(Q43509136)

English

Analysis of biological effects and signaling properties of Flt-1 (VEGFR-1) and KDR (VEGFR-2). A reassessment using novel receptor-specific vascular endothelial growth factor mutants

scientific article published on 31 October 2000

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scholarly article

1 reference

Europe PubMed Central

24 November 2017

Analysis of biological effects and signaling properties of Flt-1 (VEGFR-1) and KDR (VEGFR-2). A reassessment using novel receptor-specific vascular endothelial growth factor mutants (English)

1 reference

Europe PubMed Central

24 November 2017

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author name string

Gille H

1

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Europe PubMed Central

24 November 2017

Kowalski J

2

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Europe PubMed Central

24 November 2017

Li B

3

1 reference

Europe PubMed Central

24 November 2017

LeCouter J

4

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Europe PubMed Central

24 November 2017

Moffat B

5

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Europe PubMed Central

24 November 2017

Zioncheck TF

6

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Europe PubMed Central

24 November 2017

Pelletier N

7

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Europe PubMed Central

24 November 2017

Ferrara N

8

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Europe PubMed Central

24 November 2017

language of work or name

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publication date

31 October 2000

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Europe PubMed Central

24 November 2017

Journal of Biological Chemistry

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Europe PubMed Central

24 November 2017

276

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Europe PubMed Central

24 November 2017

3222-3230

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Europe PubMed Central

24 November 2017

5

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Europe PubMed Central

24 November 2017

Role of vascular endothelial growth factor in the regulation of angiogenesis

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Mechanisms of angiogenesis

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Clinical applications of angiogenic growth factors and their inhibitors

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The biology of vascular endothelial growth factor

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Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium

1 reference

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Flt-1 lacking the tyrosine kinase domain is sufficient for normal development and angiogenesis in mice

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Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice

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Isolation of a human placenta cDNA coding for a protein related to the vascular permeability factor

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Placenta growth factor stimulates MAP kinase and mitogenicity but not phospholipase C-gamma and migration of endothelial cells expressing Flt 1

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A novel vascular endothelial growth factor encoded by Orf virus, VEGF-E, mediates angiogenesis via signalling through VEGFR-2 (KDR) but not VEGFR-1 (Flt-1) receptor tyrosine kinases

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Nitric oxide production contributes to the angiogenic properties of vascular endothelial growth factor in human endothelial cells

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Nitric oxide synthase lies downstream from vascular endothelial growth factor-induced but not basic fibroblast growth factor-induced angiogenesis

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A mutant form of vascular endothelial growth factor (VEGF) that lacks VEGF receptor-2 activation retains the ability to induce vascular permeability

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Receptor-selective variants of human vascular endothelial growth factor. Generation and characterization

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Identification of vascular endothelial growth factor determinants for binding KDR and FLT-1 receptors. Generation of receptor-selective VEGF variants by site-directed mutagenesis

1 reference

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A repressor sequence in the juxtamembrane domain of Flt-1 (VEGFR-1) constitutively inhibits vascular endothelial growth factor-dependent phosphatidylinositol 3'-kinase activation and endothelial cell migration

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Kinase receptor activation (KIRA): a rapid and accurate alternative to end-point bioassays

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Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid

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The vascular endothelial growth factor (VEGF) isoforms: differential deposition into the subepithelial extracellular matrix and bioactivity of extracellular matrix-bound VEGF.

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A recombinant mutant vascular endothelial growth factor-C that has lost vascular endothelial growth factor receptor-2 binding, activation, and vascular permeability activities

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p38 MAP kinase activation by vascular endothelial growth factor mediates actin reorganization and cell migration in human endothelial cells.

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21 January 2018

Autophosphorylation of KDR in the kinase domain is required for maximal VEGF-stimulated kinase activity and receptor internalization

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Interactions of FLT-1 and KDR with phospholipase C gamma: identification of the phosphotyrosine binding sites

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The phosphorylated 1169-tyrosine containing region of flt-1 kinase (VEGFR-1) is a major binding site for PLCgamma

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21 January 2018

Identification of vascular endothelial growth factor receptor-1 tyrosine phosphorylation sites and binding of SH2 domain-containing molecules

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PKB/Akt: connecting phosphoinositide 3-kinase to cell survival and beyond

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Identifiers

10.1074/JBC.M002016200

1 reference

Europe PubMed Central

24 November 2017

1 reference

Europe PubMed Central

24 November 2017

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