(Q43581680)

English

Protein kinase C-mediated inhibition of mu-opioid receptor internalization and its involvement in the development of acute tolerance to peripheral mu-agonist analgesia.

scientific article published in May 2001

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scholarly article

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Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11312280%20AND%20SRC:MED&resulttype=core&format=json

6 November 2019

Protein kinase C-mediated inhibition of mu-opioid receptor internalization and its involvement in the development of acute tolerance to peripheral mu-agonist analgesia (English)

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11312280%20AND%20SRC:MED&resulttype=core&format=json

6 November 2019

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author name string

H Ueda

1

1 reference

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6 November 2019

M Inoue

2

1 reference

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6 November 2019

T Matsumoto

3

1 reference

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6 November 2019

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publication date

1 May 2001

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6 November 2019

Journal of Neuroscience

1 reference

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6 November 2019

21

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6 November 2019

2967-2973

1 reference

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6 November 2019

9

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6 November 2019

Primary structures and expression from cDNAs of rat opioid receptor delta- and mu-subtypes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11312280

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DAMGO, a mu-opioid receptor selective agonist, distinguishes between mu- and delta-opioid receptors around their first extracellular loops.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11312280

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Morphine activates opioid receptors without causing their rapid internalization

1 reference

https://pubmed.ncbi.nlm.nih.gov/11312280

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Agonist-induced desensitization of the mu opioid receptor is determined by threonine 394 preceded by acidic amino acids in the COOH-terminal tail

1 reference

https://pubmed.ncbi.nlm.nih.gov/11312280

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional role of the spatial proximity of Asp114(2.50) in TMH 2 and Asn332(7.49) in TMH 7 of the mu opioid receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/11312280

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

G-protein coupled receptor kinases as modulators of G-protein signalling

1 reference

https://pubmed.ncbi.nlm.nih.gov/11312280

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

New hexahydroxybiphenyl derivatives as inhibitors of protein kinase C

1 reference

https://pubmed.ncbi.nlm.nih.gov/11312280

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Species and age-dependent differences of functional coupling between opioid delta-receptor and G-proteins and possible involvement of protein kinase C in striatal membranes

1 reference

https://pubmed.ncbi.nlm.nih.gov/11312280

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Agonist-dependent phosphorylation of the mouse delta-opioid receptor: involvement of G protein-coupled receptor kinases but not protein kinase C.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11312280

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

K-252 compounds, novel and potent inhibitors of protein kinase C and cyclic nucleotide-dependent protein kinases

1 reference

https://pubmed.ncbi.nlm.nih.gov/11312280

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The stimulatory effects of opioids and their possible role in the development of tolerance.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11312280

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein kinase C inhibitor potentiates the agonist-induced GTPase activity in COS cell membranes expressing delta-opioid receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/11312280

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation and internalization of the mu-opioid receptor by the newly discovered endogenous agonists, endomorphin-1 and endomorphin-2

1 reference

https://pubmed.ncbi.nlm.nih.gov/11312280

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Desensitization of the delta-opioid receptor correlates with its phosphorylation in SK-N-BE cells: involvement of a G protein-coupled receptor kinase.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11312280

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunolocalization of two mu-opioid receptor isoforms (MOR1 and MOR1B) in the rat central nervous system.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11312280

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The absence of a direct correlation between the loss of [D-Ala2, MePhe4,Gly5-ol]Enkephalin inhibition of adenylyl cyclase activity and agonist-induced mu-opioid receptor phosphorylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/11312280

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Specific G protein activation and mu-opioid receptor internalization caused by morphine, DAMGO and endomorphin I

1 reference

https://pubmed.ncbi.nlm.nih.gov/11312280

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

mu-Opioid receptor internalization: opiate drugs have differential effects on a conserved endocytic mechanism in vitro and in the mammalian brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/11312280

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intact cell binding and the relation to opioid activities in SH-SY5Y cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11312280

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular mechanisms of drug addiction

1 reference

https://pubmed.ncbi.nlm.nih.gov/11312280

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential regulation by cAMP-dependent protein kinase and protein kinase C of the mu opioid receptor coupling to a G protein-activated K+ channel

1 reference

https://pubmed.ncbi.nlm.nih.gov/11312280

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A mitogen-activated protein kinase pathway is required for mu-opioid receptor desensitization

1 reference

https://pubmed.ncbi.nlm.nih.gov/11312280

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of protein kinase C, but not of protein kinase A, blocks the development of acute antinociceptive tolerance to an intrathecally administered mu-opioid receptor agonist in the mouse

1 reference

https://pubmed.ncbi.nlm.nih.gov/11312280

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Use of recombinant adenovirus for metabolic engineering of mammalian cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11312280

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of a dominant interfering dynamin mutant in 3T3L1 adipocytes inhibits GLUT4 endocytosis without affecting insulin signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/11312280

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein kinase C involvement in homologous desensitization of delta-opioid receptor coupled to Gi1-phospholipase C activation in Xenopus oocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/11312280

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mu and delta opioid receptors are differentially desensitized by the coexpression of beta-adrenergic receptor kinase 2 and beta-arrestin 2 in xenopus oocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/11312280

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular mechanisms and regulation of opioid receptor signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/11312280

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of sequestration in G protein-coupled receptor resensitization. Regulation of beta2-adrenergic receptor dephosphorylation by vesicular acidification

1 reference

https://pubmed.ncbi.nlm.nih.gov/11312280

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

N-protein kinase C isoenzymes may be involved in the regulation of various neutrophil functions.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11312280

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A central role for beta-arrestins and clathrin-coated vesicle-mediated endocytosis in beta2-adrenergic receptor resensitization. Differential regulation of receptor resensitization in two distinct cell types

1 reference

https://pubmed.ncbi.nlm.nih.gov/11312280

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein kinase C activation increases the rate and magnitude of agonist-induced delta-opioid receptor down-regulation in NG108-15 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/11312280

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein kinase C-mediated acute tolerance to peripheral mu-opioid analgesia in the bradykinin-nociception test in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/11312280

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphorylated mu-opioid receptor purified from rat brains lacks functional coupling with Gi1, a GTP-binding protein in reconstituted lipid vesicles

1 reference

https://pubmed.ncbi.nlm.nih.gov/11312280

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tumor promotion by depleting cells of protein kinase C delta

1 reference

https://pubmed.ncbi.nlm.nih.gov/11312280

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dynamin and beta-arrestin reveal distinct mechanisms for G protein-coupled receptor internalization

1 reference

https://pubmed.ncbi.nlm.nih.gov/11312280

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intrathecal morphine in mice: a new technique

1 reference

https://pubmed.ncbi.nlm.nih.gov/11312280

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential mu opiate receptor phosphorylation and desensitization induced by agonists and phorbol esters.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11312280

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Agonist-selective endocytosis of mu opioid receptor by neurons in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/11312280

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Site mutation in the rat mu-opioid receptor demonstrates the involvement of calcium/calmodulin-dependent protein kinase II in agonist-mediated desensitization.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11312280

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The human mu opioid receptor: modulation of functional desensitization by calcium/calmodulin-dependent protein kinase and protein kinase C.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11312280

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of protein kinase C (PKC) in agonist-induced mu-opioid receptor down-regulation: II. Activation and involvement of the alpha, epsilon, and zeta isoforms of PKC.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11312280

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Agonist induced homologous desensitization of mu-opioid receptors mediated by G protein-coupled receptor kinases is dependent on agonist efficacy.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11312280

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role for G protein-coupled receptor kinase in agonist-specific regulation of mu-opioid receptor responsiveness

1 reference

https://pubmed.ncbi.nlm.nih.gov/11312280

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The newly synthesized selective Ca2+/calmodulin dependent protein kinase II inhibitor KN-93 reduces dopamine contents in PC12h cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/11312280

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of carboxyl terminus of mu-and delta-opioid receptor in agonist-induced down-regulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/11312280

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vivo molecular signal transduction of peripheral mechanisms of pain

1 reference

https://pubmed.ncbi.nlm.nih.gov/11312280

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional dissociation of mu opioid receptor signaling and endocytosis: implications for the biology of opiate tolerance and addiction.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11312280

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of PKC-isoform-specific biological actions using pharmacological approaches

1 reference

https://pubmed.ncbi.nlm.nih.gov/11312280

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein kinase cross-talk: membrane targeting of the beta-adrenergic receptor kinase by protein kinase C.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11312280

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nociceptin/orphanin FQ-induced nociceptive responses through substance P release from peripheral nerve endings in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/11312280

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vivo signal transduction of tetrodotoxin-sensitive nociceptive responses by substance P given into the planta of the mouse hind limb.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11312280

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ethical guidelines for investigations of experimental pain in conscious animals

1 reference

https://pubmed.ncbi.nlm.nih.gov/11312280

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.21-09-02967.2001

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11312280%20AND%20SRC:MED&resulttype=core&format=json

6 November 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11312280%20AND%20SRC:MED&resulttype=core&format=json

6 November 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11312280%20AND%20SRC:MED&resulttype=core&format=json

6 November 2019

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