(Q42874830)

9 November 2017

title

ATM kinase activity modulates cFLIP protein levels: potential interplay between DNA damage signalling and TRAIL-induced apoptosis (English)

1 reference

9 November 2017

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Venturina Stagni

1

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9 November 2017

Michele Mingardi

2

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9 November 2017

Simonetta Santini

3

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9 November 2017

Danilo Giaccari

4

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9 November 2017

Daniela Barilà

5

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9 November 2017

language of work or name

English

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publication date

27 September 2010

1 reference

full work available at URL

9 November 2017

https://academic.oup.com/carcin/article-pdf/31/11/1956/17287639/bgq193.pdf

file format

Portable Document Format

online access status

open access

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20876284

http://carcin.oxfordjournals.org/cgi/content/abstract/31/11/1956

21 July 2024

online access status

open access

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20876284

http://academic.oup.com/carcin/article-pdf/31/11/1956/17287639/bgq193.pdf

21 July 2024

file format

Portable Document Format

1 reference

https://api.crossref.org/works/10.1093/CARCIN/BGQ193

21 July 2024

1 reference

9 November 2017

volume

31

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9 November 2017

issue

11

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9 November 2017

page(s)

1956-1963

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Identification and characterization of a new member of the TNF family that induces apoptosis

9 November 2017

cites work

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Barriers to effective TRAIL-targeted therapy of malignancy

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TRAIL signalling: decisions between life and death.

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FLIP and the death effector domain family

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Expression of the cellular FLICE-inhibitory protein (c-FLIP) protects Hodgkin's lymphoma cells from autonomous Fas-mediated death

21 July 2024

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c-FLIP mediates resistance of Hodgkin/Reed-Sternberg cells to death receptor-induced apoptosis

21 July 2024

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Enhanced caspase-8 recruitment to and activation at the DISC is critical for sensitisation of human hepatocellular carcinoma cells to TRAIL-induced apoptosis by chemotherapeutic drugs.

21 July 2024

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https://api.crossref.org/works/10.1093/CARCIN/BGQ193

Preclinical differentiation between apparently safe and potentially hepatotoxic applications of TRAIL either alone or in combination with chemotherapeutic drugs.

21 July 2024

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Regulation of lymphocyte proliferation and death by FLIP.

21 July 2024

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Shared pathways: death receptors and cytotoxic drugs in cancer therapy

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https://api.crossref.org/works/10.1093/CARCIN/BGQ193

Cellular FLICE-like inhibitory protein (C-FLIP): a novel target for cancer therapy

21 July 2024

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https://api.crossref.org/works/10.1093/CARCIN/BGQ193

ATM kinase activity modulates Fas sensitivity through the regulation of FLIP in lymphoid cells.

21 July 2024

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Nuclear ataxia-telangiectasia mutated (ATM) mediates the cellular response to DNA double strand breaks in human neuron-like cells

21 July 2024

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A system for stable expression of short interfering RNAs in mammalian cells

21 July 2024

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Molecular characterization of the thermosensitive E1 ubiquitin-activating enzyme cell mutant A31N-ts20. Requirements upon different levels of E1 for the ubiquitination/degradation of the various protein substrates in vivo

21 July 2024

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https://api.crossref.org/works/10.1093/CARCIN/BGQ193

Caspase-dependent cleavage of c-Abl contributes to apoptosis

21 July 2024

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Accelerated degradation of cellular FLIP protein through the ubiquitin-proteasome pathway in p53-mediated apoptosis of human cancer cells

21 July 2024

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Chemotherapy and TRAIL-mediated colon cancer cell death: the roles of p53, TRAIL receptors, and c-FLIP.

21 July 2024

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Enhanced phosphorylation of p53 by ATM in response to DNA damage

21 July 2024

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https://api.crossref.org/works/10.1093/CARCIN/BGQ193

ATM associates with and phosphorylates p53: mapping the region of interaction

21 July 2024

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https://api.crossref.org/works/10.1093/CARCIN/BGQ193

Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM

21 July 2024

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Histone deacetylase inhibitors potentiate TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in lymphoid malignancies.

21 July 2024

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Modulation of TRAIL-induced apoptosis by HDAC inhibitors

21 July 2024

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The proteasome inhibitor PS-341 sensitizes neoplastic cells to TRAIL-mediated apoptosis by reducing levels of c-FLIP.

21 July 2024

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A new TRAIL to therapy of hepatocellular carcinoma: blocking the proteasome

21 July 2024

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TRAIL/bortezomib cotreatment is potentially hepatotoxic but induces cancer-specific apoptosis within a therapeutic window.

21 July 2024

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Bortezomib induces caspase-dependent apoptosis in Hodgkin lymphoma cell lines and is associated with reduced c-FLIP expression: a gene expression profiling study with implications for potential combination therapies

21 July 2024

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Inhibition of ataxia telangiectasia mutated kinase activity enhances TRAIL-mediated apoptosis in human melanoma cells

21 July 2024

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https://api.crossref.org/works/10.1093/CARCIN/BGQ193

Cisplatin induces p53-dependent FLICE-like inhibitory protein ubiquitination in ovarian cancer cells.

21 July 2024

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https://api.crossref.org/works/10.1093/CARCIN/BGQ193

Radiation and anticancer drugs can facilitate mitochondrial bypass by CD95/Fas via c-FLIP downregulation

21 July 2024

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https://api.crossref.org/works/10.1093/CARCIN/BGQ193

c-FLIP inhibits chemotherapy-induced colorectal cancer cell death

21 July 2024

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https://api.crossref.org/works/10.1093/CARCIN/BGQ193

Doxorubicin generates a proapoptotic phenotype by phosphorylation of elongation factor 2.

21 July 2024

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https://api.crossref.org/works/10.1093/CARCIN/BGQ193

Ubiquitination capabilities in response to neocarzinostatin and H(2)O(2) stress in cell lines from patients with ataxia-telangiectasia

21 July 2024

35

1 reference

https://api.crossref.org/works/10.1093/CARCIN/BGQ193

ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage

21 July 2024

36

1 reference

https://api.crossref.org/works/10.1093/CARCIN/BGQ193

A proteomic analysis of ataxia telangiectasia-mutated (ATM)/ATM-Rad3-related (ATR) substrates identifies the ubiquitin-proteasome system as a regulator for DNA damage checkpoints.

21 July 2024

37

1 reference

https://api.crossref.org/works/10.1093/CARCIN/BGQ193

Molecular linkage between the kinase ATM and NF-kappaB signaling in response to genotoxic stimuli

21 July 2024

38

1 reference

https://api.crossref.org/works/10.1093/CARCIN/BGQ193

ATM engages autodegradation of the E3 ubiquitin ligase COP1 after DNA damage

21 July 2024

39

1 reference

https://api.crossref.org/works/10.1093/CARCIN/BGQ193

ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage

21 July 2024

40

1 reference

https://api.crossref.org/works/10.1093/CARCIN/BGQ193

The E3 ubiquitin ligase itch couples JNK activation to TNFalpha-induced cell death by inducing c-FLIP(L) turnover

21 July 2024

41

1 reference

https://api.crossref.org/works/10.1093/CARCIN/BGQ193

Proapoptotic BID is an ATM effector in the DNA-damage response

21 July 2024

42

1 reference

https://api.crossref.org/works/10.1093/CARCIN/BGQ193

A role for proapoptotic BID in the DNA-damage response

21 July 2024

43

1 reference

https://api.crossref.org/works/10.1093/CARCIN/BGQ193

21 July 2024

Identifiers

1 reference

9 November 2017

1 reference