(Q43756965)

English

A physiologically based pharmacokinetic analysis of capecitabine, a triple prodrug of 5-FU, in humans: the mechanism for tumor-selective accumulation of 5-FU.

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

26 November 2017

A physiologically based pharmacokinetic analysis of capecitabine, a triple prodrug of 5-FU, in humans: the mechanism for tumor-selective accumulation of 5-FU. (English)

1 reference

Europe PubMed Central

PubMed publication ID

26 November 2017

1 reference

based on heuristic

inferred from title

pharmacokinetics

1 reference

based on heuristic

inferred from title

author name string

Y Tsukamoto

1

1 reference

Europe PubMed Central

PubMed publication ID

26 November 2017

Y Kato

2

1 reference

Europe PubMed Central

PubMed publication ID

26 November 2017

M Ura

3

1 reference

Europe PubMed Central

PubMed publication ID

26 November 2017

I Horii

4

1 reference

Europe PubMed Central

PubMed publication ID

26 November 2017

H Ishitsuka

5

1 reference

Europe PubMed Central

PubMed publication ID

26 November 2017

H Kusuhara

6

1 reference

Europe PubMed Central

PubMed publication ID

26 November 2017

Y Sugiyama

7

1 reference

Europe PubMed Central

PubMed publication ID

26 November 2017

publication date

1 August 2001

1 reference

Europe PubMed Central

PubMed publication ID

26 November 2017

Pharmaceutical Research

1 reference

Europe PubMed Central

PubMed publication ID

26 November 2017

18

1 reference

Europe PubMed Central

PubMed publication ID

26 November 2017

8

1 reference

Europe PubMed Central

PubMed publication ID

26 November 2017

1190-1202

1 reference

Europe PubMed Central

PubMed publication ID

26 November 2017

Preliminary studies of a novel oral fluoropyrimidine carbamate: capecitabine

1 reference

https://pubmed.ncbi.nlm.nih.gov/11587492

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tumor selective delivery of 5-fluorouracil by capecitabine, a new oral fluoropyrimidine carbamate, in human cancer xenografts

1 reference

https://pubmed.ncbi.nlm.nih.gov/11587492

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dihydropyrimidine dehydrogenase inactivation and 5-fluorouracil pharmacokinetics: allometric scaling of animal data, pharmacokinetics and toxicodynamics of 5-fluorouracil in humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/11587492

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Physiologically based kinetic model of effector cell biodistribution in mammals: implications for adoptive immunotherapy.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11587492

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical pharmacology of 5-fluorouracil

1 reference

https://pubmed.ncbi.nlm.nih.gov/11587492

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Influence of pH on the uptake of 5-fluorouracil into isolated tumour cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/11587492

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lidocaine disposition kinetics in monkey and man. I. Prediction by a perfusion model.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11587492

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11587492

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prodrugs and site-specific drug delivery

1 reference

https://pubmed.ncbi.nlm.nih.gov/11587492

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetics of 1-beta-D-arabinofuranosylcytosine (ARA-C) deamination in several species.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11587492

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Animal scale-up

1 reference

https://pubmed.ncbi.nlm.nih.gov/11587492

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Methotrexate Pharmacokinetics

1 reference

https://pubmed.ncbi.nlm.nih.gov/11587492

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prediction of intestinal first-pass effect of phenacetin in the rat from enzyme kinetic data--correlation with in vivo data using mucosal blood flow

1 reference

https://pubmed.ncbi.nlm.nih.gov/11587492

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Physiological parameters in laboratory animals and humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/11587492

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phase I and pharmacologic study of intermittent twice-daily oral therapy with capecitabine in patients with advanced and/or metastatic cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/11587492

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Design of a novel oral fluoropyrimidine carbamate, capecitabine, which generates 5-fluorouracil selectively in tumours by enzymes concentrated in human liver and cancer tissue

1 reference

https://pubmed.ncbi.nlm.nih.gov/11587492

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A human capecitabine excretion balance and pharmacokinetic study after administration of a single oral dose of 14C-labelled drug

1 reference

https://pubmed.ncbi.nlm.nih.gov/11587492

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Positive correlation between the efficacy of capecitabine and doxifluridine and the ratio of thymidine phosphorylase to dihydropyrimidine dehydrogenase activities in tumors in human cancer xenografts

1 reference

https://pubmed.ncbi.nlm.nih.gov/11587492

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of phospholipids on hydrolysis of trioleoylglycerol by human serum carboxylesterase.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11587492

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Analysis of nonlinear and nonsteady state hepatic extraction with the dispersion model using the finite difference method.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11587492

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prediction of adriamycin disposition in cancer patients using a physiologic, pharmacokinetic model

1 reference

https://pubmed.ncbi.nlm.nih.gov/11587492

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of food on the pharmacokinetics of capecitabine and its metabolites following oral administration in cancer patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/11587492

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

X-ray irradiation induces thymidine phosphorylase and enhances the efficacy of capecitabine (Xeloda) in human cancer xenografts

1 reference

https://pubmed.ncbi.nlm.nih.gov/11587492

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A review of metabolite kinetics

1 reference

https://pubmed.ncbi.nlm.nih.gov/11587492

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antitumor activities of a novel fluoropyrimidine, N4-pentyloxycarbonyl-5'-deoxy-5-fluorocytidine (capecitabine)

1 reference

https://pubmed.ncbi.nlm.nih.gov/11587492

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interspecies variation in liver weight, hepatic blood flow, and antipyrine intrinsic clearance: Extrapolation of data to benzodiazepines and phenytoin

1 reference

https://pubmed.ncbi.nlm.nih.gov/11587492

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Preferential activation of capecitabine in tumor following oral administration to colorectal cancer patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/11587492

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression levels of thymidine phosphorylase and dihydropyrimidine dehydrogenase in various human tumor tissues

1 reference

https://pubmed.ncbi.nlm.nih.gov/11587492

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vitro and in vivo evaluation of the tissue-to-blood partition coefficient for physiological pharmacokinetic models

1 reference

https://pubmed.ncbi.nlm.nih.gov/11587492

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hepatic and intestinal metabolism of indinavir, an HIV protease inhibitor, in rat and human microsomes. Major role of CYP3A

1 reference

https://pubmed.ncbi.nlm.nih.gov/11587492

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phase I and pharmacokinetic study of the oral fluoropyrimidine capecitabine in combination with paclitaxel in patients with advanced solid malignancies

1 reference

https://pubmed.ncbi.nlm.nih.gov/11587492

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1023/A:1010939329562

1 reference

Europe PubMed Central

PubMed publication ID

26 November 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

26 November 2017

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