(Q43690759)

English

(E)-5-(2-bromovinyl)-2'-deoxyuridine potentiates ganciclovir-mediated cytotoxicity on herpes simplex virus-thymidine kinase--expressing cells

scientific article published in May 2001

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scholarly article

1 reference

Europe PubMed Central

25 November 2017

(E)-5-(2-bromovinyl)-2'-deoxyuridine potentiates ganciclovir-mediated cytotoxicity on herpes simplex virus-thymidine kinase--expressing cells (English)

1 reference

Europe PubMed Central

25 November 2017

author name string

Hamel W

1

1 reference

Europe PubMed Central

25 November 2017

Zirkel D

2

1 reference

Europe PubMed Central

25 November 2017

Mehdorn HM

3

1 reference

Europe PubMed Central

25 November 2017

Westphal M

4

1 reference

Europe PubMed Central

25 November 2017

Israel MA

5

1 reference

Europe PubMed Central

25 November 2017

publication date

1 May 2001

1 reference

Europe PubMed Central

25 November 2017

Cancer Gene Therapy

1 reference

Europe PubMed Central

25 November 2017

8

1 reference

Europe PubMed Central

25 November 2017

5

1 reference

Europe PubMed Central

25 November 2017

388-396

1 reference

Europe PubMed Central

25 November 2017

https://scigraph.springernature.com/pub.10.1038/sj.cgt.7700322

0 references

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Inhibition by acyclovir of cell growth and DNA synthesis of cells biochemically transformed with Herpesvirus genetic information

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Murine mammary FM3A carcinoma cells transformed with the herpes simplex virus type 1 thymidine kinase gene are highly sensitive to the growth-inhibitory properties of (E)-5-(2-bromovinyl)-2'-deoxyuridine and related compounds

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Curability of tumors bearing herpes thymidine kinase genes transferred by retroviral vectors

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Metabolic suicide genes in gene therapy

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In Vivo Gene Transfer with Retroviral Vector-Producer Cells for Treatment of Experimental Brain Tumors

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Therapy of malignant brain tumors by intratumoral implantation of retroviral vector-producing cells.

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The "bystander effect": association of U-87 cell death with ganciclovir-mediated apoptosis of nearby cells and lack of effect in athymic mice.

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On the mechanism of selective inhibition of herpesvirus replication by (E)-5-(2-bromovinyl)-2'-deoxyuridine

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Oral BVDU treatment of varicella and zoster in children with cancer

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Oral bromovinyldeoxyuridine therapy for herpes simplex and varicella-zoster virus infections in severely immunosuppressed patients: a preliminary clinical trial

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Oral (E)-5-(2-bromovinyl)-2'-deoxyuridine treatment of severe herpes zoster in cancer patients

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Metabolic fate of (E)-5-(2-bromovinyl)-2'-deoxyuridine in herpes simplex virus- and mock-infected cells

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Varicella-zoster virus thymidine kinase gene and antiherpetic pyrimidine nucleoside analogues in a combined gene/chemotherapy treatment for cancer.

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Redesign of retrovirus packaging cell lines to avoid recombination leading to helper virus production

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Use of retroviral vectors for gene transfer and expression

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The extent of heterocellular communication mediated by gap junctions is predictive of bystander tumor cytotoxicity in vitro

1 reference

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Strategies for the measurement of the inhibitory effects of thymidine analogs on the activity of thymidylate synthase in intact murine leukemia L1210 cells

1 reference

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In vitro evidence that metabolic cooperation is responsible for the bystander effect observed with HSV tk retroviral gene therapy

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Bystander killing of cancer cells by herpes simplex virus thymidine kinase gene is mediated by connexins

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Glioma cells transduced with an Escherichia coli CD/HSV-1 TK fusion gene exhibit enhanced metabolic suicide and radiosensitivity

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Synergistic anticancer effects of ganciclovir/thymidine kinase and 5-fluorocytosine/cytosine deaminase gene therapies

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Double suicide gene (cytosine deaminase and herpes simplex virus thymidine kinase) but not single gene transfer allows reliable elimination of tumor cells in vivo

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Anti-recombinogenic and convertible co-mutagenic effects of (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU) and other 5-substituted pyrimidine nucleoside analogs in S. cerevisiae MP1.

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Targeted killing of migrating glioma cells by injection of HTK-modified glioma cells.

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Potential of Varicella zoster virus thymidine kinase as a suicide gene in breast cancer cells

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Bystander effect of purine nucleoside analogues in HSV-1 tk suicide gene therapy is superior to that of pyrimidine nucleoside analogues

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Comparative in vitro and in vivo cytotoxic activity of (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU) and its arabinosyl derivative, (E)-5-(2-bromovinyl)-1-beta-D-arabinofuranosyluracil (BVaraU), against tumor cells expressing either the Varicella zost

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Identifiers

10.1038/SJ.CGT.7700322

1 reference

Europe PubMed Central

25 November 2017

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1 reference

Europe PubMed Central

25 November 2017

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