(Q43144564)

14 November 2017

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title

Methotrexate--how does it really work? (English)

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14 November 2017

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Edwin S L Chan

1

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PubMed ID

20197777

14 November 2017

Bruce N Cronstein

series ordinal

2

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PubMed ID

20197777

14 November 2017

language of work or name

English

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publication date

1 March 2010

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Nature Reviews Rheumatology

14 November 2017

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14 November 2017

6

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14 November 2017

175-178

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14 November 2017

3

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https://scigraph.springernature.com/pub.10.1038/nrrheum.2010.5

14 November 2017

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cites work

Effect of folic or folinic acid supplementation on the toxicity and efficacy of methotrexate in rheumatoid arthritis: a forty-eight week, multicenter, randomized, double-blind, placebo-controlled study

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2010.5

Low-dose methotrexate: a mainstay in the treatment of rheumatoid arthritis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2010.5

Reduction of the efficacy of methotrexate by the use of folic acid: post hoc analysis from two randomized controlled studies

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2010.5

Pharmacogenetic and metabolite measurements are associated with clinical status in patients with rheumatoid arthritis treated with methotrexate: results of a multicentred cross sectional observational study

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2010.5

Immunosuppressive properties of methotrexate: apoptosis and clonal deletion of activated peripheral T cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2010.5

Antiproliferative effects of methotrexate on peripheral blood mononuclear cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2010.5

In vitro effects of methotrexate on peripheral blood monocytes: modulation by folinic acid and S-adenosylmethionine

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2010.5

Methotrexate and sulfasalazine promote adenosine release by a mechanism that requires ecto-5'-nucleotidase-mediated conversion of adenine nucleotides

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2010.5

Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2010.5

Adenosine potentiates mediator release from human lung mast cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2010.5

Purinergic regulation of bradykinin-induced plasma extravasation and adjuvant-induced arthritis in the rat.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2010.5

The antiinflammatory mechanism of methotrexate. Increased adenosine release at inflamed sites diminishes leukocyte accumulation in an in vivo model of inflammation.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2010.5

Methotrexate modulates the kinetics of adenosine in humans in vivo

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2010.5

Adenosine and methotrexate polyglutamate concentrations in patients with juvenile arthritis.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2010.5

Adenosine: a physiological modulator of superoxide anion generation by human neutrophils.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2010.5

Neutrophil-derived 5'-adenosine monophosphate promotes endothelial barrier function via CD73-mediated conversion to adenosine and endothelial A2B receptor activation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2010.5

Suppression of rheumatoid factor production by methotrexate in patients with rheumatoid arthritis. Evidence for differential influences of therapy and clinical status on IgM and IgA rheumatoid factor expression

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2010.5

The effect of liposomally conjugated methotrexate upon mediator release from human peripheral blood monocytes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2010.5

Methotrexate specifically modulates cytokine production by T cells and macrophages in murine collagen-induced arthritis (CIA): a mechanism for methotrexate-mediated immunosuppression

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2010.5

Methotrexate reduces inflammatory cell numbers, expression of monokines and of adhesion molecules in synovial tissue of patients with rheumatoid arthritis.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2010.5

Methotrexate action in rheumatoid arthritis: stimulation of cytokine inhibitor and inhibition of chemokine production by peripheral blood mononuclear cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2010.5

Effect of antiarthritic drugs on the enhanced interleukin-1 (IL-1) production by macrophages from adjuvant-induced arthritic (AA) rats

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2010.5

The effects of methotrexate on the production and activity of interleukin-1

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2010.5

Reduction of leukocyte and interleukin-1 beta concentrations in the synovial fluid of rheumatoid arthritis patients treated with methotrexate

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2010.5

Inhibition of leukotriene B4 synthesis in neutrophils from patients with rheumatoid arthritis by a single oral dose of methotrexate

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2010.5

Methotrexate metabolism analysis in blood and liver of rheumatoid arthritis patients. Association with hepatic folate deficiency and formation of polyglutamates

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2010.5

Ethanol-induced activation of adenine nucleotide turnover. Evidence for a role of acetate

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2010.5

Adenosine promotes wound healing and mediates angiogenesis in response to tissue injury via occupancy of A(2A) receptors.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2010.5

Adenosine A(2A) receptors play a role in the pathogenesis of hepatic cirrhosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2010.5

Coffee, tea, and mortality

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2010.5

Effect of caffeine consumption on efficacy of methotrexate in rheumatoid arthritis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2010.5

Neutrophil adherence to endothelium is enhanced via adenosine A1 receptors and inhibited via adenosine A2 receptors

31 March 2020

1 reference

12 December 2020

Discrepancy between 3H-thymidine uptake and cell cycle studies in stimulated lymphocyte cultures treated with methotrexate

1 reference

12 December 2020

Adenosine inhibits neutrophil vascular endothelial growth factor release and transendothelial migration via A2B receptor activation

1 reference

12 December 2020

Adenosine A1 receptor promotion of multinucleated giant cell formation by human monocytes: a mechanism for methotrexate-induced nodulosis in rheumatoid arthritis

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRRHEUM.2010.5

1 reference

14 November 2017

1 reference

PubMed ID

20197777