(Q43513695)

24 November 2017

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title

Regulatory T-cell therapy: is it ready for the clinic? (English)

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24 November 2017

Jeffrey A Bluestone

1

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PubMed ID

15775994

24 November 2017

language of work or name

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1 April 2005

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Nature Reviews Immunology

24 November 2017

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24 November 2017

5

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24 November 2017

343-349

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24 November 2017

4

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Immunologically mediated regression of a murine lymphoma after treatment with anti-L3T4 antibody. A consequence of removing L3T4+ suppressor T cells from a host generating predominantly Lyt-2+ T cell-mediated immunity

24 November 2017

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Study on cellular events in post-thymectomy autoimmune oophoritis in mice. II. Requirement of Lyt-1 cells in normal female mice for the prevention of oophoritis

21 January 2018

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Regulatory T cells: key controllers of immunologic self-tolerance

21 January 2018

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21 January 2018

Infectious tolerance.

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B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes

21 January 2018

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Tolerance, not immunity, crucially depends on IL-2.

21 January 2018

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Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse

21 January 2018

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Compromised function of regulatory T cells in rheumatoid arthritis and reversal by anti-TNFalpha therapy

21 January 2018

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Defective suppressor function in CD4(+)CD25(+) T-cells from patients with type 1 diabetes.

21 January 2018

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Loss of functional suppression by CD4+CD25+ regulatory T cells in patients with multiple sclerosis

21 January 2018

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Immunologic tolerance maintained by CD25+ CD4+ regulatory T cells: their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance

21 January 2018

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In vivo instruction of suppressor commitment in naive T cells

21 January 2018

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Regulatory T cells generated ex vivo as an approach for the therapy of autoimmune disease

21 January 2018

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Type 1 T regulatory cells.

21 January 2018

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TGF-beta-dependent mechanisms mediate restoration of self-tolerance induced by antibodies to CD3 in overt autoimmune diabetes.

21 January 2018

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Natural versus adaptive regulatory T cells

21 January 2018

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CD4+ CD25+ regulatory T cell repertoire formation in response to varying expression of a neo-self-antigen.

21 January 2018

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Cutting Edge: CD28 Controls Peripheral Homeostasis of CD4+CD25+ Regulatory T Cells

21 January 2018

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Induction of FoxP3 and acquisition of T regulatory activity by stimulated human CD4+CD25– T cells

21 January 2018

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CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production

21 January 2018

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Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4.

21 January 2018

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Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25(+)CD4(+) regulatory cells that control intestinal inflammation

21 January 2018

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Cell contact-dependent immunosuppression by CD4(+)CD25(+) regulatory T cells is mediated by cell surface-bound transforming growth factor beta

21 January 2018

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Large-scale in vitro expansion of polyclonal human CD4(+)CD25high regulatory T cells.

21 January 2018

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Distinct roles of CTLA-4 and TGF-beta in CD4+CD25+ regulatory T cell function

21 January 2018

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Recipient-type specific CD4+CD25+ regulatory T cells favor immune reconstitution and control graft-versus-host disease while maintaining graft-versus-leukemia

21 January 2018

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CD4+CD25+ regulatory T cells preserve graft-versus-tumor activity while inhibiting graft-versus-host disease after bone marrow transplantation

21 January 2018

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Regulatory T cells and organ transplantation

21 January 2018

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Phenotype, localization, and mechanism of suppression of CD4(+)CD25(+) human thymocytes

21 January 2018

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Inhibition of human CD4(+)CD25(+high) regulatory T cell function

21 January 2018

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Human CD25+CD4+ T suppressor cell clones produce transforming growth factor beta, but not interleukin 10, and are distinct from type 1 T regulatory cells.

21 January 2018

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Human CD4(+)CD25(+) cells: a naturally occurring population of regulatory T cells.

21 January 2018

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Ex vivo isolation and characterization of CD4(+)CD25(+) T cells with regulatory properties from human blood

21 January 2018

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Identification and functional characterization of human CD4(+)CD25(+) T cells with regulatory properties isolated from peripheral blood

21 January 2018

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In vitro-expanded human CD4(+)CD25(+) T-regulatory cells can markedly inhibit allogeneic dendritic cell-stimulated MLR cultures

21 January 2018

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Human cd25(+)cd4(+) t regulatory cells suppress naive and memory T cell proliferation and can be expanded in vitro without loss of function.

21 January 2018

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A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis

21 January 2018

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In vitro generation of interleukin 10-producing regulatory CD4(+) T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)- and Th2-inducing cytokines.

21 January 2018

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IFN-alpha and IL-10 induce the differentiation of human type 1 T regulatory cells.

21 January 2018

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Tolerization of dendritic cells by T(S) cells: the crucial role of inhibitory receptors ILT3 and ILT4

21 January 2018

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A sudden decline in active membrane-bound TGF-beta impairs both T regulatory cell function and protection against autoimmune diabetes.

21 January 2018

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In vitro-expanded antigen-specific regulatory T cells suppress autoimmune diabetes

21 January 2018

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Continuous activation of autoreactive CD4+ CD25+ regulatory T cells in the steady state.

21 January 2018

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Antigen-dependent proliferation of CD4+ CD25+ regulatory T cells in vivo

21 January 2018

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CD4+CD25+ regulatory T cells control the severity of viral immunoinflammatory lesions.

21 January 2018

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CD25(+)CD4(+) regulatory T cells from the peripheral blood of asymptomatic HIV-infected individuals regulate CD4(+) and CD8(+) HIV-specific T cell immune responses in vitro and are associated with favorable clinical markers of disease status

21 January 2018

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HIV infection of naturally occurring and genetically reprogrammed human regulatory T-cells

21 January 2018

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CD25+ CD4+ T cells, expanded with dendritic cells presenting a single autoantigenic peptide, suppress autoimmune diabetes.

21 January 2018

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Direct expansion of functional CD25+ CD4+ regulatory T cells by antigen-processing dendritic cells

21 January 2018

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Ex vivo expansion of polyclonal and antigen-specific cytotoxic T lymphocytes by artificial APCs expressing ligands for the T-cell receptor, CD28 and 4-1BB.

21 January 2018

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The role of cytokines (and not only) in inducing and expanding T regulatory type 1 cells

21 January 2018

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Growth and expansion of human T regulatory type 1 cells are independent from TCR activation but require exogenous cytokines

21 January 2018

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Antigen-specific FoxP3-transduced T-cells can control established type 1 diabetes

21 January 2018

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The activity of immunoregulatory T cells mediating active tolerance is potentiated in nonobese diabetic mice by an IL-4-based retroviral gene therapy

21 January 2018

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Diabetes induced by Coxsackie virus: initiation by bystander damage and not molecular mimicry

21 January 2018

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Adoptive transfer of costimulated CD4+ T cells induces expansion of peripheral T cells and decreased CCR5 expression in HIV infection.

21 January 2018

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Induction of CD4+/CD25+ regulatory T cells by targeting of antigens to immature dendritic cells

21 January 2018

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Control of immune pathology by regulatory T cells

21 January 2018

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Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide

31 March 2020

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Recognition of the peripheral self by naturally arising CD25+ CD4+ T cell receptors

31 March 2020

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CD25+CD4+ regulatory T cells prevent graft rejection: CTLA-4- and IL-10-dependent immunoregulation of alloresponses

31 March 2020

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IL-10 Is Required for Regulatory T Cells to Mediate Tolerance to Alloantigens In Vivo

31 March 2020

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Donor CD4+CD25+ T cells promote engraftment and tolerance following MHC-mismatched hematopoietic cell transplantation

31 March 2020

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The infusion of ex vivo activated and expanded CD4(+)CD25(+) immune regulatory cells inhibits graft-versus-host disease lethality

31 March 2020

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CD4+CD25high regulatory cells in human peripheral blood

31 March 2020

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Induction and mechanism of action of transforming growth factor-beta-secreting Th3 regulatory cells

31 March 2020

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Rat CD8+ FOXP3+ T suppressor cells mediate tolerance to allogeneic heart transplants, inducing PIR-B in APC and rendering the graft invulnerable to rejection

31 March 2020

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T cell regulation: a special job or everyone's responsibility?

31 March 2020

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Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells

31 March 2020

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Quantification of regulatory T cells in patients with systemic lupus erythematosus

31 March 2020

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Immunotherapy of autoimmune encephalomyelitis with redirected CD4+CD25+ T lymphocytes

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRI1574

1 reference

24 November 2017

1 reference

PubMed ID

15775994