(Q43047940)

12 November 2017

The cyclophilin inhibitor alisporivir prevents hepatitis C virus-mediated mitochondrial dysfunction (English)

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12 November 2017

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5

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12 November 2017

Giovanni Quarato

1

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author name string

Annamaria D'Aprile

2

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12 November 2017

Bruno Gavillet

3

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12 November 2017

Grégoire Vuagniaux

4

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12 November 2017

Nazzareno Capitanio

6

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12 November 2017

Claudia Piccoli

7

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12 November 2017

language of work or name

English

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publication date

18 March 2012

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12 November 2017

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12 November 2017

55

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12 November 2017

5

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12 November 2017

1333-1343

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Global epidemiology of hepatitis C virus infection

12 November 2017

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Therapy of hepatitis C: from empiricism to eradication

21 January 2018

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21 January 2018

Cyclophilin inhibitors

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The non-immunosuppressive cyclosporin DEBIO-025 is a potent inhibitor of hepatitis C virus replication in vitro

21 January 2018

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Debio 025, a cyclophilin binding molecule, is highly efficient in clearing hepatitis C virus (HCV) replicon-containing cells when used alone or in combination with specifically targeted antiviral therapy for HCV (STAT-C) inhibitors

21 January 2018

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Structural basis for the non-immunosuppressive character of the cyclosporin A analogue Debio 025.

21 January 2018

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Multiple cyclophilins involved in different cellular pathways mediate HCV replication

21 January 2018

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Critical Role of Cyclophilin A and Its Prolyl-Peptidyl Isomerase Activity in the Structure and Function of the Hepatitis C Virus Replication Complex

21 January 2018

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DEB025 (Alisporivir) inhibits hepatitis C virus replication by preventing a cyclophilin A induced cis-trans isomerisation in domain II of NS5A

21 January 2018

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Cyclophilin D in mitochondrial pathophysiology

21 January 2018

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Mitochondrial membrane permeabilization in cell death

21 January 2018

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Signal transduction to the permeability transition pore.

21 January 2018

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The mitochondrial permeability transition pore and its involvement in cell death and in disease pathogenesis

21 January 2018

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Mitochondrial calcium and the permeability transition in cell death

21 January 2018

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Genetic and pharmacologic inhibition of mitochondrial-dependent necrosis attenuates muscular dystrophy

21 January 2018

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Cyclosporin A corrects mitochondrial dysfunction and muscle apoptosis in patients with collagen VI myopathies

21 January 2018

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Hepatitis C virus protein expression causes calcium-mediated mitochondrial bioenergetic dysfunction and nitro-oxidative stress

21 January 2018

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HCV infection induces mitochondrial bioenergetic unbalance: causes and effects

21 January 2018

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Continuous human cell lines inducibly expressing hepatitis C virus structural and nonstructural proteins

21 January 2018

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In vivo and in organello assessment of OXPHOS activities

21 January 2018

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Hepatitis C Virus-Linked Mitochondrial Dysfunction Promotes Hypoxia-Inducible Factor 1 -Mediated Glycolytic Adaptation

21 January 2018

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Opening of the mitochondrial permeability transition pore causes depletion of mitochondrial and cytosolic NAD+ and is a causative event in the death of myocytes in postischemic reperfusion of the heart.

21 January 2018

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Cyclophilin D modulates mitochondrial F0F1-ATP synthase by interacting with the lateral stalk of the complex

21 January 2018

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Calcium, ATP, and ROS: a mitochondrial love-hate triangle

21 January 2018

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Superoxide flashes in single mitochondria

21 January 2018

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The mitochondrial permeability transition, release of cytochrome c and cell death. Correlation with the duration of pore openings in situ

21 January 2018

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Hepatitis C virus core protein increases mitochondrial ROS production by stimulation of Ca2+ uniporter activity.

21 January 2018

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Hepatitis C virus NS5A and core proteins induce oxidative stress-mediated calcium signalling alterations in hepatocytes

21 January 2018

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Endoplasmic reticulum (ER) stress: hepatitis C virus induces an ER-nucleus signal transduction pathway and activates NF-kappaB and STAT-3.

21 January 2018

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Access of viral proteins to mitochondria via mitochondria-associated membranes

21 January 2018

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Fluctuations in mitochondrial membrane potential caused by repetitive gating of the permeability transition pore

21 January 2018

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The versatility of mitochondrial calcium signals: from stimulation of cell metabolism to induction of cell death

21 January 2018

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Hepatitis C virus infection and apoptosis

21 January 2018

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Viral control of mitochondrial apoptosis

21 January 2018

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Caspase inhibitors for the treatment of hepatitis C.

21 January 2018

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Cytochrome c: a catalyst and target of nitrite-hydrogen peroxide-dependent protein nitration

21 January 2018

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Temporal Proteome and Lipidome Profiles Reveal Hepatitis C Virus-Associated Reprogramming of Hepatocellular Metabolism and Bioenergetics

21 January 2018

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Hepatitis C Virus Stabilizes Hypoxia-Inducible Factor 1 and Stimulates the Synthesis of Vascular Endothelial Growth Factor

21 January 2018

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Hepatitis C Virus Proteins Induce Lipogenesis and Defective Triglyceride Secretion in Transgenic Mice

21 January 2018

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Cellular lipid droplets and hepatitis C virus life cycle

21 January 2018

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An evaluation of the cyclophilin inhibitor Debio 025 and its potential as a treatment for chronic hepatitis C

21 January 2018

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Inhibition of mitochondrial permeability transition improves functional recovery and reduces mortality following acute myocardial infarction in mice

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Glutathione depletion causes cytochrome c release even in the absence of cell commitment to apoptosis.

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1002/HEP.25514

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12 November 2017

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