(Q43186594)

15 November 2017

Pyrimidinone nicotinamide mimetics as selective tankyrase and wnt pathway inhibitors suitable for in vivo pharmacology (English)

1 reference

15 November 2017

1 reference

1 reference

Jeffrey W Johannes

1

1 reference

15 November 2017

Lynsie Almeida

2

1 reference

15 November 2017

Bernard Barlaam

3

1 reference

15 November 2017

P Ann Boriack-Sjodin

4

1 reference

15 November 2017

Robert Casella

5

1 reference

15 November 2017

Rosemary A Croft

6

1 reference

15 November 2017

Allan P Dishington

7

1 reference

15 November 2017

Lakshmaiah Gingipalli

8

1 reference

15 November 2017

Chungang Gu

9

1 reference

15 November 2017

Janet L Hawkins

10

1 reference

15 November 2017

Jane L Holmes

11

1 reference

15 November 2017

Tina Howard

12

1 reference

15 November 2017

Jian Huang

13

1 reference

15 November 2017

Stephanos Ioannidis

14

1 reference

15 November 2017

Steven Kazmirski

15

1 reference

15 November 2017

Michelle L Lamb

16

1 reference

15 November 2017

Thomas M McGuire

17

1 reference

15 November 2017

Jane E Moore

18

1 reference

15 November 2017

Derek Ogg

19

1 reference

15 November 2017

Anil Patel

20

1 reference

15 November 2017

Kurt G Pike

21

1 reference

15 November 2017

Timothy Pontz

22

1 reference

15 November 2017

Graeme R Robb

23

1 reference

15 November 2017

Nancy Su

24

1 reference

15 November 2017

Haiyun Wang

25

1 reference

15 November 2017

Xiaoyun Wu

26

1 reference

15 November 2017

Hai-Jun Zhang

27

1 reference

15 November 2017

Yue Zhang

28

1 reference

15 November 2017

Xiaolan Zheng

29

1 reference

15 November 2017

Tao Wang

30

1 reference

15 November 2017

13 January 2015

1 reference

ACS Medicinal Chemistry Letters

15 November 2017

1 reference

15 November 2017

6

1 reference

15 November 2017

3

1 reference

15 November 2017

254-259

1 reference

Can we safely target the WNT pathway?

15 November 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4360163

Tankyrases: structure, function and therapeutic implications in cancer

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4360163

Design and Discovery of 2-Arylquinazolin-4-ones as Potent and Selective Inhibitors of Tankyrases

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4360163

Design, Synthesis, Crystallographic Studies, and Preliminary Biological Appraisal of New Substituted Triazolo[4,3- b ]pyridazin-8-amine Derivatives as Tankyrase Inhibitors

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4360163

para-Substituted 2-phenyl-3,4-dihydroquinazolin-4-ones as potent and selective tankyrase inhibitors

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4360163

Tankyrases as drug targets

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4360163

A novel tankyrase small-molecule inhibitor suppresses APC mutation-driven colorectal tumor growth.

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4360163

WNT signalling pathways as therapeutic targets in cancer

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4360163

PARP6, a mono(ADP-ribosyl) transferase and a negative regulator of cell proliferation, is involved in colorectal cancer development

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4360163

Wnt/beta-catenin signaling and small molecule inhibitors

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4360163

PARP inhibition: PARP1 and beyond

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4360163

Molecular origins of cancer: Molecular basis of colorectal cancer

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4360163

Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4360163

Zinc binding catalytic domain of human tankyrase 1

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4360163

Colorectal cancer and genetic alterations in the Wnt pathway

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4360163

Wnt/beta-catenin signaling in development and disease

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4360163

Tankyrase-1 polymerization of poly(ADP-ribose) is required for spindle structure and function

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4360163

Canonical Wnt signals are essential for homeostasis of the intestinal epithelium

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4360163

Tankyrase, a poly(ADP-ribose) polymerase at human telomeres

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4360163

Escape from flatland: increasing saturation as an approach to improving clinical success.

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4360163

15 August 2018

Identifiers

DOI

10.1021/ML5003663

1 reference

15 November 2017

1 reference

15 November 2017

1 reference