(Q43109283)

14 November 2017

title

Gene therapy for dopamine replacement in Parkinson's disease (English)

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14 November 2017

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Anders Björklund

1

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author name string

Tomas Björklund

series ordinal

2

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14 November 2017

Deniz Kirik

series ordinal

3

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14 November 2017

language of work or name

English

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publication date

1 October 2009

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Science Translational Medicine

14 November 2017

published in

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14 November 2017

volume

1

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14 November 2017

issue

2

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14 November 2017

page(s)

2ps2

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On the presence of 3-hydroxytyramine in brain.

14 November 2017

cites work

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Arvid Carlsson: an early pioneer in translational medicine

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Continuous dopamine-receptor treatment of Parkinson's disease: scientific rationale and clinical implications

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Modification of central dopaminergic mechanisms by continuous levodopa therapy for advanced Parkinson's disease

21 January 2018

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Gene therapy for Parkinson's disease: an approach to the prevention or palliation of levodopa-associated motor complications

21 January 2018

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Focal striatal dopamine may potentiate dyskinesias in parkinsonian monkeys

21 January 2018

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Long-term clinical improvement in MPTP-lesioned primates after gene therapy with AAV-hAADC.

21 January 2018

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A dose-ranging study of AAV-hAADC therapy in Parkinsonian monkeys

21 January 2018

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Parkinson's Disease: Activity of L-Dopa Decarboxylase in Discrete Brain Regions

21 January 2018

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Long-term doxycycline-controlled expression of human tyrosine hydroxylase after direct adenovirus-mediated gene transfer to a rat model of Parkinson's disease.

21 January 2018

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Behavioral recovery in a primate model of Parkinson's disease by triple transduction of striatal cells with adeno-associated viral vectors expressing dopamine-synthesizing enzymes

21 January 2018

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Triple transduction with adeno-associated virus vectors expressing tyrosine hydroxylase, aromatic-L-amino-acid decarboxylase, and GTP cyclohydrolase I for gene therapy of Parkinson's disease

21 January 2018

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Unregulated cytosolic dopamine causes neurodegeneration associated with oxidative stress in mice

21 January 2018

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Reversal of motor impairments in parkinsonian rats by continuous intrastriatal delivery of L-dopa using rAAV-mediated gene transfer

21 January 2018

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Reversal of dyskinesias in an animal model of Parkinson's disease by continuous L-DOPA delivery using rAAV vectors

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3000350

Positron emission tomography imaging demonstrates correlation between behavioral recovery and correction of dopamine neurotransmission after gene therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3000350

Dopamine released from 5-HT terminals is the cause of L-DOPA-induced dyskinesia in parkinsonian rats

21 January 2018

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Gene therapy continues to mature and to face challenges

21 January 2018

1 reference

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10.1126/SCITRANSLMED.3000350

21 January 2018

Identifiers

DOI

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14 November 2017

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