(Q43559384)

24 November 2017

title

Dominant negative function by an alternatively spliced form of the interferon-inducible protein kinase PKR. (English)

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24 November 2017

Li S

1

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24 November 2017

Koromilas AE

series ordinal

2

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24 November 2017

language of work or name

English

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publication date

5 February 2001

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Journal of Biological Chemistry

24 November 2017

published in

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24 November 2017

volume

276

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24 November 2017

issue

17

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24 November 2017

page(s)

13881-13890

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Translational control: the cancer connection

24 November 2017

cites work

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Translational control in mammalian cells

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Malignant transformation by a mutant of the IFN-inducible dsRNA-dependent protein kinase

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The emerging role of the interferon-induced PKR protein kinase as an apoptotic effector: a new face of death?

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Tumor suppressor function of the interferon-induced double-stranded RNA-activated protein kinase

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Mutants of the RNA-dependent protein kinase (PKR) lacking double-stranded RNA binding domain I can act as transdominant inhibitors and induce malignant transformation

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Autophosphorylation in the activation loop is required for full kinase activity in vivo of human and yeast eukaryotic initiation factor 2alpha kinases PKR and GCN2

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Characterization of transgenic mice with targeted disruption of the catalytic domain of the double-stranded RNA-dependent protein kinase, PKR.

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Essential role for the dsRNA-dependent protein kinase PKR in innate immunity to viral infection

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The murine double-stranded RNA-dependent protein kinase PKR is required for resistance to vesicular stomatitis virus.

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Characterization of a mammalian homolog of the GCN2 eukaryotic initiation factor 2alpha kinase

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Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls

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Proteins binding to duplexed RNA: one motif, multiple functions

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The protein kinase family: conserved features and deduced phylogeny of the catalytic domains

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Structural organization of the human gene (PKR) encoding an interferon-inducible RNA-dependent protein kinase (PKR) and differences from its mouse homolog

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Mechanism of interferon action: structure of the mouse PKR gene encoding the interferon-inducible RNA-dependent protein kinase

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The murine PKR tumor suppressor gene is rearranged in a lymphocytic leukemia.

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Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

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Eukaryotic transient-expression system based on recombinant vaccinia virus that synthesizes bacteriophage T7 RNA polymerase

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A diminished activation capacity of the interferon-inducible protein kinase PKR in human T lymphocytes

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Structural features of adenovirus 2 virus-associated RNA required for binding to the protein kinase DAI.

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Double-stranded-RNA-dependent protein kinase and TAR RNA-binding protein form homo- and heterodimers in vivo

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21 January 2018

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Mammalian eukaryotic initiation factor 2 alpha kinases functionally substitute for GCN2 protein kinase in the GCN4 translational control mechanism of yeast

21 January 2018

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Structural requirements for double-stranded RNA binding, dimerization, and activation of the human eIF-2 alpha kinase DAI in Saccharomyces cerevisiae

21 January 2018

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Regulation of the protein kinase PKR by the vaccinia virus pseudosubstrate inhibitor K3L is dependent on residues conserved between the K3L protein and the PKR substrate eIF2alpha.

21 January 2018

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The Interferon-inducible Protein Kinase PKR Modulates the Transcriptional Activation of Immunoglobulin κ Gene

21 January 2018

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Functional characterization of and cooperation between the double-stranded RNA-binding motifs of the protein kinase PKR.

21 January 2018

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Genomic features of human PKR: alternative splicing and a polymorphic CGG repeat in the 5'-untranslated region

21 January 2018

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Double-stranded (ds) RNA binding and not dimerization correlates with the activation of the dsRNA-dependent protein kinase (PKR).

21 January 2018

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Nuclear localization of the interferon-inducible protein kinase PKR in human cells and transfected mouse cells

21 January 2018

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Ultrastructural localization of interferon-inducible double-stranded RNA-activated enzymes in human cells

21 January 2018

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The double-stranded RNA activated protein kinase PKR physically associates with the tumor suppressor p53 protein and phosphorylates human p53 on serine 392 in vitro

21 January 2018

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Nuclear factor-90 of activated T-cells: A double-stranded RNA-binding protein and substrate for the double-stranded RNA-dependent protein kinase, PKR

21 January 2018

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The double-stranded RNA-binding protein X1rbpa promotes RNA strand annealing.

21 January 2018

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TAR RNA-binding protein is an inhibitor of the interferon-induced protein kinase PKR

21 January 2018

1 reference

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Oncogenic potential of TAR RNA binding protein TRBP and its regulatory interaction with RNA-dependent protein kinase PKR.

21 January 2018

1 reference

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A cis-acting element in the 3'-untranslated region of human TNF-alpha mRNA renders splicing dependent on the activation of protein kinase PKR.

21 January 2018

1 reference

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A dynamically tuned double-stranded RNA binding mechanism for the activation of antiviral kinase PKR.

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M008140200

0 references

1 reference