(Q42972123)

English

An improved nonlinear model describing the hepatic pharmacokinetics of digoxin: evidence for two functionally different uptake systems and saturable binding

scientific article published on 13 July 2010

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

12 November 2017

An improved nonlinear model describing the hepatic pharmacokinetics of digoxin: evidence for two functionally different uptake systems and saturable binding (English)

1 reference

Europe PubMed Central

PubMed publication ID

12 November 2017

0 references

pharmacokinetics

1 reference

based on heuristic

inferred from title

Michael S. Roberts

3

1 reference

Europe PubMed Central

PubMed publication ID

12 November 2017

author name string

Michael Weiss

1

1 reference

Europe PubMed Central

PubMed publication ID

12 November 2017

Peng Li

2

1 reference

Europe PubMed Central

PubMed publication ID

12 November 2017

publication date

13 July 2010

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Europe PubMed Central

PubMed publication ID

12 November 2017

Pharmaceutical Research

1 reference

Europe PubMed Central

PubMed publication ID

12 November 2017

27

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Europe PubMed Central

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12 November 2017

9

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Europe PubMed Central

PubMed publication ID

12 November 2017

1999-2007

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Europe PubMed Central

PubMed publication ID

12 November 2017

Kinetic analysis of saturable hepatic uptake of digoxin and its inhibition by rifampicin

1 reference

https://pubmed.ncbi.nlm.nih.gov/20625800

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hepatic Na(+)-K(+)-ATPase enzyme activity correlates with polarized beta-subunit expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/20625800

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Systems analysis of digoxin kinetics and inotropic response in the rat heart: effects of calcium and KB-R7943.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20625800

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Population approaches to estimate minimal model indexes of insulin sensitivity and glucose effectiveness using full and reduced sampling schedules.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20625800

12 December 2020

based on heuristic

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Increased (Na+,K+)-ATPase concentrations in various tissues of rats caused by thyroid hormone treatment

1 reference

https://pubmed.ncbi.nlm.nih.gov/20625800

12 December 2020

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Predominant contribution of rat organic anion transporting polypeptide-2 (Oatp2) to hepatic uptake of beta-lactam antibiotics

1 reference

https://pubmed.ncbi.nlm.nih.gov/20625800

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hepatic binding and Michaelis-Menten metabolism of drugs

1 reference

https://pubmed.ncbi.nlm.nih.gov/20625800

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional characterization of human organic anion transporting polypeptide B (OATP-B) in comparison with liver-specific OATP-C.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20625800

12 December 2020

based on heuristic

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The blood-brain barrier thyroxine transporter organic anion-transporting polypeptide 1c1 displays atypical transport kinetics

1 reference

https://pubmed.ncbi.nlm.nih.gov/20625800

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tissue-level modeling of xenobiotic metabolism in liver: An emerging tool for enabling clinical translational research

1 reference

https://pubmed.ncbi.nlm.nih.gov/20625800

12 December 2020

based on heuristic

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Mechanisms and kinetics of uptake and efflux of L-methionine in an intestinal epithelial model (Caco-2)

1 reference

https://pubmed.ncbi.nlm.nih.gov/20625800

12 December 2020

based on heuristic

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Hepatic uptake of the magnetic resonance imaging contrast agent gadoxetate by the organic anion transporting polypeptide Oatp1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20625800

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Vascular binding, blood flow, transporter, and enzyme interactions on the processing of digoxin in rat liver.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20625800

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Use of a monoclonal antibody to quantify (Na+,K+)-ATPase activity and sites in normal and regenerating rat liver

1 reference

https://pubmed.ncbi.nlm.nih.gov/20625800

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Isolation of a multispecific organic anion and cardiac glycoside transporter from rat brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/20625800

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A compartmental model of hepatic disposition kinetics: 1. Model development and application to linear kinetics

1 reference

https://pubmed.ncbi.nlm.nih.gov/20625800

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of 17 beta-estradiol-D-17 beta-glucuronide on the rat organic anion transporting polypeptide 2-mediated transport differs depending on substrates

1 reference

https://pubmed.ncbi.nlm.nih.gov/20625800

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The drug transporter-metabolism alliance: uncovering and defining the interplay

1 reference

https://pubmed.ncbi.nlm.nih.gov/20625800

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunocytochemical study of NA+ K(+)-ATPase alpha 1 and beta 1 subunits in human and rat normal hepatocytes using confocal microscopy

1 reference

https://pubmed.ncbi.nlm.nih.gov/20625800

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A rapid and sensitive LC/MS/MS assay for quantitative determination of digoxin in rat plasma

1 reference

https://pubmed.ncbi.nlm.nih.gov/20625800

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanism of thiamine transport in neuroblastoma cells. Inhibition of a high affinity carrier by sodium channel activators and dependence of thiamine uptake on membrane potential and intracellular ATP

1 reference

https://pubmed.ncbi.nlm.nih.gov/20625800

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Liver transporters in hepatic drug disposition: an update

1 reference

https://pubmed.ncbi.nlm.nih.gov/20625800

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Kinetic modeling of ouabain tissue distribution based on slow and saturable binding to Na,K-ATPase

1 reference

https://pubmed.ncbi.nlm.nih.gov/20625800

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Localization of organic anion transporting polypeptide 4 (Oatp4) in rat liver and comparison of its substrate specificity with Oatp1, Oatp2 and Oatp3.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20625800

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ex situ inhibition of hepatic uptake and efflux significantly changes metabolism: hepatic enzyme-transporter interplay

1 reference

https://pubmed.ncbi.nlm.nih.gov/20625800

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Digoxin uptake, receptor heterogeneity, and inotropic response in the isolated rat heart: a comprehensive kinetic model.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20625800

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An Optimized Model for Rat Liver Perfusion Studies

1 reference

https://pubmed.ncbi.nlm.nih.gov/20625800

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Simulation and prediction of in vivo drug metabolism in human populations from in vitro data

1 reference

https://pubmed.ncbi.nlm.nih.gov/20625800

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S11095-010-0204-9

1 reference

Europe PubMed Central

PubMed publication ID

12 November 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

12 November 2017

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