(Q43854124)

27 November 2017

title

Induction of lacI mutations in Big Blue rats treated with tamoxifen and alpha-hydroxytamoxifen (English)

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27 November 2017

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4

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27 November 2017

author name string

Gonçalo Gamboa da Costa

series ordinal

1

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27 November 2017

Mugimane G Manjanatha

series ordinal

2

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27 November 2017

M Matilde Marques

series ordinal

3

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27 November 2017

language of work or name

English

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publication date

1 February 2002

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27 November 2017

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27 November 2017

volume

176

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27 November 2017

issue

1

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27 November 2017

page(s)

37-45

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Tamoxifen for early breast cancer: an overview of the randomised trials. Early Breast Cancer Trialists' Collaborative Group

27 November 2017

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Understanding the genotoxicity of tamoxifen?

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Tamoxifen-DNA adducts detected in the endometrium of women treated with tamoxifen.

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Identification of tamoxifen-DNA adducts in the endometrium of women treated with tamoxifen.

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Lack of evidence from HPLC 32P-post-labelling for tamoxifenDNA adducts in the human endometrium

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The triphenylethylene drug tamoxifen is a strong liver carcinogen in the rat.

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DNA binding of tamoxifen and its analogues: identification of the tamoxifen-DNA adducts in rat liver

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Identification of the major tamoxifen-DNA adducts in rat liver by mass spectroscopy.

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N-Demethylation accompanies α-hydroxylation in the metabolic activation of tamoxifen in rat liver cells

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7 January 2021

Further characterization of the DNA adducts formed in rat liver after the administration of tamoxifen, N-desmethyltamoxifen or N, N-didesmethyltamoxifen

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Characterization of the Major DNA Adduct Formed by α-Hydroxy-N-desmethyltamoxifen in Vitro and in Vivo

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7 January 2021

DNA adduct formation and mutant induction in Sprague-Dawley rats treated with tamoxifen and its derivatives

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Mutational spectra of tamoxifen-induced mutations in the livers of lacI transgenic rats.

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Tamoxifen induces G:C-->T:A mutations in the cII gene in the liver of lambda/lacI transgenic rats but not at 5'-CpG-3' dinucleotide sequences as found in the lacI transgene.

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7 January 2021

Tamoxifen mutagenesis and carcinogenesis in livers of lambda/lacI transgenic rats: selective influence of phenobarbital promotion

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7 January 2021

Short-term dosing of alpha-hydroxytamoxifen results in DNA damage but does not lead to liver tumours in female Wistar/Han rats

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Uterine carcinoma in mice treated neonatally with tamoxifen

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Tamoxifen induces endometrial and vaginal cancer in rats in the absence of endometrial hyperplasia

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Determination of DNA damage in F344 rats induced by geometric isomers of tamoxifen and analogues

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Comparison of the DNA adducts formed by tamoxifen and 4-hydroxytamoxifen in vivo.

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Production of 8-hydroxy-2'-deoxguanosine in DNA by microsomal activation of tamoxifen and 4-hydroxytamoxifen

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DNA cleavage and 8-hydroxydeoxyguanosine formation caused by tamoxifen derivatives in vitro

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7 January 2021

Hydroxy derivatives of tamoxifen

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7 January 2021

Induction of 6-thioguanine-resistant lymphocytes in Fischer 344 rats following in vivo exposure to N-ethyl-N-nitrosourea and cyclophosphamide.

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7 January 2021

The effect of time after treatment, treatment schedule and animal age on the frequency of 6-thioguanine-resistant T-lymphocytes induced in Fischer 344 rats by N-ethyl-N-nitrosourea.

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7 January 2021

7,12-dimethylbenz[a]anthracene-induced mutation in the Tk gene of Tk(+/-) mice: automated scoring of lymphocyte clones using a fluorescent viability indicator.

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7 January 2021

DNA adduct formation and molecular analysis of in vivo lacI mutations in the mammary tissue of Big Blue rats treated with 7, 12-dimethylbenz[a]anthracene.

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7 January 2021

Nuclease P1-mediated enhancement of sensitivity of 32P-postlabeling test for structurally diverse DNA adducts.

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7 January 2021

Genotoxic potential of tamoxifen and analogues in female Fischer F344/n rats, DBA/2 and C57BL/6 mice and in human MCL-5 cells

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7 January 2021

Comparison of hprt and lacI mutant frequency with DNA adduct formation in N-hydroxy-2-acetylaminofluorene-treated Big Blue rats

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7 January 2021

10.1016/S0304-3835(01)00741-8

Identifiers

DOI

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27 November 2017

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