(Q43285195)

English

Mixed-lineage-leukemia (MLL) fusion protein collaborates with Ras to induce acute leukemia through aberrant Hox expression and Raf activation

scientific article published on 27 August 2009

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

18 November 2017

Mixed-lineage-leukemia (MLL) fusion protein collaborates with Ras to induce acute leukemia through aberrant Hox expression and Raf activation (English)

1 reference

Europe PubMed Central

PubMed publication ID

18 November 2017

1 reference

based on heuristic

inferred from title

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author name string

R Ono

1

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Europe PubMed Central

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18 November 2017

H Kumagai

2

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18 November 2017

H Nakajima

3

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Europe PubMed Central

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18 November 2017

A Hishiya

4

1 reference

Europe PubMed Central

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18 November 2017

T Taki

5

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Europe PubMed Central

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18 November 2017

K Horikawa

6

1 reference

Europe PubMed Central

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18 November 2017

K Takatsu

7

1 reference

Europe PubMed Central

PubMed publication ID

18 November 2017

T Satoh

8

1 reference

Europe PubMed Central

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18 November 2017

Y Hayashi

9

1 reference

Europe PubMed Central

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18 November 2017

T Kitamura

10

1 reference

Europe PubMed Central

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18 November 2017

T Nosaka

11

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Europe PubMed Central

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18 November 2017

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27 August 2009

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Europe PubMed Central

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18 November 2017

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Europe PubMed Central

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18 November 2017

23

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18 November 2017

12

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18 November 2017

2197-2209

1 reference

Europe PubMed Central

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18 November 2017

Cancer genes and the pathways they control

1 reference

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Oncogenic transcription factors in the human acute leukemias

1 reference

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The critical role of chromosome translocations in human leukemias.

1 reference

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Focus on acute leukemias

1 reference

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PML/RARalpha and FLT3-ITD induce an APL-like disease in a mouse model

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2009.177

21 January 2018

The AML1-ETO fusion gene and the FLT3 length mutation collaborate in inducing acute leukemia in mice

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2009.177

21 January 2018

MLL-AF9 and FLT3 cooperation in acute myelogenous leukemia: development of a model for rapid therapeutic assessment.

1 reference

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AML1 mutations induced MDS and MDS/AML in a mouse BMT model

1 reference

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21 January 2018

Molecular mechanisms of leukemogenesis mediated by MLL fusion proteins

1 reference

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21 January 2018

New insights to the MLL recombinome of acute leukemias

1 reference

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21 January 2018

The menin tumor suppressor protein is an essential oncogenic cofactor for MLL-associated leukemogenesis

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2009.177

21 January 2018

Extending the repertoire of the mixed-lineage leukemia gene MLL in leukemogenesis

1 reference

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21 January 2018

MLL: a histone methyltransferase disrupted in leukemia

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2009.177

21 January 2018

An Mll-AF9 fusion gene made by homologous recombination causes acute leukemia in chimeric mice: a method to create fusion oncogenes

1 reference

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21 January 2018

Mll fusions generated by Cre-loxP-mediated de novo translocations can induce lineage reassignment in tumorigenesis

1 reference

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21 January 2018

Conditional MLL-CBP targets GMP and models therapy-related myeloproliferative disease.

1 reference

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21 January 2018

A murine Mll-AF4 knock-in model results in lymphoid and myeloid deregulation and hematologic malignancy

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2009.177

21 January 2018

FLT3 mutations in the activation loop of tyrosine kinase domain are frequently found in infant ALL with MLL rearrangements and pediatric ALL with hyperdiploidy

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2009.177

21 January 2018

K-Ras mutations and N-Ras mutations in childhood acute leukemias with or without mixed-lineage leukemia gene rearrangements.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2009.177

21 January 2018

The roles of FLT3 in hematopoiesis and leukemia

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2009.177

21 January 2018

MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2009.177

21 January 2018

Selective cytotoxic mechanism of GTP-14564, a novel tyrosine kinase inhibitor in leukemia cells expressing a constitutively active Fms-like tyrosine kinase 3 (FLT3).

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2009.177

21 January 2018

AML-associated Flt3 kinase domain mutations show signal transduction differences compared with Flt3 ITD mutations.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2009.177

21 January 2018

STAT5 as a molecular regulator of proliferation, differentiation and apoptosis in hematopoietic cells

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2009.177

21 January 2018

Hyperactive Ras in developmental disorders and cancer

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2009.177

21 January 2018

Constitutive activation of STAT5 by a point mutation in the SH2 domain

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2009.177

21 January 2018

Identification and characterization of a constitutively active STAT5 mutant that promotes cell proliferation

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2009.177

21 January 2018

Hoxa9 transforms primary bone marrow cells through specific collaboration with Meis1a but not Pbx1b

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2009.177

21 January 2018

Visualizing spatiotemporal dynamics of multicellular cell-cycle progression

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2009.177

21 January 2018

Hoxa9 immortalizes a granulocyte-macrophage colony-stimulating factor-dependent promyelocyte capable of biphenotypic differentiation to neutrophils or macrophages, independent of enforced meis expression

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2009.177

21 January 2018

Disruption of Sept6, a fusion partner gene of MLL, does not affect ontogeny, leukemogenesis induced by MLL-SEPT6, or phenotype induced by the loss of Sept4.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2009.177

21 January 2018

Deletion of the carboxyl-terminal transactivation domain of MGF-Stat5 results in sustained DNA binding and a dominant negative phenotype.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2009.177

21 January 2018

FLT3-ITD and tyrosine kinase domain mutants induce 2 distinct phenotypes in a murine bone marrow transplantation model

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2009.177

21 January 2018

Oncogenic NRAS rapidly and efficiently induces CMML- and AML-like diseases in mice

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2009.177

21 January 2018

JunB protects against myeloid malignancies by limiting hematopoietic stem cell proliferation and differentiation without affecting self-renewal.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2009.177

21 January 2018

Mutations of genes in the receptor tyrosine kinase (RTK)/RAS-BRAF signal transduction pathway in therapy-related myelodysplasia and acute myeloid leukemia

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2009.177

21 January 2018

Oncogenic K-ras cooperates with PML-RAR alpha to induce an acute promyelocytic leukemia-like disease.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2009.177

21 January 2018

RAS oncogene suppression induces apoptosis followed by more differentiated and less myelosuppressive disease upon relapse of acute myeloid leukemia

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2009.177

21 January 2018

Mouse models of human AML accurately predict chemotherapy response

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2009.177

21 January 2018

FLT3-activating mutations are associated with poor prognostic features in AML at diagnosis but they are not an independent prognostic factor.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2009.177

21 January 2018

Prognostic relevance of FLT3-TKD mutations in AML: the combination matters--an analysis of 3082 patients

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2009.177

21 January 2018

Hematopoietic, angiogenic and eye defects in Meis1 mutant animals

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2009.177

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Meis1 is an essential and rate-limiting regulator of MLL leukemia stem cell potential.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2009.177

21 January 2018

Continuous MLL-ENL expression is necessary to establish a "Hox Code" and maintain immortalization of hematopoietic progenitor cells

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2009.177

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Trib1 and Evi1 cooperate with Hoxa and Meis1 in myeloid leukemogenesis.

1 reference

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Retrovirus-mediated gene transfer and expression cloning: powerful tools in functional genomics

1 reference

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Defective lymphoid development in mice lacking Jak3

1 reference

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inferred from DOI database lookup

Stat5 is essential for the myelo- and lymphoproliferative disease induced by TEL/JAK2

1 reference

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Cooperative activation of Hoxa and Pbx1-related genes in murine myeloid leukaemias

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10.1038/LEU.2009.177

1 reference

Europe PubMed Central

PubMed publication ID

18 November 2017

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PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

18 November 2017

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