(Q43885264)

27 November 2017

title

Gene expression analysis of mTOR pathway: association with human longevity (English)

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2

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6

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11

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Evelyna Derhovanessian

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Evelyna Derhovanessian

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27 November 2017

Joris Deelen

3

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Andrea Maier

Andrea B Maier

5

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Eline Slagboom

Pieternella E Slagboom

12

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Willemijn M. Passtoors

1

Willemijn M Passtoors

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27 November 2017

4

Ruud van der Breggen

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8

Diana van Heemst

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9

Anton J M de Craen

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David A Gunn

10

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publication date

23 November 2012

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27 November 2017

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27 November 2017

volume

12

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27 November 2017

issue

1

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page(s)

24-31

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Mammalian target of rapamycin complex 2 (mTORC2) negatively regulates Toll-like receptor 4-mediated inflammatory response via FoxO1.

27 November 2017

cites work

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Genome-wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited

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Hallmark features of immunosenescence are absent in familial longevity.

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Metformin inhibits mammalian target of rapamycin-dependent translation initiation in breast cancer cells

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Androgen Receptor Enhances p27 Degradation in Prostate Cancer Cells through Rapid and Selective TORC2 Activation.

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Long-term calorie restriction is highly effective in reducing the risk for atherosclerosis in humans

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mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)

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A global test for groups of genes: testing association with a clinical outcome

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Testing association of a pathway with survival using gene expression data

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An expanding role for mTOR in cancer

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Lipoprotein particle profiles mark familial and sporadic human longevity

21 January 2018

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Caloric restriction in humans

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Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling

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Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients

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Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway

21 January 2018

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Multiparameter flow cytometric analysis of CD4 and CD8 T cell subsets in young and old people

21 January 2018

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Muscle-specific deletion of rictor impairs insulin-stimulated glucose transport and enhances Basal glycogen synthase activity

21 January 2018

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Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity

21 January 2018

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mTOR signaling at a glance

21 January 2018

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mTORC1 inhibitors: is temsirolimus in renal cancer telling us how they really work?

21 January 2018

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Unlike insulin, amino acids stimulate p70S6K but not GSK-3 or glycogen synthase in human skeletal muscle

21 January 2018

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Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

21 January 2018

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Sirolimus in renal transplantation

21 January 2018

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A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance

21 January 2018

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Transcriptional profiling of human familial longevity indicates a role for ASF1A and IL7R

21 January 2018

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mTOR and the control of whole body metabolism

21 January 2018

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PLINK: a tool set for whole-genome association and population-based linkage analyses

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Human insulin/IGF-1 and familial longevity at middle age.

21 January 2018

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Favorable glucose tolerance and lower prevalence of metabolic syndrome in offspring without diabetes mellitus of nonagenarian siblings: the Leiden longevity study

21 January 2018

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Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12015

Regulation of the mTOR complex 1 pathway by nutrients, growth factors, and stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12015

Rictor/TORC2 regulates fat metabolism, feeding, growth, and life span in Caenorhabditis elegans

21 January 2018

1 reference

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Rapid and reversible induction of the longevity, anticancer and genomic effects of caloric restriction

21 January 2018

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The TOR pathway comes of age

21 January 2018

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Pancreatic cancer: from molecular pathogenesis to targeted therapy

21 January 2018

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PRAS40 and PRR5-like protein are new mTOR interactors that regulate apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12015

Genetics: influence of TOR kinase on lifespan in C. elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12015

Nonagenarian siblings and their offspring display lower risk of mortality and morbidity than sporadic nonagenarians: The Leiden Longevity Study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12015

Familial longevity is marked by enhanced insulin sensitivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12015

Targeting the PI3K-AKT-mTOR pathway: progress, pitfalls, and promises

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12015

21 January 2018

Identifiers

DOI

10.1111/ACEL.12015

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27 November 2017

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