(Q43183475)

English

The thiazolobenzimidazole TBZE-029 inhibits enterovirus replication by targeting a short region immediately downstream from motif C in the nonstructural protein 2C.

scientific article published on 12 March 2008

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scholarly article

1 reference

Europe PubMed Central

15 November 2017

The thiazolobenzimidazole TBZE-029 inhibits enterovirus replication by targeting a short region immediately downstream from motif C in the nonstructural protein 2C. (English)

1 reference

Europe PubMed Central

15 November 2017

9

object named as

Alba Chimirri

0 references

object named as

Erik De Clercq

8

0 references

object named as

Johan Neyts

13

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7

object named as

Bruno Canard

1 reference

Europe PubMed Central

15 November 2017

Frank J. M. van Kuppeveld

12

object named as

Frank van Kuppeveld

1 reference

Europe PubMed Central

15 November 2017

Ward Heggermont

2

object named as

Ward Heggermont

1 reference

Europe PubMed Central

15 November 2017

Gerhard Pürstinger

10

object named as

Gerhard Pürstinger

1 reference

Europe PubMed Central

15 November 2017

Anna-Maria Monforte

6

object named as

Anna-Maria Monforte

1 reference

Europe PubMed Central

15 November 2017

Kjerstin H W Lanke

3

object named as

Kjerstin Lanke

1 reference

Europe PubMed Central

15 November 2017

author name string

Armando M De Palma

1

1 reference

Europe PubMed Central

15 November 2017

Bruno Coutard

4

1 reference

Europe PubMed Central

15 November 2017

Mirko Bergmann

5

1 reference

Europe PubMed Central

15 November 2017

Jacques Rohayem

11

1 reference

Europe PubMed Central

15 November 2017

language of work or name

0 references

publication date

12 March 2008

1 reference

Europe PubMed Central

15 November 2017

Journal of Virology

1 reference

Europe PubMed Central

15 November 2017

82

1 reference

Europe PubMed Central

15 November 2017

10

1 reference

Europe PubMed Central

15 November 2017

4720-4730

1 reference

Europe PubMed Central

15 November 2017

Molecular epidemiology of echoviruses 11 and 13, based on an environmental surveillance conducted in Toyama Prefecture, 2002-2003

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2346740

25 May 2018

Rhinovirus chemotherapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2346740

25 May 2018

A proline-rich region in the coxsackievirus 3A protein is required for the protein to inhibit endoplasmic reticulum-to-golgi transport

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2346740

25 May 2018

Atomic snapshots of an RNA packaging motor reveal conformational changes linking ATP hydrolysis to RNA translocation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2346740

25 May 2018

Structure of adeno-associated virus type 2 Rep40-ADP complex: insight into nucleotide recognition and catalysis by superfamily 3 helicases

1 reference

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25 May 2018

Regulation of poliovirus 3C protease by the 2C polypeptide

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2346740

25 May 2018

Regulation of picornavirus gene expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2346740

25 May 2018

Evolutionary history and higher order classification of AAA+ ATPases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2346740

25 May 2018

The interferon inducer ampligen [poly(I)-poly(C12U)] markedly protects mice against coxsackie B3 virus-induced myocarditis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2346740

25 May 2018

Spectrum and characteristics of the virus inhibitory action of 2-(alpha-hydroxybenzyl)-benzimidazole

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2346740

25 May 2018

Structure of the replicative helicase of the oncoprotein SV40 large tumour antigen

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2346740

25 May 2018

Biochemical and genetic studies of the VPg uridylylation reaction catalyzed by the RNA polymerase of poliovirus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2346740

25 May 2018

Outbreak of aseptic meningitis associated with echovirus 13.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2346740

25 May 2018

Treatment of picornavirus infections

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2346740

25 May 2018

Picornavirus IRESes and the poly(A) tail jointly promote cap-independent translation in a mammalian cell-free system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2346740

25 May 2018

The antiviral compound 5-(3,4-dichlorophenyl) methylhydantoin inhibits the post-synthetic cleavages and the assembly of poliovirus in a cell-free system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2346740

25 May 2018

Echovirus-9 protein 2C binds single-stranded RNA unspecifically

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2346740

25 May 2018

Remodeling the endoplasmic reticulum by poliovirus infection and by individual viral proteins: an autophagy-like origin for virus-induced vesicles

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2346740

25 May 2018

Formation of the poliovirus replication complex requires coupled viral translation, vesicle production, and viral RNA synthesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2346740

25 May 2018

Mutations in the 2C region of poliovirus responsible for altered sensitivity to benzimidazole derivatives

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2346740

25 May 2018

The picornavirus replication inhibitors HBB and guanidine in the echovirus-9 system: the significance of viral protein 2C

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2346740

25 May 2018

A cysteine-rich motif in poliovirus protein 2C(ATPase) is involved in RNA replication and binds zinc in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2346740

25 May 2018

Dependence of echovirus 9 on the enterovirus RNA replication inhibitor 2-(alpha-Hydroxybenzyl)-benzimidazole maps to nonstructural protein 2C

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2346740

25 May 2018

Synthesis and biological activity of novel 1H,3H-thiazolo[3,4-a]benzimidazoles: non-nucleoside human immunodeficiency virus type 1 reverse transcriptase inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2346740

25 May 2018

Characterization of the nucleoside triphosphatase activity of poliovirus protein 2C reveals a mechanism by which guanidine inhibits poliovirus replication

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2346740

25 May 2018

Amino-terminal region of poliovirus 2C protein is sufficient for membrane binding.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2346740

25 May 2018

Poliovirus-encoded 2C polypeptide specifically binds to the 3'-terminal sequences of viral negative-strand RNA

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2346740

25 May 2018

Poliovirus 2C protein determinants of membrane binding and rearrangements in mammalian cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2346740

25 May 2018

Crystal structure of the delta' subunit of the clamp-loader complex of E. coli DNA polymerase III

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2346740

25 May 2018

Poliovirus 2C region functions during encapsidation of viral RNA.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2346740

25 May 2018

Synchronous replication of poliovirus RNA: initiation of negative-strand RNA synthesis requires the guanidine-inhibited activity of protein 2C.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2346740

25 May 2018

Poliovirus protein 2C has ATPase and GTPase activities

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2346740

25 May 2018

Genetics of poliovirus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2346740

25 May 2018

Biochemical studies on poliovirus polypeptide 2C: evidence for ATPase activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2346740

25 May 2018

Induction of membrane proliferation by poliovirus proteins 2C and 2BC.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2346740

25 May 2018

Poliovirus protein 2C contains two regions involved in RNA binding activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2346740

25 May 2018

Distantly related sequences in the alpha- and beta-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2346740

25 May 2018

Action of guanidine on the replication of poliovirus RNA.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2346740

25 May 2018

Guanidine-dependent mutants of poliovirus: identification of three classes with different growth requirements

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2346740

25 May 2018

Production of guanidine-resistant and -dependent poliovirus mutants from cloned cDNA: mutations in polypeptide 2C are directly responsible for altered guanidine sensitivity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2346740

25 May 2018

Guanidine-selected mutants of poliovirus: mapping of point mutations to polypeptide 2C

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2346740

25 May 2018

Association of polioviral proteins of the P2 genomic region with the viral replication complex and virus-induced membrane synthesis as visualized by electron microscopic immunocytochemistry and autoradiography

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2346740

25 May 2018

Viral proteins containing the purine NTP-binding sequence pattern

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2346740

25 May 2018

Guanidine-resistant mutants of poliovirus have distinct mutations in peptide 2C.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2346740

25 May 2018

Structural organization of poliovirus RNA replication is mediated by viral proteins of the P2 genomic region

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2346740

25 May 2018

An intragenic revertant of a poliovirus 2C mutant has an uncoating defect

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2346740

25 May 2018

Analysis of the functional significance of amino acid residues in the putative NTP-binding pattern of the poliovirus 2C protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2346740

25 May 2018

Structural and functional characterization of the poliovirus replication complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2346740

25 May 2018

Successful treatment of enterovirus-infected mice by 2-(alpha-hydroxybenzyl)-benzimidazole and guanidine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2346740

25 May 2018

Recombinant protein expression and solubility screening in Escherichia coli: a comparative study.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2346740

15 August 2018

ATP hydrolysis and AMP kinase activities of nonstructural protein 2C of human parechovirus 1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2346740

15 August 2018

Multimerization reactions of coxsackievirus proteins 2B, 2C and 2BC: a mammalian two-hybrid analysis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2346740

15 August 2018

Interaction of picornavirus 2C polypeptide with the viral negative-strand RNA.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2346740

15 August 2018

Echovirus 7 associated encephalomyelitis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2346740

15 August 2018

Induction of intracellular membrane rearrangements by HAV proteins 2C and 2BC.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2346740

15 August 2018

Genetic studies on the poliovirus 2C protein, an NTPase. A plausible mechanism of guanidine effect on the 2C function and evidence for the importance of 2C oligomerization.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2346740

15 August 2018

Anti-enterovirus activity and structure–activity relationship of a series of 2,6-dihalophenyl-substituted 1H,3H-thiazolo[3,4-a]benzimidazoles

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2346740

1 December 2018

A conserved NTP-motif in putative helicases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2346740

1 December 2018

Studies of a putative amphipathic helix in the N-terminus of poliovirus protein 2C

1 reference

https://pubmed.ncbi.nlm.nih.gov/18337578

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Membrane rearrangement and vesicle induction by recombinant poliovirus 2C and 2BC in human cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/18337578

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amino terminal regions of poliovirus 2C protein mediate membrane binding

1 reference

https://pubmed.ncbi.nlm.nih.gov/18337578

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Echovirus 9 strain barty non-structural protein 2C has NTPase activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/18337578

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A new superfamily of putative NTP-binding domains encoded by genomes of small DNA and RNA viruses

1 reference

https://pubmed.ncbi.nlm.nih.gov/18337578

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Studies of the inhibitory action of guanidine on poliovirus multiplication in cell cultures

1 reference

https://pubmed.ncbi.nlm.nih.gov/18337578

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antiviral effect of guanidine

1 reference

https://pubmed.ncbi.nlm.nih.gov/18337578

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vitro Inhibition of Infectivity of Polio Viruses by Guanidine

1 reference

https://pubmed.ncbi.nlm.nih.gov/18337578

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synergistic Effect of 2-(α-Hydroxybenzyl)- benzimidazole and Guanidine on Picornavirus Reproduction

1 reference

https://pubmed.ncbi.nlm.nih.gov/18337578

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interaction of poliovirus-encoded 2C/2BC polypeptides with the 3' terminus negative-strand cloverleaf requires an intact stem-loop b

1 reference

https://pubmed.ncbi.nlm.nih.gov/18337578

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1128/JVI.01338-07

1 reference

Europe PubMed Central

15 November 2017

1 reference

Europe PubMed Central

15 November 2017

1 reference

Europe PubMed Central

15 November 2017

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