(Q43683966)

2 July 2019

title

Simvastatin induces neuroprotection in 6-OHDA-lesioned PC12 via the PI3K/AKT/caspase 3 pathway and anti-inflammatory responses (English)

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2 July 2019

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Yun-Qi Xu

1

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2 July 2019

Ling Long

2

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2 July 2019

Jun-Qiang Yan

3

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2 July 2019

Lei Wei

4

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2 July 2019

Meng-Qiu Pan

5

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2 July 2019

Hui-Min Gao

6

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2 July 2019

Peng Zhou

7

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2 July 2019

Mei Liu

8

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2 July 2019

Can-Sheng Zhu

9

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2 July 2019

Bei-Sha Tang

10

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2 July 2019

Qing Wang

11

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2 July 2019

publication date

28 December 2012

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2 July 2019

CNS Neuroscience & Therapeutics

published in

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2 July 2019

volume

19

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2 July 2019

issue

3

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2 July 2019

page(s)

170-177

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2 July 2019

Absence of MPTP-induced neuronal death in mice lacking the dopamine transporter.

cites work

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12 December 2020

The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals

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12 December 2020

HMG-CoA reductase inhibitors (statins) increase endothelial progenitor cells via the PI 3-kinase/Akt pathway

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12 December 2020

Down-regulation of hypoxia-inducible factor-2 in PC12 cells by nerve growth factor stimulation

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12 December 2020

Dopamine transporter mRNA content in human substantia nigra decreases precipitously with age

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12 December 2020

PI3 kinase enhancer–Homer complex couples mGluRI to PI3 kinase, preventing neuronal apoptosis

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12 December 2020

Assessment of neuroimaging techniques as biomarkers of the progression of Parkinson's disease

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12 December 2020

Astrocyte apoptosis: implications for neuroprotection

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12 December 2020

Neurotrophin-3-induced PI-3 kinase/Akt signaling rescues cortical neurons from apoptosis.

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12 December 2020

PIKE/nuclear PI 3-kinase signaling mediates the antiapoptotic actions of NGF in the nucleus

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12 December 2020

Simvastatin prevents 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced striatal dopamine depletion and protein tyrosine nitration in mice

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12 December 2020

Akt is altered in an animal model of Huntington's disease and in patients

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12 December 2020

Lovastatin inhibits the growth and survival pathway of phosphoinositide 3-kinase/protein kinase B in immortalized rat brain neuroblasts

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12 December 2020

Dopamine-glutamate interaction and antipsychotics mechanism of action: implication for new pharmacological strategies in psychosis.

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12 December 2020

Erythropoietin protects against 6-hydroxydopamine-induced dopaminergic cell death

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12 December 2020

Dopamine D1 receptors co-distribute with N-methyl-D-aspartic acid type-1 subunits and modulate synaptically-evoked N-methyl-D-aspartic acid currents in rat basolateral amygdala.

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12 December 2020

Insulin signaling in the central nervous system: learning to survive

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12 December 2020

Acetaldehyde promotes rapamycin-dependent activation of p70(S6K) and glucose uptake despite inhibition of Akt and mTOR in dopaminergic SH-SY5Y human neuroblastoma cells

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12 December 2020

Chronic alcohol consumption alters mammalian target of rapamycin (mTOR), reduces ribosomal p70s6 kinase and p4E-BP1 levels in mouse cerebral cortex

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12 December 2020

Synaptic scaffolding molecule alpha is a scaffold to mediate N-methyl-D-aspartate receptor-dependent RhoA activation in dendrites.

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12 December 2020

Minocycline protects the blood-brain barrier and reduces edema following intracerebral hemorrhage in the rat.

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12 December 2020

Simvastatin prevents the inflammatory process and the dopaminergic degeneration induced by the intranigral injection of lipopolysaccharide

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12 December 2020

Simvastatin-mediated upregulation of VEGF and BDNF, activation of the PI3K/Akt pathway, and increase of neurogenesis are associated with therapeutic improvement after traumatic brain injury

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12 December 2020

Lovastatin induces neuroprotection through tumor necrosis factor receptor 2 signaling pathways.

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12 December 2020

Protective effects of erythropoietin on tau phosphorylation induced by beta-amyloid

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12 December 2020

Intracellular signaling pathways involved in post-mitotic dopaminergic PC12 cell death induced by 6-hydroxydopamine

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12 December 2020

Simvastatin attenuation of cerebral vasospasm after subarachnoid hemorrhage in rats via increased phosphorylation of Akt and endothelial nitric oxide synthase

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12 December 2020

Regulation of ceramide-induced neuronal death: cell metabolism meets neurodegeneration.

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12 December 2020

High dose of simvastatin induces hyperlocomotive and anxiolytic-like activities: The association with the up-regulation of NMDA receptor binding in the rat brain

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12 December 2020

Simvastatin attenuates cerebral vasospasm and improves outcomes by upregulation of PI3K/Akt pathway in a rat model of subarachnoid hemorrhage.

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12 December 2020

Statins: mechanisms of neuroprotection

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12 December 2020

Overexpression of human selenoprotein H in neuronal cells ameliorates ultraviolet irradiation-induced damage by modulating cell signaling pathways

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12 December 2020

L-DOPA-induced neurotoxicity is reduced by the activation of the PI3K signaling pathway

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12 December 2020

Simvastatin inhibits the activation of p21ras and prevents the loss of dopaminergic neurons in a mouse model of Parkinson's disease

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12 December 2020

Statins: multiple neuroprotective mechanisms in neurodegenerative diseases

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12 December 2020

The dopamine transporter is differentially regulated after dopaminergic lesion

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12 December 2020

3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors in the treatment of central nervous system diseases

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12 December 2020

Lovastatin inhibits VEGFR and AKT activation: synergistic cytotoxicity in combination with VEGFR inhibitors

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12 December 2020

Interaction between α-synuclein and tau in Parkinson's disease comment on Wills et al.: elevated tauopathy and α-synuclein pathology in postmortem Parkinson's disease brains with and without dementia. Exp Neurol 2010; 225: 210-218.

1 reference

12 December 2020

Interferon-β induces apoptosis in human SH-SY5Y neuroblastoma cells through activation of JAK-STAT signaling and down-regulation of PI3K/Akt pathway

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12 December 2020

Mechanisms of statin treatment in cerebral vasospasm

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12 December 2020

Blockade of the Ras/MEK/ERK and Ras/PI3K/Akt pathways by statins reduces the expression of bFGF, HGF, and TGF-β as angiogenic factors in mouse osteosarcoma

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12 December 2020

Protective effects of pituitary adenylate cyclase-activating polypeptide (PACAP) against apoptosis

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12 December 2020

Phosphoinositide 3-kinase enhancer regulates neuronal dendritogenesis and survival in neocortex

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12 December 2020

Study of the pathways involved in apoptosis induced by PI3K inhibition in cerebellar granule neurons.

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12 December 2020

Simvastatin prevents dopaminergic neurodegeneration in experimental parkinsonian models: the association with anti-inflammatory responses

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12 December 2020

PIKE-mediated PI3-kinase activity is required for AMPA receptor surface expression

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12 December 2020

CD200-CD200R dysfunction exacerbates microglial activation and dopaminergic neurodegeneration in a rat model of Parkinson's disease

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12 December 2020

α7 nicotinic acetylcholine receptor agonism confers neuroprotection through GSK-3β inhibition in a mouse model of intracerebral hemorrhage

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12 December 2020

Extracellular signal-regulated kinase is involved in alpha-synuclein-induced mitochondrial dynamic disorders by regulating dynamin-like protein 1.

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12 December 2020

Kinases and kinase signaling pathways: potential therapeutic targets in Parkinson's disease

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12 December 2020

The role of alpha-synuclein in melanin synthesis in melanoma and dopaminergic neuronal cells

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12 December 2020

Identifiers

DOI

10.1111/CNS.12053

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2 July 2019

PMCID

6493537

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2 July 2019

PubMed ID

23279934

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2 July 2019