(Q43257601)

English

Preclinical assessment of the absorption, distribution, metabolism and excretion of GDC-0449 (2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(methylsulfonyl)benzamide), an orally bioavailable systemic Hedgehog signalling pathway inhibitor.

scientific article published in November 2009

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scholarly article

1 reference

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19845436%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

Preclinical assessment of the absorption, distribution, metabolism and excretion of GDC-0449 (2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(methylsulfonyl)benzamide), an orally bioavailable systemic Hedgehog signalling pathway inhibitor (English)

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19845436%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

11

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10 February 2020

author name string

H Wong

1

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10 February 2020

J Z Chen

2

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10 February 2020

B Chou

3

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10 February 2020

J S Halladay

4

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10 February 2020

J R Kenny

5

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10 February 2020

H La

6

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10 February 2020

J C Marsters

7

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10 February 2020

E Plise

8

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10 February 2020

P J Rudewicz

9

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10 February 2020

K Robarge

10

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10 February 2020

S Wong

12

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10 February 2020

C Zhang

13

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10 February 2020

S C Khojasteh

14

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10 February 2020

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publication date

1 November 2009

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10 February 2020

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10 February 2020

39

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10 February 2020

11

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10 February 2020

850-861

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10 February 2020

Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours

1 reference

https://api.crossref.org/works/10.3109%2F00498250903180289

21 January 2018

The Hedgehog signaling pathway as a target for anticancer drug discovery

1 reference

https://api.crossref.org/works/10.3109%2F00498250903180289

21 January 2018

Interspecies pharmacokinetic scaling and the evolutionary-comparative paradigm

1 reference

https://api.crossref.org/works/10.3109%2F00498250903180289

21 January 2018

An orally bioavailable small-molecule inhibitor of Hedgehog signaling inhibits tumor initiation and metastasis in pancreatic cancer.

1 reference

https://api.crossref.org/works/10.3109%2F00498250903180289

21 January 2018

Hedgehog signalling in prostate regeneration, neoplasia and metastasis

1 reference

https://api.crossref.org/works/10.3109%2F00498250903180289

21 January 2018

Targeted inhibition of hedgehog signaling by cyclopamine prodrugs for advanced prostate cancer

1 reference

https://api.crossref.org/works/10.3109%2F00498250903180289

21 January 2018

Dose- and route-dependent teratogenicity, toxicity, and pharmacokinetic profiles of the hedgehog signaling antagonist cyclopamine in the mouse.

1 reference

https://api.crossref.org/works/10.3109%2F00498250903180289

21 January 2018

Hedgehog signalling in cancer formation and maintenance

1 reference

https://api.crossref.org/works/10.3109%2F00498250903180289

21 January 2018

Targeting medulloblastoma: small-molecule inhibitors of the Sonic Hedgehog pathway as potential cancer therapeutics

1 reference

https://api.crossref.org/works/10.3109%2F00498250903180289

21 January 2018

Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis

1 reference

https://api.crossref.org/works/10.3109%2F00498250903180289

21 January 2018

Semisynthetic cyclopamine analogues as potent and orally bioavailable hedgehog pathway antagonists

1 reference

https://api.crossref.org/works/10.3109%2F00498250903180289

21 January 2018

Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer

1 reference

https://api.crossref.org/works/10.3109%2F00498250903180289

21 January 2018

Hedgehog pathway inhibitor HhAntag691 is a potent inhibitor of ABCG2/BCRP and ABCB1/Pgp

1 reference

https://api.crossref.org/works/10.3109%2F00498250903180289

21 January 2018

Identifiers

10.3109/00498250903180289

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19845436%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19845436%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

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