(Q43623654)

English

Seladelpar (MBX-8025), a selective PPAR-δ agonist, in patients with primary biliary cholangitis with an inadequate response to ursodeoxycholic acid: a double-blind, randomised, placebo-controlled, phase 2, proof-of-concept study

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1 reference

Europe PubMed Central

25 November 2017

Seladelpar (MBX-8025), a selective PPAR-δ agonist, in patients with primary biliary cholangitis with an inadequate response to ursodeoxycholic acid: a double-blind, randomised, placebo-controlled, phase 2, proof-of-concept study (English)

1 reference

Europe PubMed Central

25 November 2017

ascending cholangitis

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1 reference

based on heuristic

inferred from title

11

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10 June 2020

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10 June 2020

25

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10 June 2020

Gideon M. Hirschfield

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10 June 2020

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Marek Hartleb

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10 June 2020

David E. J. Jones

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David Jones

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10 June 2020

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Pol F Boudes

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10 June 2020

Mark G Swain

3

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10 June 2020

Christopher L Bowlus

4

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10 June 2020

Michael R Galambos

5

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10 June 2020

Bruce R Bacon

6

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10 June 2020

Yvonne Doerffel

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10 June 2020

Norman Gitlin

8

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10 June 2020

Stuart C Gordon

9

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10 June 2020

Joseph A Odin

10

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10 June 2020

Markus-Alexander Wörns

12

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10 June 2020

Virginia Clark

13

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10 June 2020

Heinz Hartmann

15

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10 June 2020

Mark E Jonas

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10 June 2020

Andreas E Kremer

17

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10 June 2020

George F Mells

18

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10 June 2020

Peter Buggisch

19

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10 June 2020

Bradley L Freilich

20

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10 June 2020

Cynthia Levy

21

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10 June 2020

John M Vierling

22

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10 June 2020

David E Bernstein

23

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10 June 2020

Fedja Rochling

26

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10 June 2020

Hemant Shah

27

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10 June 2020

Mitchell L Shiffman

28

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10 June 2020

John H Smith

29

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10 June 2020

Yun-Jung Choi

30

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10 June 2020

Alexandra Steinberg

31

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10 June 2020

Monika Varga

32

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10 June 2020

Harinder Chera

33

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10 June 2020

Robert Martin

34

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10 June 2020

Charles A McWherter

35

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10 June 2020

publication date

14 August 2017

1 reference

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25 November 2017

The lancet. Gastroenterology & hepatology

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10 June 2020

2

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10 June 2020

10

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10 June 2020

716-726

1 reference

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10 June 2020

The immunobiology and pathophysiology of primary biliary cirrhosis

1 reference

https://api.crossref.org/works/10.1016%2FS2468-1253%2817%2930246-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Primary biliary cirrhosis

1 reference

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7 January 2021

based on heuristic

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Ursodiol for the long-term treatment of primary biliary cirrhosis. The UDCA-PBC Study Group.

1 reference

https://api.crossref.org/works/10.1016%2FS2468-1253%2817%2930246-7

7 January 2021

based on heuristic

inferred from DOI database lookup

A Placebo-Controlled Trial of Obeticholic Acid in Primary Biliary Cholangitis

1 reference

https://api.crossref.org/works/10.1016%2FS2468-1253%2817%2930246-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Combined analysis of randomized controlled trials of ursodeoxycholic acid in primary biliary cirrhosis

1 reference

https://api.crossref.org/works/10.1016%2FS2468-1253%2817%2930246-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Biochemical response to ursodeoxycholic acid and long-term prognosis in primary biliary cirrhosis

1 reference

https://api.crossref.org/works/10.1016%2FS2468-1253%2817%2930246-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Early primary biliary cirrhosis: biochemical response to treatment and prediction of long-term outcome

1 reference

https://api.crossref.org/works/10.1016%2FS2468-1253%2817%2930246-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Improved prognosis of patients with primary biliary cirrhosis that have a biochemical response to ursodeoxycholic acid

1 reference

https://api.crossref.org/works/10.1016%2FS2468-1253%2817%2930246-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Levels of alkaline phosphatase and bilirubin are surrogate end points of outcomes of patients with primary biliary cirrhosis: an international follow-up study

1 reference

https://api.crossref.org/works/10.1016%2FS2468-1253%2817%2930246-7

7 January 2021

based on heuristic

inferred from DOI database lookup

6alpha-ethyl-chenodeoxycholic acid (6-ECDCA), a potent and selective FXR agonist endowed with anticholestatic activity.

1 reference

https://api.crossref.org/works/10.1016%2FS2468-1253%2817%2930246-7

7 January 2021

based on heuristic

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Management of cholestatic disease in 2017.

1 reference

https://api.crossref.org/works/10.1016%2FS2468-1253%2817%2930246-7

7 January 2021

based on heuristic

inferred from DOI database lookup

MBX-8025, a novel peroxisome proliferator receptor-delta agonist: lipid and other metabolic effects in dyslipidemic overweight patients treated with and without atorvastatin

1 reference

https://api.crossref.org/works/10.1016%2FS2468-1253%2817%2930246-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Hepatic PPARs: their role in liver physiology, fibrosis and treatment

1 reference

https://api.crossref.org/works/10.1016%2FS2468-1253%2817%2930246-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Peroxisome proliferator activated receptor-δ: the middle child vies for attention

1 reference

https://api.crossref.org/works/10.1016%2FS2468-1253%2817%2930246-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Pilot study: fenofibrate for patients with primary biliary cirrhosis and an incomplete response to ursodeoxycholic acid.

1 reference

https://api.crossref.org/works/10.1016%2FS2468-1253%2817%2930246-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Fibrates as adjuvant therapy for chronic cholestatic liver disease: its time has come

1 reference

https://api.crossref.org/works/10.1016%2FS2468-1253%2817%2930246-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Protection from liver fibrosis by a peroxisome proliferator-activated receptor δ agonist

1 reference

https://api.crossref.org/works/10.1016%2FS2468-1253%2817%2930246-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Peroxisome proliferator-activated receptor alpha is restricted to hepatic parenchymal cells, not Kupffer cells: implications for the mechanism of action of peroxisome proliferators in hepatocarcinogenesis.

1 reference

https://api.crossref.org/works/10.1016%2FS2468-1253%2817%2930246-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Liver X receptor β and peroxisome proliferator-activated receptor δ regulate cholesterol transport in murine cholangiocytes

1 reference

https://api.crossref.org/works/10.1016%2FS2468-1253%2817%2930246-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Peroxisome proliferator-activated receptor delta activation leads to increased transintestinal cholesterol efflux

1 reference

https://api.crossref.org/works/10.1016%2FS2468-1253%2817%2930246-7

7 January 2021

based on heuristic

inferred from DOI database lookup

PPAR-delta senses and orchestrates clearance of apoptotic cells to promote tolerance

1 reference

https://api.crossref.org/works/10.1016%2FS2468-1253%2817%2930246-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Alternative M2 activation of Kupffer cells by PPARdelta ameliorates obesity-induced insulin resistance.

1 reference

https://api.crossref.org/works/10.1016%2FS2468-1253%2817%2930246-7

7 January 2021

based on heuristic

inferred from DOI database lookup

The selective peroxisome proliferator-activated receptor-delta agonist seladelpar reverses nonalcoholic steatohepatitis pathology by abrogating lipotoxicity in diabetic obese mice.

1 reference

https://api.crossref.org/works/10.1016%2FS2468-1253%2817%2930246-7

7 January 2021

based on heuristic

inferred from DOI database lookup

A203 ACTIVITY OF MBX-8025, A POTENT AND SELECTIVE PPAR-δ AGONIST, ON BIOCHEMICAL MARKERS OF CHOLESTASIS

1 reference

https://api.crossref.org/works/10.1016%2FS2468-1253%2817%2930246-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Efficacy of obeticholic acid in patients with primary biliary cirrhosis and inadequate response to ursodeoxycholic acid.

1 reference

https://api.crossref.org/works/10.1016%2FS2468-1253%2817%2930246-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Opposite regulation of the rat and human cytosolic aspartate aminotransferase genes by fibrates

1 reference

https://api.crossref.org/works/10.1016%2FS2468-1253%2817%2930246-7

7 January 2021

based on heuristic

inferred from DOI database lookup

PPARalpha regulates the hepatotoxic biomarker alanine aminotransferase (ALT1) gene expression in human hepatocytes

1 reference

https://api.crossref.org/works/10.1016%2FS2468-1253%2817%2930246-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Biomarkers of liver cell death

1 reference

https://api.crossref.org/works/10.1016%2FS2468-1253%2817%2930246-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Bile acid-induced liver toxicity: relation to the hydrophobic-hydrophilic balance of bile acids.

1 reference

https://api.crossref.org/works/10.1016%2FS2468-1253%2817%2930246-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Bezafibrate normalizes alkaline phosphatase in primary biliary cirrhosis patients with incomplete response to ursodeoxycholic acid

1 reference

https://api.crossref.org/works/10.1016%2FS2468-1253%2817%2930246-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Effect of bezafibrate on plasma homocysteine concentration in men with lower extremity arterial disease

1 reference

https://api.crossref.org/works/10.1016%2FS2468-1253%2817%2930246-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Fenofibrate, homocysteine and renal function.

1 reference

https://api.crossref.org/works/10.1016%2FS2468-1253%2817%2930246-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Elafibranor, an Agonist of the Peroxisome Proliferator-Activated Receptor-α and -δ, Induces Resolution of Nonalcoholic Steatohepatitis Without Fibrosis Worsening

1 reference

https://api.crossref.org/works/10.1016%2FS2468-1253%2817%2930246-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Effect of fenofibrate on kidney function: a 6-week randomized crossover trial in healthy people

1 reference

https://api.crossref.org/works/10.1016%2FS2468-1253%2817%2930246-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Benefits and safety of long-term fenofibrate therapy in people with type 2 diabetes and renal impairment: the FIELD Study.

1 reference

https://api.crossref.org/works/10.1016%2FS2468-1253%2817%2930246-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Reversibility of fenofibrate therapy-induced renal function impairment in ACCORD type 2 diabetic participants

1 reference

https://api.crossref.org/works/10.1016%2FS2468-1253%2817%2930246-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Fenofibrate increases creatininemia by increasing metabolic production of creatinine

1 reference

https://api.crossref.org/works/10.1016%2FS2468-1253%2817%2930246-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Monitoring hepatic cholesterol 7alpha-hydroxylase activity by assay of the stable bile acid intermediate 7alpha-hydroxy-4-cholesten-3-one in peripheral blood

1 reference

https://api.crossref.org/works/10.1016%2FS2468-1253%2817%2930246-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Bile acid signaling in metabolic disease and drug therapy

1 reference

https://api.crossref.org/works/10.1016%2FS2468-1253%2817%2930246-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Liver alkaline phosphatase: a missing link between choleresis and biliary inflammation

1 reference

https://api.crossref.org/works/10.1016%2FS2468-1253%2817%2930246-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Separating Tumorigenicity from Bile Acid Regulatory Activity for Endocrine Hormone FGF19.

1 reference

https://api.crossref.org/works/10.1016%2FS2468-1253%2817%2930246-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1016/S2468-1253(17)30246-7

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28818518%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28818518%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

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