(Q43251117)

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Up-regulating sphingosine 1-phosphate receptor-2 signaling impairs chemotactic, wound-healing, and morphogenetic responses in senescent endothelial cells.

scientific article published on 2 September 2008

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scholarly article

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18765664%20AND%20SRC:MED&resulttype=core&format=json

13 January 2020

Up-regulating sphingosine 1-phosphate receptor-2 signaling impairs chemotactic, wound-healing, and morphogenetic responses in senescent endothelial cells (English)

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13 January 2020

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11

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13 January 2020

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13 January 2020

Christopher D. Kontos

9

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13 January 2020

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Rosendo Estrada

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13 January 2020

Qun Zeng

2

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13 January 2020

Hongwei Lu

3

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13 January 2020

Harshini Sarojini

4

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13 January 2020

Jen-Fu Lee

5

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13 January 2020

Teresa Sanchez

7

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13 January 2020

Eugenia Wang

8

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13 January 2020

Chen-Yong Lin

10

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13 January 2020

Bodduluri Haribabu

12

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13 January 2020

Menq-Jer Lee

13

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13 January 2020

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2 September 2008

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13 January 2020

Journal of Biological Chemistry

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13 January 2020

283

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13 January 2020

44

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13 January 2020

30363-30375

1 reference

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13 January 2020

Rho GTPases mediated integrin alpha v beta 3 activation in sphingosine-1-phosphate stimulated chemotaxis of endothelial cells

1 reference

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25 May 2018

Principles of bioactive lipid signalling: lessons from sphingolipids

1 reference

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25 May 2018

Ceramide transfer protein function is essential for normal oxidative stress response and lifespan

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2573088

25 May 2018

Endothelial cell senescence.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2573088

25 May 2018

Age-related changes in neutral sphingomyelin-specific phospholipase C activity in striatum, hippocampus, and frontal cortex: implication for sensitivity to stress and inflammation

1 reference

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25 May 2018

Cellular senescence in vivo: its relevance in ageing and cardiovascular disease.

1 reference

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25 May 2018

CDK2 translational down-regulation during endothelial senescence

1 reference

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25 May 2018

The S1P2 receptor negatively regulates platelet-derived growth factor-induced motility and proliferation.

1 reference

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25 May 2018

The G protein-coupled receptor S1P2 regulates Rho/Rho kinase pathway to inhibit tumor cell migration

1 reference

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25 May 2018

PTEN as an effector in the signaling of antimigratory G protein-coupled receptor

1 reference

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25 May 2018

Sphingosine 1-phosphate inhibits migration of RBL-2H3 cells via S1P2: cross-talk between platelets and mast cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2573088

25 May 2018

Vascular cell senescence and vascular aging

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2573088

25 May 2018

Electrical wound-healing assay for cells in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2573088

25 May 2018

Role of leukotriene B4 receptors in the development of atherosclerosis: potential mechanisms

1 reference

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25 May 2018

Inhibitory and stimulatory regulation of Rac and cell motility by the G12/13-Rho and Gi pathways integrated downstream of a single G protein-coupled sphingosine-1-phosphate receptor isoform

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2573088

25 May 2018

Constitutive activation of rac1 results in mitochondrial oxidative stress and induces premature endothelial cell senescence.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2573088

25 May 2018

Protective role of endothelial nitric oxide synthase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2573088

25 May 2018

International Union of Pharmacology. XXXIV. Lysophospholipid receptor nomenclature

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2573088

25 May 2018

Endothelial cell senescence in human atherosclerosis: role of telomere in endothelial dysfunction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2573088

25 May 2018

Cellular senescence as a tumor-suppressor mechanism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2573088

25 May 2018

Cellular senescence, cancer and aging: the telomere connection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2573088

25 May 2018

Akt-mediated phosphorylation of the G protein-coupled receptor EDG-1 is required for endothelial cell chemotaxis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2573088

25 May 2018

Role of ceramide in mediating the inhibition of telomerase activity in A549 human lung adenocarcinoma cells

1 reference

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25 May 2018

Characterization of a novel sphingosine 1-phosphate receptor, Edg-8

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2573088

25 May 2018

Ceramide induces expression of the senescence histochemical marker, beta-galactosidase, in human fibroblasts.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2573088

25 May 2018

Bioactive lysophospholipids and their G protein-coupled receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2573088

25 May 2018

Vascular endothelial cell adherens junction assembly and morphogenesis induced by sphingosine-1-phosphate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2573088

25 May 2018

Differential coupling of the sphingosine 1-phosphate receptors Edg-1, Edg-3, and H218/Edg-5 to the G(i), G(q), and G(12) families of heterotrimeric G proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2573088

25 May 2018

Sphingosine-1-phosphate: extracellular mediator or intracellular second messenger?

1 reference

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25 May 2018

Differential pharmacological properties and signal transduction of the sphingosine 1-phosphate receptors EDG-1, EDG-3, and EDG-5

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2573088

25 May 2018

Sphingosine 1-phosphate: a prototype of a new class of second messengers.

1 reference

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25 May 2018

Signaling mechanisms and molecular characteristics of G protein-coupled receptors for lysophosphatidic acid and sphingosine 1-phosphate

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Age-dependent impairment of angiogenesis

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25 May 2018

Sphingosine-1-phosphate as a ligand for the G protein-coupled receptor EDG-1

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25 May 2018

Sphingosine 1-phosphate signalling through the G-protein-coupled receptor Edg-1.

1 reference

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25 May 2018

Role of ceramide in cellular senescence

1 reference

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25 May 2018

Role for ceramide in cell cycle arrest.

1 reference

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Reduction of nitric oxide producing activity associated with in vitro aging in cultured human umbilical vein endothelial cell

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A biomarker that identifies senescent human cells in culture and in aging skin in vivo

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A simple, quantitative method for assessing angiogenesis and antiangiogenic agents using reconstituted basement membrane, heparin, and fibroblast growth factor

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Increased expression of extracellular proteins as a hallmark of human endothelial cell in vitro senescence.

1 reference

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Shift in sphingolipid metabolism leads to an accumulation of ceramide in senescence

1 reference

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High-density lipoprotein inhibits migration of vascular smooth muscle cells through its sphingosine 1-phosphate component

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15 August 2018

Sphingosine-1-phosphate, a platelet-derived lysophospholipid mediator, negatively regulates cellular Rac activity and cell migration in vascular smooth muscle cells

1 reference

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Human lens phospholipid changes with age and cataract

1 reference

https://pubmed.ncbi.nlm.nih.gov/18765664

12 December 2020

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inferred from PubMed ID database lookup

Dual roles of tight junction-associated protein, zonula occludens-1, in sphingosine 1-phosphate-mediated endothelial chemotaxis and barrier integrity

1 reference

https://pubmed.ncbi.nlm.nih.gov/18765664

12 December 2020

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inferred from PubMed ID database lookup

PTEN modulates vascular endothelial growth factor-mediated signaling and angiogenic effects

1 reference

https://pubmed.ncbi.nlm.nih.gov/18765664

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Extension of the life-span of human endothelial cells by an interleukin-1 alpha antisense oligomer

1 reference

https://pubmed.ncbi.nlm.nih.gov/18765664

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sphingosine 1-phosphate is a blood constituent released from activated platelets, possibly playing a variety of physiological and pathophysiological roles

1 reference

https://pubmed.ncbi.nlm.nih.gov/18765664

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M804392200

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18765664%20AND%20SRC:MED&resulttype=core&format=json

13 January 2020

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18765664%20AND%20SRC:MED&resulttype=core&format=json

13 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18765664%20AND%20SRC:MED&resulttype=core&format=json

13 January 2020

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