(Q43682059)

25 November 2017

title

Nanobodies and their potential applications (English)

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25 November 2017

2

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25 November 2017

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25 November 2017

author name string

Gholamreza Hassanzadeh-Ghassabeh

series ordinal

1

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25 November 2017

Pieter De Pauw

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3

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25 November 2017

Cécile Vincke

series ordinal

4

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25 November 2017

publication date

1 June 2013

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25 November 2017

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25 November 2017

volume

8

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25 November 2017

issue

6

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25 November 2017

page(s)

1013-1026

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Biopharmaceutical drug discovery using novel protein scaffolds

25 November 2017

cites work

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Naturally occurring antibodies devoid of light chains

21 January 2018

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A case of convergence: why did a simple alternative to canonical antibodies arise in sharks and camels?

21 January 2018

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Antibody repertoire development in camelids

21 January 2018

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Efficient cancer therapy with a nanobody-based conjugate

21 January 2018

1 reference

High affinity nanobodies against the Trypanosome brucei VSG are potent trypanolytic agents that block endocytosis

21 January 2018

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Generation of single domain antibody fragments derived from camelids and generation of manifold constructs

21 January 2018

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Immunological applications of single-domain llama recombinant antibodies isolated from a naïve library

21 January 2018

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Exploring the Capacity of Minimalist Protein Interfaces: Interface Energetics and Affinity Maturation to Picomolar KD of a Single-domain Antibody with a Flat Paratope

21 January 2018

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Molecular basis for the preferential cleft recognition by dromedary heavy-chain antibodies

21 January 2018

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'Camelising' human antibody fragments: NMR studies on VH domains.

21 January 2018

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General strategy to humanize a camelid single-domain antibody and identification of a universal humanized nanobody scaffold

21 January 2018

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CXCR4 nanobodies (VHH-based single variable domains) potently inhibit chemotaxis and HIV-1 replication and mobilize stem cells

21 January 2018

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Single domain antibodies from llama effectively and specifically block T cell ecto-ADP-ribosyltransferase ART2.2 in vivo

21 January 2018

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Generation of heavy-chain-only antibodies in mice

21 January 2018

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A bacterial-two-hybrid selection system for one-step isolation of intracellularly functional Nanobodies

21 January 2018

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Monoclonal antibodies isolated without screening by analyzing the variable-gene repertoire of plasma cells

21 January 2018

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By-passing in vitro screening--next generation sequencing technologies applied to antibody display and in silico candidate selection

21 January 2018

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Generation of anti-infectome/anti-proteome nanobodies

21 January 2018

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Chaperonin GroEL a Brucella immunodominant antigen identified using Nanobody and MALDI-TOF-MS technologies

21 January 2018

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Identification of broadly protective human antibodies to Pseudomonas aeruginosa exopolysaccharide Psl by phenotypic screening

21 January 2018

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Biopanning and rapid analysis of selective interactive ligands

21 January 2018

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Selection and characterization of KDEL-specific VHH antibody fragments and their application in the study of ER resident protein expression

21 January 2018

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Kinetic and affinity predictions of a protein-protein interaction using multivariate experimental design

21 January 2018

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A system for the continuous directed evolution of biomolecules

21 January 2018

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Protein transduction domain delivery of therapeutic macromolecules

21 January 2018

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Mammalian cell penetration, siRNA transfection, and DNA transfection by supercharged proteins

21 January 2018

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Direct injection of functional single-domain antibodies from E. coli into human cells

21 January 2018

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Beneficial properties of single-domain antibody fragments for application in immunoaffinity purification and immuno-perfusion chromatography

21 January 2018

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A versatile nanotrap for biochemical and functional studies with fluorescent fusion proteins

21 January 2018

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Specific immuno capturing of the staphylococcal superantigen toxic-shock syndrome toxin-1 in plasma

21 January 2018

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Improved anti-IgG and HSA affinity ligands: clinical application of VHH antibody technology

21 January 2018

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Crystal structure of the intrinsically flexible addiction antidote MazE

21 January 2018

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Toward chaperone-assisted crystallography: Protein engineering enhancement of crystal packing and X-ray phasing capabilities of a camelid single-domain antibody (VHH) scaffold

21 January 2018

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Structure of a nanobody-stabilized active state of the β(2) adrenoceptor

21 January 2018

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Engineering of recombinant crystallization chaperones

21 January 2018

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A camelid antibody fragment inhibits the formation of amyloid fibrils by human lysozyme

21 January 2018

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Atomic structure of a nanobody-trapped domain-swapped dimer of an amyloidogenic 2-microglobulin variant

21 January 2018

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Directed selection of a conformational antibody domain that prevents mature amyloid fibril formation by stabilizing Abeta protofibrils

21 January 2018

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Engineering antibodies and proteins for molecular in vivo imaging

21 January 2018

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Selection of genetically encoded fluorescent single domain antibodies engineered for efficient expression in Escherichia coli

21 January 2018

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A simple, versatile method for GFP-based super-resolution microscopy via nanobodies

21 January 2018

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Single domain intracellular antibodies from diverse libraries: emphasizing dual functions of LMO2 protein interactions using a single VH domain

21 January 2018

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Nanobody-induced perturbation of LFA-1/L-plastin phosphorylation impairs MTOC docking, immune synapse formation and T cell activation

21 January 2018

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Production, characterization and in vitro testing of HBcAg-specific VHH intrabodies

21 January 2018

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Fusion to a highly charged proteasomal retargeting sequence increases soluble cytoplasmic expression and efficacy of diverse anti-synuclein intrabodies

21 January 2018

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Fluorescent fusion protein knockout mediated by anti-GFP nanobody.

21 January 2018

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Oriented conjugates of single-domain antibodies and quantum dots: toward a new generation of ultrasmall diagnostic nanoprobes

21 January 2018

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Magnetosome expression of functional camelid antibody fragments (nanobodies) in Magnetospirillum gryphiswaldense.

21 January 2018

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Immuno-imaging using nanobodies

21 January 2018

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Nanobody-based targeting of the macrophage mannose receptor for effective in vivo imaging of tumor-associated macrophages.

21 January 2018

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Nanobodies targeting mouse/human VCAM1 for the nuclear imaging of atherosclerotic lesions

21 January 2018

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Using microdialysis to analyse the passage of monovalent nanobodies through the blood-brain barrier

21 January 2018

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Strategies for extended serum half-life of protein therapeutics

21 January 2018

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Protein PEGylation decreases observed target association rates via a dual blocking mechanism

21 January 2018

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Prolonged in vivo residence times of llama single-domain antibody fragments in pigs by binding to porcine immunoglobulins

21 January 2018

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Improved tumor targeting of anti-epidermal growth factor receptor Nanobodies through albumin binding: taking advantage of modular Nanobody technology

21 January 2018

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Kinetic analysis of novel mono- and multivalent VHH-fragments and their application for molecular imaging of brain tumours.

21 January 2018

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Research strategies to improve snakebite treatment: challenges and progress.

21 January 2018

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Immunological aspects of scorpion toxins: current status and perspectives

21 January 2018

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Pre-clinical studies of toxin-specific nanobodies: evidence of in vivo efficacy to prevent fatal disturbances provoked by scorpion envenoming

21 January 2018

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Single domain antibodies: promising experimental and therapeutic tools in infection and immunity

21 January 2018

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Nanobody; an old concept and new vehicle for immunotargeting

21 January 2018

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The culprit behind amyloid beta peptide related neurotoxicity in Alzheimer's disease: oligomer size or conformation?

21 January 2018

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Single-domain antibodies recognize selectively small oligomeric forms of amyloid beta, prevent Abeta-induced neurotoxicity and inhibit fibril formation

21 January 2018

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Nanobodies as structural probes of protein misfolding and fibril formation

21 January 2018

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Cell-penetrating anti-GFAP VHH and corresponding fluorescent fusion protein VHH-GFP spontaneously cross the blood-brain barrier and specifically recognize astrocytes: application to brain imaging

21 January 2018

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Formatted anti-tumor necrosis factor alpha VHH proteins derived from camelids show superior potency and targeting to inflamed joints in a murine model of collagen-induced arthritis.

21 January 2018

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Efficient inhibition of EGFR signaling and of tumour growth by antagonistic anti-EFGR Nanobodies

21 January 2018

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A biparatopic anti-EGFR nanobody efficiently inhibits solid tumour growth.

21 January 2018

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Nanobody-coupled microbubbles as novel molecular tracer

21 January 2018

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Specific cell targeting with nanobody conjugated branched gold nanoparticles for photothermal therapy

21 January 2018

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Targeting epidermal growth factor receptor in tumors: from conventional monoclonal antibodies via heavy chain-only antibodies to nanobodies.

21 January 2018

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Biotinylated bionanocapsules for displaying diverse ligands toward cell-specific delivery

21 January 2018

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Nanobody-shell functionalized thermosensitive core-crosslinked polymeric micelles for active drug targeting.

21 January 2018

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Advances in bispecific biotherapeutics for the treatment of cancer

21 January 2018

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Bispecific T-cell engaging antibodies for cancer therapy

21 January 2018

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Single-domain antibodies as building blocks for novel therapeutics

21 January 2018

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Bispecific antibodies for cancer therapy: the light at the end of the tunnel?

21 January 2018

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Clinical experience with gene therapy and bispecific antibodies for T cell-based therapy of cancer

21 January 2018

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Anti-MUC1 nanobody can redirect T-body cytotoxic effector function

21 January 2018

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A bispecific nanobody to provide full protection against lethal scorpion envenoming

21 January 2018

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21 January 2018

Identifiers

DOI

10.2217/NNM.13.86

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25 November 2017

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