(Q43288339)

English

In silico structure-based design of a novel class of potent and selective small peptide inhibitor of Mycobacterium tuberculosis Dihydrofolate reductase, a potential target for anti-TB drug discovery

scientific article published on 21 August 2009

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

18 November 2017

In silico structure-based design of a novel class of potent and selective small peptide inhibitor of Mycobacterium tuberculosis Dihydrofolate reductase, a potential target for anti-TB drug discovery (English)

1 reference

Europe PubMed Central

PubMed publication ID

18 November 2017

Mycobacterium tuberculosis

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author name string

Manoj Kumar

1

1 reference

Europe PubMed Central

PubMed publication ID

18 November 2017

Rajakrishnan Vijayakrishnan

2

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Europe PubMed Central

PubMed publication ID

18 November 2017

Gita Subba Rao

3

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Europe PubMed Central

PubMed publication ID

18 November 2017

publication date

21 August 2009

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Europe PubMed Central

PubMed publication ID

18 November 2017

Molecular Diversity

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Europe PubMed Central

PubMed publication ID

18 November 2017

14

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Europe PubMed Central

PubMed publication ID

18 November 2017

3

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Europe PubMed Central

PubMed publication ID

18 November 2017

595-604

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Europe PubMed Central

PubMed publication ID

18 November 2017

Binding mode analysis of 2,4-diamino-5-methyl-5-deaza-6-substituted pteridines with Mycobacterium tuberculosis and human dihydrofolate reductases

1 reference

https://api.crossref.org/works/10.1007%2FS11030-009-9172-6

21 January 2018

Peptide-based drug design: here and now

1 reference

https://pubmed.ncbi.nlm.nih.gov/19697148

12 December 2020

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Dihydrofolate reductase as a therapeutic target

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https://pubmed.ncbi.nlm.nih.gov/19697148

12 December 2020

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The Protein Data Bank

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https://pubmed.ncbi.nlm.nih.gov/19697148

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XDR Tuberculosis — Implications for Global Public Health

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https://pubmed.ncbi.nlm.nih.gov/19697148

12 December 2020

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Three-dimensional structure of M. tuberculosis dihydrofolate reductase reveals opportunities for the design of novel tuberculosis drugs

1 reference

https://pubmed.ncbi.nlm.nih.gov/19697148

12 December 2020

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Plasmodium falciparum: kinetic interactions of WR99210 with pyrimethamine-sensitive and pyrimethamine-resistant dihydrofolate reductase

1 reference

https://pubmed.ncbi.nlm.nih.gov/19697148

12 December 2020

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The development of a simple empirical scoring function to estimate the binding constant for a protein-ligand complex of known three-dimensional structure

1 reference

https://pubmed.ncbi.nlm.nih.gov/19697148

12 December 2020

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Structure-based design of a novel class of potent inhibitors of InhA, the enoyl acyl carrier protein reductase from Mycobacterium tuberculosis: a computer modelling approach

1 reference

https://pubmed.ncbi.nlm.nih.gov/19697148

12 December 2020

based on heuristic

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Structure-based design of a new class of highly selective aminoimidazo[1,2-a]pyridine-based inhibitors of cyclin dependent kinases.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19697148

12 December 2020

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Comparison of two independent crystal structures of human dihydrofolate reductase ternary complexes reduced with nicotinamide adenine dinucleotide phosphate and the very tight-binding inhibitor PT523

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https://pubmed.ncbi.nlm.nih.gov/19697148

12 December 2020

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The growing burden of tuberculosis: global trends and interactions with the HIV epidemic

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https://pubmed.ncbi.nlm.nih.gov/19697148

12 December 2020

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Pyrimethamine analogs as strong inhibitors of double and quadruple mutants of dihydrofolate reductase in human malaria parasites

1 reference

https://pubmed.ncbi.nlm.nih.gov/19697148

12 December 2020

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On the use of LUDI to search the Fine Chemicals Directory for ligands of proteins of known three-dimensional structure

1 reference

https://pubmed.ncbi.nlm.nih.gov/19697148

12 December 2020

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Mycobacterium tuberculosis dihydrofolate reductase is a target for isoniazid

1 reference

https://pubmed.ncbi.nlm.nih.gov/19697148

12 December 2020

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Cloning, expression, and characterization of Mycobacterium tuberculosis dihydrofolate reductase

1 reference

https://pubmed.ncbi.nlm.nih.gov/19697148

12 December 2020

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Tuberculosis drug resistance: a global threat

1 reference

https://pubmed.ncbi.nlm.nih.gov/19697148

12 December 2020

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NMR solution structure of the antitumor compound PT523 and NADPH in the ternary complex with human dihydrofolate reductase

1 reference

https://pubmed.ncbi.nlm.nih.gov/19697148

12 December 2020

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Detailed analysis of grid-based molecular docking: A case study of CDOCKER-A CHARMm-based MD docking algorithm.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19697148

12 December 2020

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Current medical treatment for tuberculosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/19697148

12 December 2020

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Comparative evaluation of 11 scoring functions for molecular docking

1 reference

https://pubmed.ncbi.nlm.nih.gov/19697148

12 December 2020

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Efficacy of trimethoprim-sulphamethoxazole prophylaxis to decrease morbidity and mortality in HIV-1-infected patients with tuberculosis in Abidjan, Côte d'Ivoire: a randomised controlled trial

1 reference

https://pubmed.ncbi.nlm.nih.gov/19697148

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prediction of binding constants of protein ligands: a fast method for the prioritization of hits obtained from de novo design or 3D database search programs

1 reference

https://pubmed.ncbi.nlm.nih.gov/19697148

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S11030-009-9172-6

1 reference

Europe PubMed Central

PubMed publication ID

18 November 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

18 November 2017

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