(Q43814130)

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Inhibitors of trypsin-like serine proteases prevent DNA damage-induced neuronal death by acting upstream of the mitochondrial checkpoint and of p53 induction.

scientific article published in January 2001

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4 December 2019

Inhibitors of trypsin-like serine proteases prevent DNA damage-induced neuronal death by acting upstream of the mitochondrial checkpoint and of p53 induction (English)

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4 December 2019

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4 December 2019

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H J Rideout

1

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4 December 2019

E Zang

2

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4 December 2019

M Yeasmin

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4 December 2019

R Gordon

4

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4 December 2019

O Jabado

5

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4 December 2019

L Stefanis

7

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4 December 2019

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publication date

1 January 2001

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4 December 2019

1 reference

Europe PubMed Central

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4 December 2019

107

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4 December 2019

2

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4 December 2019

339-352

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4 December 2019

A role for MAPK/ERK in sympathetic neuron survival: protection against a p53-dependent, JNK-independent induction of apoptosis by cytosine arabinoside.

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Regulation of p53 stability and activity in response to genotoxic stress.

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Serine protease inhibitors suppress cytochrome c-mediatedcaspase-9 activation and apoptosis during hypoxia-reoxygenation

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ICE-LAP6, a novel member of the ICE/Ced-3 gene family, is activated by the cytotoxic T cell protease granzyme B

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The central executioners of apoptosis: caspases or mitochondria?

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Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor

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Proteasomes play an essential role in thymocyte apoptosis

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Neuroprotection by brain-derived neurotrophic factor is mediated by extracellular signal-regulated kinase and phosphatidylinositol 3-kinase.

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Contribution of p53-dependent caspase activation to neuronal cell death declines with neuronal maturation.

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A functional role for death proteases in s-Myc- and c-Myc-mediated apoptosis

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7 January 2021

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Involvement of caspase 3 in apoptotic death of cortical neurons evoked by DNA damage.

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How proteolysis drives the cell cycle

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Involvement of both caspase-like proteases and serine proteases in apoptotic cell death induced by ricin, modeccin, diphtheria toxin, and pseudomonas toxin

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Properties of three proteinases functioning at G1, S and G2 phases in HeLa cells and their inhibition by guanidino- and amidino-acid esters

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Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice

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Poly(ADP-ribose) polymerase activation mediates 1-methyl-4-phenyl-1, 2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism

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Biochemical characterization of programmed cell death in NGF-deprived sympathetic neurons.

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Cytofluorometric detection of mitochondrial alterations in early CD95/Fas/APO-1-triggered apoptosis of Jurkat T lymphoma cells. Comparison of seven mitochondrion-specific fluorochromes

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The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

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Optimization of single-cell gel electrophoresis (SCGE) for quantitative analysis of neuronal DNA damage

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Induction of neuronal apoptosis by camptothecin, an inhibitor of DNA topoisomerase-I: evidence for cell cycle-independent toxicity

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Cyclin-dependent kinases and P53 pathways are activated independently and mediate Bax activation in neurons after DNA damage.

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G1/S cell cycle blockers and inhibitors of cyclin-dependent kinases suppress camptothecin-induced neuronal apoptosis

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Inhibitors of trypsin-like serine proteases inhibit processing of the caspase Nedd-2 and protect PC12 cells and sympathetic neurons from death evoked by withdrawal of trophic support

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Caspase-2 (Nedd-2) processing and death of trophic factor-deprived PC12 cells and sympathetic neurons occur independently of caspase-3 (CPP32)-like activity

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Nedd2 is required for apoptosis after trophic factor withdrawal, but not superoxide dismutase (SOD1) downregulation, in sympathetic neurons and PC12 cells

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Identifiers

10.1016/S0306-4522(01)00322-0

1 reference

Europe PubMed Central

PubMed publication ID

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4 December 2019

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

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4 December 2019

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