(Q43202086)

English

Targeting the angiopoietin (Ang)/Tie-2 pathway in the crosstalk between acute myeloid leukaemia and endothelial cells: studies of Tie-2 blocking antibodies, exogenous Ang-2 and inhibition of constitutive agonistic Ang-1 release.

scientific article published in February 2010

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20050812%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

Targeting the angiopoietin (Ang)/Tie-2 pathway in the crosstalk between acute myeloid leukaemia and endothelial cells: studies of Tie-2 blocking antibodies, exogenous Ang-2 and inhibition of constitutive agonistic Ang-1 release (English)

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20050812%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

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Philippe Lassalle

3

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20050812%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

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Håkon Reikvam

1

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16 January 2020

Kimberley Joanne Hatfield

2

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16 January 2020

Astrid Olsnes Kittang

4

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16 January 2020

Elisabeth Ersvaer

5

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16 January 2020

Øystein Bruserud

6

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16 January 2020

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1 February 2010

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16 January 2020

Expert Opinion on Investigational Drugs

1 reference

Europe PubMed Central

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16 January 2020

19

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16 January 2020

2

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16 January 2020

169-183

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20050812%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

Acute myeloid leukaemia

1 reference

https://api.crossref.org/works/10.1517%2F13543780903485659

21 January 2018

Prognostically useful gene-expression profiles in acute myeloid leukemia.

1 reference

https://api.crossref.org/works/10.1517%2F13543780903485659

21 January 2018

Acute myelogenous leukemia in elderly patients not eligible for intensive chemotherapy: the dark side of the moon

1 reference

https://api.crossref.org/works/10.1517%2F13543780903485659

21 January 2018

Clinically useful prognostic factors in acute myeloid leukemia

1 reference

https://api.crossref.org/works/10.1517%2F13543780903485659

21 January 2018

Antiangiogenic therapy in acute myelogenous leukemia: targeting of vascular endothelial growth factor and interleukin 8 as possible antileukemic strategies

1 reference

https://api.crossref.org/works/10.1517%2F13543780903485659

21 January 2018

Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning

1 reference

https://api.crossref.org/works/10.1517%2F13543780903485659

21 January 2018

Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis

1 reference

https://api.crossref.org/works/10.1517%2F13543780903485659

21 January 2018

Tie receptors and their angiopoietin ligands are context-dependent regulators of vascular remodeling

1 reference

https://api.crossref.org/works/10.1517%2F13543780903485659

21 January 2018

Angiopoietin: a TIE(d) balance in tumor angiogenesis.

1 reference

https://api.crossref.org/works/10.1517%2F13543780903485659

21 January 2018

Angiogenesis inhibitors in the treatment of cancer

1 reference

https://api.crossref.org/works/10.1517%2F13543780903485659

21 January 2018

Suppression of angiogenesis and tumor growth by selective inhibition of angiopoietin-2

1 reference

https://api.crossref.org/works/10.1517%2F13543780903485659

21 January 2018

Safety, pharmacokinetics, and antitumor activity of AMG 386, a selective angiopoietin inhibitor, in adult patients with advanced solid tumors

1 reference

https://api.crossref.org/works/10.1517%2F13543780903485659

21 January 2018

Phenotypic knockout of VEGF-R2 and Tie-2 with an intradiabody reduces tumor growth and angiogenesis in vivo

1 reference

https://api.crossref.org/works/10.1517%2F13543780903485659

21 January 2018

In vitro culture of human osteosarcoma cell lines: a comparison of functional characteristics for cell lines cultured in medium without and with fetal calf serum.

1 reference

https://api.crossref.org/works/10.1517%2F13543780903485659

21 January 2018

PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1517%2F13543780903485659

21 January 2018

The Jun N-terminal kinase inhibitor SP600125 is a ligand and antagonist of the aryl hydrocarbon receptor

1 reference

https://api.crossref.org/works/10.1517%2F13543780903485659

21 January 2018

Induction of apoptosis by SB202190 through inhibition of p38beta mitogen-activated protein kinase

1 reference

https://api.crossref.org/works/10.1517%2F13543780903485659

21 January 2018

Epigenetic targeting in acute myeloid leukemia: use of flow cytometry in monitoring therapeutic effects

1 reference

https://api.crossref.org/works/10.1517%2F13543780903485659

21 January 2018

Characterization of the secreted form of endothelial-cell-specific molecule 1 by specific monoclonal antibodies.

1 reference

https://api.crossref.org/works/10.1517%2F13543780903485659

21 January 2018

The proteasome inhibitors bortezomib and PR-171 have antiproliferative and proapoptotic effects on primary human acute myeloid leukaemia cells

1 reference

https://api.crossref.org/works/10.1517%2F13543780903485659

21 January 2018

Primary human acute myeloid leukaemia cells increase the proliferation of microvascular endothelial cells through the release of soluble mediators.

1 reference

https://api.crossref.org/works/10.1517%2F13543780903485659

21 January 2018

Subclassification of patients with acute myelogenous leukemia based on chemokine responsiveness and constitutive chemokine release by their leukemic cells

1 reference

https://api.crossref.org/works/10.1517%2F13543780903485659

21 January 2018

The protein kinase C agonist PEP005 increases NF-kappaB expression, induces differentiation and increases constitutive chemokine release by primary acute myeloid leukaemia cells

1 reference

https://api.crossref.org/works/10.1517%2F13543780903485659

21 January 2018

Inhibition of Tie-2 signaling induces endothelial cell apoptosis, decreases Akt signaling, and induces endothelial cell expression of the endogenous anti-angiogenic molecule, thrombospondin-1.

1 reference

https://api.crossref.org/works/10.1517%2F13543780903485659

21 January 2018

Angiopoietins 3 and 4: diverging gene counterparts in mice and humans

1 reference

https://api.crossref.org/works/10.1517%2F13543780903485659

21 January 2018

Multiple angiopoietin recombinant proteins activate the Tie1 receptor tyrosine kinase and promote its interaction with Tie2

1 reference

https://api.crossref.org/works/10.1517%2F13543780903485659

21 January 2018

Angiopoietin-2 is required for postnatal angiogenesis and lymphatic patterning, and only the latter role is rescued by Angiopoietin-1.

1 reference

https://api.crossref.org/works/10.1517%2F13543780903485659

21 January 2018

Biological action of angiopoietin-2 in a fibrin matrix model of angiogenesis is associated with activation of Tie2.

1 reference

https://api.crossref.org/works/10.1517%2F13543780903485659

21 January 2018

Vessel cooption, regression, and growth in tumors mediated by angiopoietins and VEGF.

1 reference

https://api.crossref.org/works/10.1517%2F13543780903485659

21 January 2018

Cell type-specific expression of angiopoietin-1 and angiopoietin-2 suggests a role in glioblastoma angiogenesis

1 reference

https://api.crossref.org/works/10.1517%2F13543780903485659

21 January 2018

In situ expression of angiopoietins in astrocytomas identifies angiopoietin-2 as an early marker of tumor angiogenesis

1 reference

https://api.crossref.org/works/10.1517%2F13543780903485659

21 January 2018

Dysmorphogenesis of kidney cortical peritubular capillaries in angiopoietin-2-deficient mice

1 reference

https://api.crossref.org/works/10.1517%2F13543780903485659

21 January 2018

New strategies in the treatment of acute myelogenous leukemia (AML): in vitro culture of aml cells--the present use in experimental studies and the possible importance for future therapeutic approaches.

1 reference

https://api.crossref.org/works/10.1517%2F13543780903485659

21 January 2018

The human hepatocyte growth factor (HGF) gene is transcriptionally activated by leukemia inhibitory factor through the Stat binding element

1 reference

https://api.crossref.org/works/10.1517%2F13543780903485659

21 January 2018

PEP005, a selective small-molecule activator of protein kinase C, has potent antileukemic activity mediated via the delta isoform of PKC.

1 reference

https://api.crossref.org/works/10.1517%2F13543780903485659

21 January 2018

MMP-12 induces IL-8/CXCL8 secretion through EGFR and ERK1/2 activation in epithelial cells

1 reference

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21 January 2018

Identifiers

10.1517/13543780903485659

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20050812%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20050812%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

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