(Q43869059)

English

Synthesis and enzymatic activation of N-[N(alpha)-(4-amino-4-deoxypteroyl)-N(delta)-hemiphthaloyl-L-ornithiny]-L-phenylalanine, a candidate for antibody-directed enzyme prodrug therapy (ADEPT).

scientific article published in March 2002

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scholarly article

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Europe PubMed Central

PubMed publication ID

27 November 2017

Synthesis and enzymatic activation of N-[N(alpha)-(4-amino-4-deoxypteroyl)-N(delta)-hemiphthaloyl-L-ornithiny]-L-phenylalanine, a candidate for antibody-directed enzyme prodrug therapy (ADEPT). (English)

1 reference

Europe PubMed Central

PubMed publication ID

27 November 2017

author name string

Joel E Wright

1

1 reference

Europe PubMed Central

PubMed publication ID

27 November 2017

Andre Rosowsky

2

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Europe PubMed Central

PubMed publication ID

27 November 2017

language of work or name

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publication date

1 March 2002

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Europe PubMed Central

PubMed publication ID

27 November 2017

Bioorganic & Medicinal Chemistry

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Europe PubMed Central

PubMed publication ID

27 November 2017

10

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Europe PubMed Central

PubMed publication ID

27 November 2017

3

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Europe PubMed Central

PubMed publication ID

27 November 2017

493-500

1 reference

Europe PubMed Central

PubMed publication ID

27 November 2017

Antibody-directed enzyme prodrug therapy (ADEPT).

1 reference

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Generation of cytotoxic agents by targeted enzymes

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New approaches to antibody therapy

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Multiple event activation of a generic prodrug trigger by antibody catalysis

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Toward antibody-directed "abzyme" prodrug therapy, ADAPT: carbamate prodrug activation by a catalytic antibody and its in vitro application to human tumor cell killing

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Catalytic activity of an in vivo tumor targeted anti-CEA scFv::carboxypeptidase G2 fusion protein

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The effect of side-chain, para-aminobenzoyl region, and B-ring modifications on dihydrofolate reductase binding, influx via the reduced folate carrier, and cytotoxicity of the potent nonpolyglutamatable antifolate N(alpha)-(4-amino-4-deoxypteroyl)-N

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Methotrexate analogues. 15. A methotrexate analogue designed for active-site-directed irreversible inactivation of dihydrofolate reductase

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Toward antibody-directed enzyme prodrug therapy with the T268G mutant of human carboxypeptidase A1 and novel in vivo stable prodrugs of methotrexate

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Antibody-directed enzyme prodrug therapy with the T268G mutant of human carboxypeptidase A1: in vitro and in vivo studies with prodrugs of methotrexate and the thymidylate synthase inhibitors GW1031 and GW1843.

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Biodistribution of an antibody-enzyme conjugate for antibody-directed enzyme prodrug therapy in nude mice bearing a human colon adenocarcinoma xenograft

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The Eugene M. Landis Award Lecture 1996. Delivery of molecular and cellular medicine to solid tumors

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Direct in vivo observation of 5-fluorouracil release from a prodrug in human tumors heterotransplanted in nude mice: a magnetic resonance study

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Pharmacokinetics, antifolate activity and tissue distribution of PT523 in SCC VII tumor-bearing mice

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Analogues of the potent nonpolyglutamatable antifolate N(alpha)-(4-amino-4-deoxypteroyl)-N(delta)-hemiphthaloyl-L-ornithine (PT523) with modifications in the side chain, p-aminobenzoyl moiety, or 9,10-bridge: synthesis and in vitro antitumor activit

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Synthesis and potent antifolate activity and cytotoxicity of B-ring deaza analogues of the nonpolyglutamatable dihydrofolate reductase inhibitor Nalpha-(4-amino-4-deoxypteroyl)-Ndelta-hemiphthaloyl- L-ornithine (PT523).

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Methotrexate analogues. 25. Chemical and biological studies on the gamma-tert-butyl esters of methotrexate and aminopterin.

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NMR solution structure of the antitumor compound PT523 and NADPH in the ternary complex with human dihydrofolate reductase

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ZONE BEHAVIOR OF ENZYMES : ILLUSTRATED BY THE EFFECT OF DISSOCIATION CONSTANT AND DILUTION ON THE SYSTEM CHOLINESTERASE-PHYSOSTIGMINE.

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Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors

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Identifiers

10.1016/S0968-0896(01)00298-X

1 reference

Europe PubMed Central

PubMed publication ID

27 November 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

27 November 2017

ResearchGate publication ID

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