(Q43519306)

24 November 2017

FTDP-17 mutations compromise the ability of tau to regulate microtubule dynamics in cells (English)

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24 November 2017

Janis M Bunker

1

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24 November 2017

Kathy Kamath

2

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24 November 2017

Leslie Wilson

3

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24 November 2017

Mary Ann Jordan

4

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24 November 2017

Stuart C Feinstein

5

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24 November 2017

language of work or name

English

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publication date

21 February 2006

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Journal of Biological Chemistry

24 November 2017

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24 November 2017

281

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24 November 2017

17

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24 November 2017

11856-11863

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Microtubule plus-end-tracking proteins: mechanisms and functions.

24 November 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509420200

Microtubules meet substrate adhesions to arrange cell polarity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509420200

Microtubule-associated proteins and their essential roles during mitosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509420200

Targeting microtubules for cancer chemotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509420200

Regulation of microtubule dynamics by the neuronal growth-associated protein SCG10.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509420200

Modulation of the stathmin-like microtubule destabilizing activity of RB3, a neuron-specific member of the SCG10 family, by its N-terminal domain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509420200

The oncoprotein 18/stathmin family of microtubule destabilizers

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509420200

EB1-microtubule interactions in Xenopus egg extracts: role of EB1 in microtubule stabilization and mechanisms of targeting to microtubules

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509420200

Modulation of the dynamic instability of tubulin assembly by the microtubule-associated protein tau

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509420200

Kinetic stabilization of microtubule dynamics at steady state by tau and microtubule-binding domains of tau.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509420200

Domains of tau protein, differential phosphorylation, and dynamic instability of microtubules

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509420200

Structure of the bovine tau gene: alternatively spliced transcripts generate a protein family

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509420200

The primary structure and heterogeneity of tau protein from mouse brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509420200

Regulated phosphorylation and dephosphorylation of tau protein: effects on microtubule interaction, intracellular trafficking and neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509420200

Tau phosphorylation: physiological and pathological consequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509420200

Neurodegenerative tauopathies

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509420200

Association of missense and 5'-splice-site mutations in tau with the inherited dementia FTDP-17

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509420200

Mutation-specific functional impairments in distinct tau isoforms of hereditary FTDP-17.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509420200

Tau pathology in two Dutch families with mutations in the microtubule-binding region of tau

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509420200

Pathogenic implications of mutations in the tau gene in pallido-ponto-nigral degeneration and related neurodegenerative disorders linked to chromosome 17

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509420200

Tau gene mutation in familial progressive subcortical gliosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509420200

Mutation in the tau gene in familial multiple system tauopathy with presenile dementia

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509420200

Structure of tau exon 10 splicing regulatory element RNA and destabilization by mutations of frontotemporal dementia and parkinsonism linked to chromosome 17

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509420200

5' splice site mutations in tau associated with the inherited dementia FTDP-17 affect a stem-loop structure that regulates alternative splicing of exon 10.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509420200

Toward a unified scheme for the aggregation of tau into Alzheimer paired helical filaments

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509420200

In vitro polymerization of tau protein monitored by laser light scattering: method and application to the study of FTDP-17 mutants

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509420200

Modulation of microtubule dynamics by tau in living cells: implications for development and neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509420200

Functional interactions between the proline-rich and repeat regions of tau enhance microtubule binding and assembly

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509420200

Differential regulation of microtubule dynamics by three- and four-repeat tau: implications for the onset of neurodegenerative disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509420200

Radioimmunoassay for tubulin: a quantitative comparison of the tubulin content of different established tissue culture cells and tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509420200

Nerve growth factor-induced neurite outgrowth in PC12 cells involves the coordinate induction of microtubule assembly and assembly-promoting factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509420200

A cellophane-strip technique for culturing tissue in multipurpose culture chambers

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509420200

Resistance to Taxol in lung cancer cells associated with increased microtubule dynamics

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509420200

Dynamic instability of individual microtubules analyzed by video light microscopy: rate constants and transition frequencies

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509420200

Tau protein binds to microtubules through a flexible array of distributed weak sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509420200

Identification of a novel microtubule binding and assembly domain in the developmentally regulated inter-repeat region of tau.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509420200

Structural and functional differences between 3-repeat and 4-repeat tau isoforms. Implications for normal tau function and the onset of neurodegenetative disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509420200

Functional characterization of FTDP-17 tau gene mutations through their effects on Xenopus oocyte maturation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509420200

Taxol suppresses dynamics of individual microtubules in living human tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509420200

Mutant (R406W) human tau is hyperphosphorylated and does not efficiently bind microtubules in a neuronal cortical cell model

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509420200

Distinct FTDP-17 missense mutations in tau produce tau aggregates and other pathological phenotypes in transfected CHO cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509420200

Missense tau mutations identified in FTDP-17 have a small effect on tau-microtubule interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509420200

Promotion of hyperphosphorylation by frontotemporal dementia tau mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509420200

New synaptic bouton formation is disrupted by misregulation of microtubule stability in aPKC mutants

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509420200

JNK1 Is Required for Maintenance of Neuronal Microtubules and Controls Phosphorylation of Microtubule-Associated Proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509420200

Tau protein isoforms, phosphorylation and role in neurodegenerative disorders11These authors contributed equally to this work

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509420200

21 January 2018

Identifiers

DOI

10.1074/JBC.M509420200

1 reference

24 November 2017

1 reference