(Q46450279)

English

PEP005, a selective small-molecule activator of protein kinase C, has potent antileukemic activity mediated via the delta isoform of PKC.

scientific article published on 21 April 2005

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scholarly article

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15845901%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

PEP005, a selective small-molecule activator of protein kinase C, has potent antileukemic activity mediated via the delta isoform of PKC (English)

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15845901%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

Euphorbia peplus

1 reference

Ingenol-3-angelate

1 reference

7

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11 January 2020

8

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11 January 2020

author name string

Peter Hampson

1

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11 January 2020

Hema Chahal

2

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11 January 2020

Farhat Khanim

3

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11 January 2020

Rachel Hayden

4

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11 January 2020

Anneke Mulder

5

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11 January 2020

Lakhvir Kaur Assi

6

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11 January 2020

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publication date

21 April 2005

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11 January 2020

number of pages

7

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11 January 2020

106

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11 January 2020

4

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11 January 2020

1362-1368

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11 January 2020

Characterization of the interaction of ingenol 3-angelate with protein kinase C.

2 references

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PKC-δ is an apoptotic lamin kinase

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Rottlerin, a novel protein kinase inhibitor

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PKCdelta acts as a growth and tumor suppressor in rat colonic epithelial cells

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Variant cell lines from the human promyelocyte line HL60.

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Antitumor activity of 3-ingenyl angelate: plasma membrane and mitochondrial disruption and necrotic cell death

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Effect of intravenous infusions of 12-O-tetradecanoylphorbol-13-acetate (TPA) in patients with myelocytic leukemia: preliminary studies on therapeutic efficacy and toxicity

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Inactivation of DNA-dependent protein kinase by protein kinase Cdelta: implications for apoptosis

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Proteolytic activation of protein kinase C delta by an ICE/CED 3-like protease induces characteristics of apoptosis

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Rapid quantitation of apoptosis in pure and heterogeneous cell populations using flow cytometry

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Regulation of monocyte apoptosis by the protein kinase Cdelta-dependent phosphorylation of caspase-3.

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HOME TREATMENT OF SKIN CANCER AND SOLAR KERATOSES

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PKC alpha mediates chemoresistance in acute lymphoblastic leukemia through effects on Bcl2 phosphorylation

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