8 November 2017

issue

5

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8 November 2017

page(s)

3777-3786

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Rho GTPases and signaling networks

8 November 2017

cites work

1 reference

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Guanine nucleotide exchange factors for Rho GTPases: turning on the switch

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Rho family GTPases: more than simple switches

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The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

21 January 2018

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An Essential Role for Rho, Rac, and Cdc42 GTPases in Cell Cycle Progression Through G 1

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An essential role for Rac in Ras transformation

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A role for Rho in Ras transformation

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Cdc42 regulates anchorage-independent growth and is necessary for Ras transformation

21 January 2018

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Tools of the trade: use of dominant-inhibitory mutants of Ras-family GTPases

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Identification of Rho GTPase-dependent sites in the Dbl homology domain of oncogenic Dbl that are required for transformation

21 January 2018

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Regulation of proto-Dbl by intracellular membrane targeting and protein stability

21 January 2018

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Residues of the Rho family GTPases Rho and Cdc42 that specify sensitivity to Dbl-like guanine nucleotide exchange factors.

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21 January 2018

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Production of high-titer helper-free retroviruses by transient transfection

21 January 2018

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Localization of the PAK1-, WASP-, and IQGAP1-specifying regions of Cdc42.

21 January 2018

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Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeleton

21 January 2018

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A novel Cdc42Hs mutant induces cellular transformation

21 January 2018

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Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

21 January 2018

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Faciogenital dysplasia protein (FGD1) and Vav, two related proteins required for normal embryonic development, are upstream regulators of Rho GTPases

21 January 2018

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alphaPix stimulates p21-activated kinase activity through exchange factor-dependent and -independent mechanisms

21 January 2018

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Structure and mutagenesis of the Dbl homology domain

21 January 2018

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NMR structure and mutagenesis of the N-terminal Dbl homology domain of the nucleotide exchange factor Trio

21 January 2018

1 reference

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Crystal structure of Rac1 in complex with the guanine nucleotide exchange region of Tiam1

21 January 2018

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A crystallographic view of interactions between Dbs and Cdc42: PH domain-assisted guanine nucleotide exchange

21 January 2018

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Structural basis for the selective activation of Rho GTPases by Dbl exchange factors

21 January 2018

1 reference

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The multidomain protein Trio binds the LAR transmembrane tyrosine phosphatase, contains a protein kinase domain, and has separate rac-specific and rho-specific guanine nucleotide exchange factor domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308282200

The two guanine nucleotide exchange factor domains of Trio link the Rac1 and the RhoA pathways in vivo

21 January 2018

1 reference

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A glutamic finger in the guanine nucleotide exchange factor ARNO displaces Mg2+ and the beta-phosphate to destabilize GDP on ARF1.

21 January 2018

1 reference

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Structures of Cdc42 bound to the active and catalytically compromised forms of Cdc42GAP

21 January 2018

1 reference

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The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308282200

Inhibition of NIH 3T3 cell proliferation by a mutant ras protein with preferential affinity for GDP.

21 January 2018

1 reference

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RhoGEF specificity mutants implicate RhoA as a target for Dbs transforming activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308282200

UNC-73 activates the Rac GTPase and is required for cell and growth cone migrations in C. elegans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308282200

Specific contributions of the small GTPases Rho, Rac, and Cdc42 to Dbl transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308282200

The role of Mg2+ cofactor in the guanine nucleotide exchange and GTP hydrolysis reactions of Rho family GTP-binding proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308282200

21 January 2018

Identifiers

DOI

10.1074/JBC.M308282200

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8 November 2017

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