(Q43452372)

23 November 2017

title

Yeast models for amyloid disease (English)

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23 November 2017

2

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23 November 2017

Barry Panaretou

1

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23 November 2017

publication date

1 January 2014

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23 November 2017

published in

Essays in Biochemistry

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23 November 2017

volume

56

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23 November 2017

page(s)

85-97

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Genetics of Parkinson's disease

23 November 2017

cites work

1 reference

https://api.crossref.org/works/10.1042%2FBSE0560085

Simple is good: yeast models of neurodegeneration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBSE0560085

Aggregate clearance of α-synuclein in Saccharomyces cerevisiae depends more on autophagosome and vacuole function than on the proteasome

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBSE0560085

SNCA (α-synuclein)-induced toxicity in yeast cells is dependent on sirtuin 2 (Sir2)-mediated mitophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBSE0560085

Yeast genes that enhance the toxicity of a mutant huntingtin fragment or alpha-synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBSE0560085

Phosphorylation, lipid raft interaction and traffic of alpha-synuclein in a yeast model for Parkinson

21 January 2018

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https://api.crossref.org/works/10.1042%2FBSE0560085

Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models

21 January 2018

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https://api.crossref.org/works/10.1042%2FBSE0560085

Compounds from an unbiased chemical screen reverse both ER-to-Golgi trafficking defects and mitochondrial dysfunction in Parkinson's disease models

21 January 2018

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https://api.crossref.org/works/10.1042%2FBSE0560085

A yeast-based model of alpha-synucleinopathy identifies compounds with therapeutic potential

21 January 2018

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https://api.crossref.org/works/10.1042%2FBSE0560085

Rapid selection of cyclic peptides that reduce alpha-synuclein toxicity in yeast and animal models

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBSE0560085

Alpha-synuclein targets the plasma membrane via the secretory pathway and induces toxicity in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBSE0560085

YGR198w (YPP1) targets A30P alpha-synuclein to the vacuole for degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBSE0560085

A genome-wide screen in yeast identifies specific oxidative stress genes required for the maintenance of sub-cellular redox homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBSE0560085

Starvation induced cell death in autophagy-defective yeast mutants is caused by mitochondria dysfunction

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBSE0560085

A yeast model for amyloid-β aggregation exemplifies the role of membrane trafficking and PICALM in cytotoxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBSE0560085

Functional links between Aβ toxicity, endocytic trafficking, and Alzheimer's disease risk factors in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBSE0560085

Modulation of Abeta42 low-n oligomerization using a novel yeast reporter system

21 January 2018

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https://api.crossref.org/works/10.1042%2FBSE0560085

Development of a novel yeast cell-based system for studying the aggregation of Alzheimer's disease-associated Abeta peptides in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBSE0560085

Development and validation of a yeast high-throughput screen for inhibitors of Aβ₄₂ oligomerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBSE0560085

Oligomers on the brain: the emerging role of soluble protein aggregates in neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBSE0560085

A yeast model of optineurin proteinopathy reveals a unique aggregation pattern associated with cellular toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBSE0560085

Inclusions in frontotemporal lobar degeneration with TDP-43 proteinopathy (FTLD-TDP) and amyotrophic lateral sclerosis (ALS), but not FTLD with FUS proteinopathy (FTLD-FUS), have properties of amyloid.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBSE0560085

Amyotrophic lateral sclerosis is a non-amyloid disease in which extensive misfolding of SOD1 is unique to the familial form

21 January 2018

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https://api.crossref.org/works/10.1042%2FBSE0560085

Prion-like propagation of mutant superoxide dismutase-1 misfolding in neuronal cells

21 January 2018

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https://api.crossref.org/works/10.1042%2FBSE0560085

A yeast TDP-43 proteinopathy model: Exploring the molecular determinants of TDP-43 aggregation and cellular toxicity

21 January 2018

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https://api.crossref.org/works/10.1042%2FBSE0560085

FUS/TLS forms cytoplasmic aggregates, inhibits cell growth and interacts with TDP-43 in a yeast model of amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBSE0560085

Inhibition of RNA lariat debranching enzyme suppresses TDP-43 toxicity in ALS disease models

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBSE0560085

Molecular determinants and genetic modifiers of aggregation and toxicity for the ALS disease protein FUS/TLS

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBSE0560085

Expression of human FUS/TLS in yeast leads to protein aggregation and cytotoxicity, recapitulating key features of FUS proteinopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBSE0560085

Aggregation of huntingtin in yeast varies with the length of the polyglutamine expansion and the expression of chaperone proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBSE0560085

A genomic screen in yeast implicates kynurenine 3-monooxygenase as a therapeutic target for Huntington disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBSE0560085

Targeting kynurenine 3-monooxygenase (KMO): implications for therapy in Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBSE0560085

The kynurenine pathway modulates neurodegeneration in a Drosophila model of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBSE0560085

Kynurenine 3-monooxygenase inhibition in blood ameliorates neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBSE0560085

Glutathione peroxidase activity is neuroprotective in models of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBSE0560085

Prions: protein aggregation and infectious diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBSE0560085

De novo generation of a PrPSc-like conformation in living cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBSE0560085

Probing the role of PrP repeats in conformational conversion and amyloid assembly of chimeric yeast prions

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBSE0560085

Prion protein repeat expansion results in increased aggregation and reveals phenotypic variability.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBSE0560085

Probing the role of structural features of mouse PrP in yeast by expression as Sup35-PrP fusions

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBSE0560085

Isolation of drugs active against mammalian prions using a yeast-based screening assay

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBSE0560085

Protein folding activity of ribosomal RNA is a selective target of two unrelated antiprion drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBSE0560085

The toll-like receptor agonist imiquimod is active against prions

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBSE0560085

The Parkinson's disease protein alpha-synuclein disrupts cellular Rab homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBSE0560085

21 January 2018

Identifiers

DOI

10.1042/BSE0560085

1 reference

23 November 2017

1 reference