(Q43823449)

English

The neuroprotective actions of FK506 binding protein ligands: neuronal survival is triggered by de novo RNA synthesis, but is independent of inhibition of JNK and calcineurin.

scientific article published in December 2001

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11744159%20AND%20SRC:MED&resulttype=core&format=json

4 December 2019

The neuroprotective actions of FK506 binding protein ligands: neuronal survival is triggered by de novo RNA synthesis, but is independent of inhibition of JNK and calcineurin (English)

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4 December 2019

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4 December 2019

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A Klettner

1

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4 December 2019

Y Zhang

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4 December 2019

G Fischer

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4 December 2019

E Bürger

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4 December 2019

T Herdegen

6

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4 December 2019

K Mielke

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4 December 2019

publication date

1 December 2001

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4 December 2019

Molecular Brain Research

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4 December 2019

97

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4 December 2019

1

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4 December 2019

21-31

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4 December 2019

Calcineurin and mitochondrial function in glutamate-induced neuronal cell death.

1 reference

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7 January 2021

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Ca2+/calcineurin-inhibited adenylyl cyclase, highly abundant in forebrain regions, is important for learning and memory.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-328X%2801%2900286-8

7 January 2021

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Design, synthesis and structure of non-macrocyclic inhibitors of FKBP12, the major binding protein for the immunosuppressant FK506.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-328X%2801%2900286-8

7 January 2021

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Induction of thymocyte apoptosis by Ca2+-independent protein kinase C (nPKC) activation and its regulation by calcineurin activation

1 reference

https://api.crossref.org/works/10.1016%2FS0169-328X%2801%2900286-8

7 January 2021

based on heuristic

inferred from DOI database lookup

High level calcineurin activity predisposes neuronal cells to apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0169-328X%2801%2900286-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Modulation of neurite branching by protein phosphorylation in cultured rat hippocampal neurons.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-328X%2801%2900286-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Co-stimulation-dependent activation of a JNK-kinase in T lymphocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0169-328X%2801%2900286-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Overexpression of glutathione peroxidase increases the resistance of neuronal cells to Abeta-mediated neurotoxicity

1 reference

https://api.crossref.org/works/10.1016%2FS0169-328X%2801%2900286-8

7 January 2021

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Ischemic preconditioning and brain tolerance: temporal histological and functional outcomes, protein synthesis requirement, and interleukin-1 receptor antagonist and early gene expression

1 reference

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7 January 2021

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Increased 3-nitrotyrosine in both sporadic and familial amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS0169-328X%2801%2900286-8

7 January 2021

based on heuristic

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Hydrogen peroxide mediates amyloid beta protein toxicity

1 reference

https://api.crossref.org/works/10.1016%2FS0169-328X%2801%2900286-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Repetitive electroconvulsive seizures induce activity of c-Jun N-terminal kinase and compartment-specific desensitization of c-Jun phosphorylation in the rat brain.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-328X%2801%2900286-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Nuclear accumulation of NFAT4 opposed by the JNK signal transduction pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0169-328X%2801%2900286-8

7 January 2021

based on heuristic

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Dual roles for c-Jun N-terminal kinase in developmental and stress responses in cerebellar granule neurons.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-328X%2801%2900286-8

7 January 2021

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A novel immunophilin ligand: distinct branching effects on dopaminergic neurons in culture and neurotrophic actions after oral administration in an animal model of Parkinson's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-328X%2801%2900286-8

7 January 2021

based on heuristic

inferred from DOI database lookup

c-Jun functions as a calcium-regulated transcriptional activator in the absence of JNK/SAPK1 activation.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-328X%2801%2900286-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Immunosuppressant FK506 enhances phosphorylation of nitric oxide synthase and protects against glutamate neurotoxicity

1 reference

https://api.crossref.org/works/10.1016%2FS0169-328X%2801%2900286-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Calcineurin promotes protein kinase C and c-Jun NH2-terminal kinase activation in the heart. Cross-talk between cardiac hypertrophic signaling pathways

1 reference

https://api.crossref.org/works/10.1016%2FS0169-328X%2801%2900286-8

7 January 2021

based on heuristic

inferred from DOI database lookup

ARNT2, a transcription factor for brain neuron survival?

1 reference

https://api.crossref.org/works/10.1016%2FS0169-328X%2801%2900286-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Specific inhibition of calcineurin by type II synthetic pyrethroid insecticides

1 reference

https://api.crossref.org/works/10.1016%2FS0169-328X%2801%2900286-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Class II pyrethroids: noninhibitors calcineurin.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-328X%2801%2900286-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Pyrethroid insecticides as phosphatase inhibitors.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-328X%2801%2900286-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Cyclophilin and peptidyl-prolyl cis-trans isomerase are probably identical proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0169-328X%2801%2900286-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Calcineurin phosphatase activity in T lymphocytes is inhibited by FK 506 and cyclosporin A

1 reference

https://api.crossref.org/works/10.1016%2FS0169-328X%2801%2900286-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Peptidylproline cis/trans isomerases

1 reference

https://api.crossref.org/works/10.1016%2FS0169-328X%2801%2900286-8

7 January 2021

based on heuristic

inferred from DOI database lookup

FK506 and the role of immunophilins in nerve regeneration

1 reference

https://api.crossref.org/works/10.1016%2FS0169-328X%2801%2900286-8

7 January 2021

based on heuristic

inferred from DOI database lookup

The immunosuppressant FK506 increases the rate of axonal regeneration in rat sciatic nerve

1 reference

https://api.crossref.org/works/10.1016%2FS0169-328X%2801%2900286-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Oral administration of a nonimmunosuppressant FKBP-12 ligand speeds nerve regeneration

1 reference

https://api.crossref.org/works/10.1016%2FS0169-328X%2801%2900286-8

7 January 2021

based on heuristic

inferred from DOI database lookup

A nonimmunosuppressant FKBP-12 ligand increases nerve regeneration.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-328X%2801%2900286-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Tyrosine kinase inhibitors and cycloheximide inhibit Li+ protection of cerebellar granule neurons switched to non-depolarizing medium.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-328X%2801%2900286-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Calcineurin Controls the Expression of Isoform 4CII of the Plasma Membrane Ca2+Pump in Neurons

1 reference

https://api.crossref.org/works/10.1016%2FS0169-328X%2801%2900286-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Immunophilin ligands as a novel treatment of neurological disorders

1 reference

https://api.crossref.org/works/10.1016%2FS0169-328X%2801%2900286-8

7 January 2021

based on heuristic

inferred from DOI database lookup

AP-1 proteins in the adult brain: facts and fiction about effectors of neuroprotection and neurodegeneration

1 reference

https://api.crossref.org/works/10.1016%2FS0169-328X%2801%2900286-8

7 January 2021

based on heuristic

inferred from DOI database lookup

The 25-kDa FK506-binding protein is localized in the nucleus and associates with casein kinase II and nucleolin

1 reference

https://api.crossref.org/works/10.1016%2FS0169-328X%2801%2900286-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Nerve growth factor and forskolin prevent H2O2-induced apoptosis in PC12 cells by glutathione independent mechanism

1 reference

https://api.crossref.org/works/10.1016%2FS0169-328X%2801%2900286-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Stimulation of expression for the adenosine A2A receptor gene by hypoxia in PC12 cells. A potential role in cell protection

1 reference

https://api.crossref.org/works/10.1016%2FS0169-328X%2801%2900286-8

7 January 2021

based on heuristic

inferred from DOI database lookup

The Jnk1 and Jnk2 protein kinases are required for regional specific apoptosis during early brain development.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-328X%2801%2900286-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Regulation of calcineurin by growth cone calcium waves controls neurite extension.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-328X%2801%2900286-8

7 January 2021

based on heuristic

inferred from DOI database lookup

High constitutive NF-kappaB activity mediates resistance to oxidative stress in neuronal cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-328X%2801%2900286-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Signal transduction mechanisms involved in ischemic preconditioning in the rat retina in vivo.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-328X%2801%2900286-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Inhibition of T cell signaling by immunophilin-ligand complexes correlates with loss of calcineurin phosphatase activity

1 reference

https://api.crossref.org/works/10.1016%2FS0169-328X%2801%2900286-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Tacrolimus (FK506) increases neuronal expression of GAP-43 and improves functional recovery after spinal cord injury in rats

1 reference

https://api.crossref.org/works/10.1016%2FS0169-328X%2801%2900286-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Calcineurin enhances MEF2 DNA binding activity in calcium-dependent survival of cerebellar granule neurons

1 reference

https://api.crossref.org/works/10.1016%2FS0169-328X%2801%2900286-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Rapid and long-lasting suppression of the ATF-2 transcription factor is a common response to neuronal injury

1 reference

https://api.crossref.org/works/10.1016%2FS0169-328X%2801%2900286-8

7 January 2021

based on heuristic

inferred from DOI database lookup

The tumor suppressor p53 can both stimulate and inhibit ultraviolet light-induced apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0169-328X%2801%2900286-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Selective expression of JNK isoforms and stress-specific JNK activity in different neural cell lines

1 reference

https://api.crossref.org/works/10.1016%2FS0169-328X%2801%2900286-8

7 January 2021

based on heuristic

inferred from DOI database lookup

JNK and p38 stresskinases--degenerative effectors of signal-transduction-cascades in the nervous system

1 reference

https://api.crossref.org/works/10.1016%2FS0169-328X%2801%2900286-8

7 January 2021

based on heuristic

inferred from DOI database lookup

FK506 augments glucocorticoid-mediated cyclooxygenase-2 down-regulation in human rheumatoid synovial fibroblasts.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-328X%2801%2900286-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Potential role of calcineurin for brain ischemia and traumatic injury

1 reference

https://api.crossref.org/works/10.1016%2FS0169-328X%2801%2900286-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Bcl-2 prevents caspase-independent cell death

1 reference

https://api.crossref.org/works/10.1016%2FS0169-328X%2801%2900286-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Expression of c-fos, c-jun, and c-jun N-terminal kinase (JNK) in a developmental model of induced apoptotic death in neurons of the substantia nigra.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-328X%2801%2900286-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Rapamycin, but not FK506 and GPI-1046, increases neurite outgrowth in PC12 cells by inhibiting cell cycle progression

1 reference

https://api.crossref.org/works/10.1016%2FS0169-328X%2801%2900286-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Bcl-xL is an antiapoptotic regulator for postnatal CNS neurons.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-328X%2801%2900286-8

7 January 2021

based on heuristic

inferred from DOI database lookup

The Jun kinase/stress-activated protein kinase pathway functions to regulate DNA repair and inhibition of the pathway sensitizes tumor cells to cisplatin

1 reference

https://api.crossref.org/works/10.1016%2FS0169-328X%2801%2900286-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Arachidonic acid induces mobilization of calcium stores and c-jun gene expression: evidence that intracellular calcium release is associated with c-jun activation

1 reference

https://api.crossref.org/works/10.1016%2FS0169-328X%2801%2900286-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Nerve growth factor determines survival and death of PC12 cells by regulation of the bcl-x, bax, and caspase-3 genes

1 reference

https://api.crossref.org/works/10.1016%2FS0169-328X%2801%2900286-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Neural roles of immunophilins and their ligands

1 reference

https://api.crossref.org/works/10.1016%2FS0169-328X%2801%2900286-8

7 January 2021

based on heuristic

inferred from DOI database lookup

beta-Adrenergic pathway induces apoptosis through calcineurin activation in cardiac myocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0169-328X%2801%2900286-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Tacrolimus (FK506) ameliorates skilled motor deficits produced by middle cerebral artery occlusion in rats.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-328X%2801%2900286-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Immunophilins in the nervous system

1 reference

https://api.crossref.org/works/10.1016%2FS0169-328X%2801%2900286-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Potentiation of Progesterone Receptor-Mediated Transcription by the Immunosuppressant FK506

1 reference

https://api.crossref.org/works/10.1016%2FS0169-328X%2801%2900286-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Immunosuppressive and non-immunosuppressive immunophilin ligands improve H(2)O(2)-induced cell damage by increasing glutathione levels in NG108-15 cells

1 reference

https://api.crossref.org/works/10.1016%2FS0169-328X%2801%2900286-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Neuroprotective FK506 does not alter in vivo nitric oxide production during ischemia and early reperfusion in rats

1 reference

https://api.crossref.org/works/10.1016%2FS0169-328X%2801%2900286-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD

1 reference

https://api.crossref.org/works/10.1016%2FS0169-328X%2801%2900286-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Calcineurin preferentially synergizes with PKC-theta to activate JNK and IL-2 promoter in T lymphocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0169-328X%2801%2900286-8

7 January 2021

based on heuristic

inferred from DOI database lookup

The immunophilin ligand FK506, but not GPI-1046, protects against neuronal death and inhibits c-Jun expression in the substantia nigra pars compacta following transection of the rat medial forebrain bundle

1 reference

https://api.crossref.org/works/10.1016%2FS0169-328X%2801%2900286-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Dynamic regulation of c-Jun N-terminal kinase activity in mouse brain by environmental stimuli

1 reference

https://api.crossref.org/works/10.1016%2FS0169-328X%2801%2900286-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Activation of caspase-9 and -3 during H2O2-induced apoptosis of PC12 cells independent of ceramide formation

1 reference

https://api.crossref.org/works/10.1016%2FS0169-328X%2801%2900286-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene

1 reference

https://api.crossref.org/works/10.1016%2FS0169-328X%2801%2900286-8

7 January 2021

based on heuristic

inferred from DOI database lookup

FK506 antagonizes apoptosis and c-jun protein expression in neuronal cultures

1 reference

https://api.crossref.org/works/10.1016%2FS0169-328X%2801%2900286-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1016/S0169-328X(01)00286-8

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11744159%20AND%20SRC:MED&resulttype=core&format=json

4 December 2019

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11744159%20AND%20SRC:MED&resulttype=core&format=json

4 December 2019

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