(Q42962588)

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Meeting report: metabolites in safety testing (MIST) symposium-safety assessment of human metabolites: what's REALLY necessary to ascertain exposure coverage in safety tests?

scientific article published on 3 July 2013

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

11 November 2017

0 references

Meeting report: metabolites in safety testing (MIST) symposium-safety assessment of human metabolites: what's REALLY necessary to ascertain exposure coverage in safety tests? (English)

1 reference

Europe PubMed Central

PMC publication ID

11 November 2017

exposure assessment

1 reference

based on heuristic

inferred from title

author name string

Hongying Gao

1

1 reference

Europe PubMed Central

PMC publication ID

11 November 2017

Abigail Jacobs

2

1 reference

Europe PubMed Central

PMC publication ID

11 November 2017

Ronald E White

3

1 reference

Europe PubMed Central

PMC publication ID

11 November 2017

Brian P Booth

4

1 reference

Europe PubMed Central

PMC publication ID

11 November 2017

R Scott Obach

5

1 reference

Europe PubMed Central

PMC publication ID

11 November 2017

language of work or name

0 references

publication date

3 July 2013

1 reference

Europe PubMed Central

PMC publication ID

11 November 2017

The AAPS Journal

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Europe PubMed Central

PMC publication ID

11 November 2017

15

1 reference

Europe PubMed Central

PMC publication ID

11 November 2017

4

1 reference

Europe PubMed Central

PMC publication ID

11 November 2017

970-973

1 reference

Europe PubMed Central

PMC publication ID

11 November 2017

https://scigraph.springernature.com/pub.10.1208/s12248-013-9502-6

0 references

Determination of exposure multiples of human metabolites for MIST assessment in preclinical safety species without using reference standards or radiolabeled compounds

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3787210

26 May 2018

Drug metabolites in safety testing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3787210

26 May 2018

Best practices in a tiered approach to metabolite quantification: views and recommendations of the European Bioanalysis Forum.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3787210

16 August 2018

A Simple Liquid Chromatography-Tandem Mass Spectrometry Method to Determine Relative Plasma Exposures of Drug Metabolites across Species for Metabolite Safety Assessments

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3787210

16 August 2018

Obtaining exposures of metabolites in preclinical species through plasma pooling and quantitative NMR: addressing metabolites in safety testing (MIST) guidance without using radiolabeled compounds and chemically synthesized metabolite standards.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3787210

16 August 2018

Nuclear magnetic resonance spectroscopy as a quantitative tool to determine the concentrations of biologically produced metabolites: implications in metabolites in safety testing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3787210

16 August 2018

A simple liquid chromatography-tandem mass spectrometry method to determine relative plasma exposures of drug metabolites across species for metabolite safety assessments (metabolites in safety testing). II. Application to unstable metabolites

1 reference

https://pubmed.ncbi.nlm.nih.gov/23821354

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Drug metabolites in safety testing

1 reference

https://pubmed.ncbi.nlm.nih.gov/23821354

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabolites and safety: What are the concerns, and how should we address them?

1 reference

https://pubmed.ncbi.nlm.nih.gov/23821354

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A rapid method for quantitatively estimating metabolites in human plasma in the absence of synthetic standards using a combination of liquid chromatography/mass spectrometry and radiometric detection

1 reference

https://pubmed.ncbi.nlm.nih.gov/23821354

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Addressing MIST (Metabolites in Safety Testing): bioanalytical approaches to address metabolite exposures in humans and animals.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23821354

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

LC-MS/MS-based approach for obtaining exposure estimates of metabolites in early clinical trials using radioactive metabolites as reference standards

1 reference

https://pubmed.ncbi.nlm.nih.gov/23821354

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A radiocalibration method with pseudo internal standard to estimate circulating metabolite concentrations

1 reference

https://pubmed.ncbi.nlm.nih.gov/23821354

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Validation of isolated metabolites from drug metabolism studies as analytical standards by quantitative NMR

1 reference

https://pubmed.ncbi.nlm.nih.gov/23821354

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1208/S12248-013-9502-6

1 reference

Europe PubMed Central

PMC publication ID

11 November 2017

Dimensions Publication ID

0 references

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

11 November 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

11 November 2017

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