(Q43103589)

13 November 2017

title

Rac1 is crucial for Ras-dependent skin tumor formation by controlling Pak1-Mek-Erk hyperactivation and hyperproliferation in vivo (English)

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13 November 2017

C Brakebusch

10

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author name string

Z Wang

1

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13 November 2017

E Pedersen

2

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13 November 2017

A Basse

3

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13 November 2017

T Lefever

4

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13 November 2017

K Peyrollier

5

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13 November 2017

S Kapoor

6

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13 November 2017

Q Mei

7

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13 November 2017

R Karlsson

8

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13 November 2017

A Chrostek-Grashoff

9

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13 November 2017

language of work or name

English

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publication date

12 April 2010

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13 November 2017

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13 November 2017

volume

29

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13 November 2017

issue

23

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13 November 2017

page(s)

3362-3373

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Stem cell depletion through epidermal deletion of Rac1.

13 November 2017

cites work

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https://api.crossref.org/works/10.1038%2FONC.2010.95

Requirement of Rac1 distinguishes follicular from interfollicular epithelial stem cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.95

Rac1 is crucial for hair follicle integrity but is not essential for maintenance of the epidermis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.95

Rac-PAK signaling stimulates extracellular signal-regulated kinase (ERK) activation by regulating formation of MEK1-ERK complexes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.95

A critical role for Rac1 in tumor progression of human colorectal adenocarcinoma cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.95

PDGF stimulates an increase in GTP-Rac via activation of phosphoinositide 3-kinase

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.95

Scaffolding function of PAK in the PDK1-Akt pathway

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.95

Defective Rac-mediated proliferation and survival after targeted mutation of the beta1 integrin cytodomain

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.95

Cdc42 and Rac1 induce integrin-mediated cell motility and invasiveness through PI(3)K.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.95

The protein kinase Pak3 positively regulates Raf-1 activity through phosphorylation of serine 338

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.95

Requirement for Rac1 in a K-ras induced lung cancer in the mouse.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.95

Mice deficient in the Rac activator Tiam1 are resistant to Ras-induced skin tumours.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.95

The Rac activator Tiam1 controls tight junction biogenesis in keratinocytes through binding to and activation of the Par polarity complex

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.95

Stem-cell hierarchy in skin cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.95

31 March 2020

RHO-GTPases and cancer

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.95

Functional roles of Akt signaling in mouse skin tumorigenesis.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.95

Akt deficiency impairs normal cell proliferation and suppresses oncogenesis in a p53-independent and mTORC1-dependent manner.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.95

PAK1 phosphorylation of MEK1 regulates fibronectin-stimulated MAPK activation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.95

Adhesion stimulates direct PAK1/ERK2 association and leads to ERK-dependent PAK1 Thr212 phosphorylation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.95

Rac guanosine triphosphatases represent integrating molecular therapeutic targets for BCR-ABL-induced myeloproliferative disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.95

Impaired epidermal wound healing in vivo upon inhibition or deletion of Rac1.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.95

Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.95

31 March 2020

Identifiers

DOI

10.1038/ONC.2010.95

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Dimensions Publication ID

13 November 2017

1026733814

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