(Q43932822)

28 November 2017

Amodiaquine metabolism is impaired by common polymorphisms in CYP2C8: implications for malaria treatment in Africa (English)

1 reference

28 November 2017

0 references

0 references

S Parikh

1

1 reference

28 November 2017

J-B Ouedraogo

2

1 reference

28 November 2017

J A Goldstein

3

1 reference

28 November 2017

P J Rosenthal

4

1 reference

28 November 2017

D L Kroetz

5

1 reference

28 November 2017

language of work or name

English

0 references

publication date

14 March 2007

1 reference

Clinical Pharmacology & Therapeutics

28 November 2017

1 reference

28 November 2017

82

1 reference

28 November 2017

197-203

1 reference

28 November 2017

2

1 reference

https://scigraph.springernature.com/pub.10.1038/sj.clpt.6100122

28 November 2017

0 references

cites work

The disposition of amodiaquine in man after oral administration

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100122

Pharmacokinetics of intravenous amodiaquine

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100122

Amodiaquine-induced hepatitis. A report of seven cases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100122

The toxicity of amodiaquine and its principal metabolites towards mononuclear leucocytes and granulocyte/monocyte colony forming units

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100122

Effect of monodesethyl amodiaquine on human polymorphonuclear neutrophil functions in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100122

Detection of antidrug IgG antibodies in patients with adverse drug reactions to amodiaquine

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100122

Global and regional burden of disease and risk factors, 2001: systematic analysis of population health data

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100122

7 January 2021

Conquering the intolerable burden of malaria: what's new, what's needed: a summary.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100122

7 January 2021

The global distribution of clinical episodes of Plasmodium falciparum malaria

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100122

7 January 2021

Serious adverse drug reactions to pyrimethamine-sulphadoxine, pyrimethamine-dapsone and to amodiaquine in Britain.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100122

7 January 2021

Frequency of severe neutropenia associated with amodiaquine prophylaxis against malaria.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100122

7 January 2021

Fatal acute hepatitis due to amodiaquine.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100122

7 January 2021

Systematic review of amodiaquine treatment in uncomplicated malaria

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100122

7 January 2021

Amodiaquine clearance and its metabolism to N-desethylamodiaquine is mediated by CYP2C8: a new high affinity and turnover enzyme-specific probe substrate

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100122

7 January 2021

Identification of human cytochrome P(450)s that metabolise anti-parasitic drugs and predictions of in vivo drug hepatic clearance from in vitro data

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100122

7 January 2021

Cytochrome P450 2C8: substrates, inhibitors, pharmacogenetics, and clinical relevance

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100122

7 January 2021

Polymorphisms in human CYP2C8 decrease metabolism of the anticancer drug paclitaxel and arachidonic acid.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100122

7 January 2021

Functional characterization of five novel CYP2C8 variants, G171S, R186X, R186G, K247R, and K383N, found in a Japanese population.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100122

7 January 2021

Five novel single nucleotide polymorphisms in the CYP2C8 gene, one of which induces a frame-shift.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100122

7 January 2021

CYP2C8 polymorphism frequencies among malaria patients in Zanzibar.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100122

7 January 2021

Short communication: high prevalence of the cytochrome P450 2C8*2 mutation in Northern Ghana

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100122

7 January 2021

CYP2C8 polymorphism among the Portuguese

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100122

7 January 2021

CYP2C8 polymorphisms in Caucasians and their relationship with paclitaxel 6α-hydroxylase activity in human liver microsomes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100122

7 January 2021

Linkage between the CYP2C8 and CYP2C9 genetic polymorphisms

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100122

7 January 2021

Genetic polymorphism of CYP2C8 in three Malaysian ethnics: CYP2C8*2 and CYP2C8*3 are found in Malaysian Indians.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100122

7 January 2021

Genetic polymorphisms of CYP2C8 in Japanese population.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100122

7 January 2021

Amodiaquine, sulfadoxine-pyrimethamine, and combination therapy for uncomplicated falciparum malaria: a randomized controlled trial from Burkina Faso.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100122

7 January 2021

Isolation, characterization and standardization of a major metabolite of amodiaquine by chromatographic and spectroscopic methods

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100122

7 January 2021

Sensitive analysis of blood for amodiaquine and three metabolites by high-performance liquid chromatography with electrochemical detection

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100122

7 January 2021

Role of hepatic metabolism in the bioactivation and detoxication of amodiaquine

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100122

7 January 2021

Rifampin reduces concentrations of trimethoprim and sulfamethoxazole in serum in human immunodeficiency virus-infected patients

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100122

7 January 2021

Pharmacokinetics of sequential and simultaneous treatment with the combination chloroquine and sulfadoxine-pyrimethamine in acute uncomplicated Plasmodium falciparum malaria in the Philippines

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100122

7 January 2021

The steady-state pharmacokinetics of nevirapine during once daily and twice daily dosing in HIV-1-infected individuals

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100122

7 January 2021

Examination of 209 drugs for inhibition of cytochrome P450 2C8

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100122

7 January 2021

Trimethoprim and sulfamethoxazole are selective inhibitors of CYP2C8 and CYP2C9, respectively

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100122

7 January 2021

The effect of the cytochrome P450 CYP2C8 polymorphism on the disposition of (R)-ibuprofen enantiomer in healthy subjects.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100122

7 January 2021

Disposition of monodesethylamodiaquine after a single oral dose of amodiaquine and three regimens for prophylaxis against Plasmodium falciparum malaria.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100122

7 January 2021

Amodiaquine as a prodrug: importance of metabolite(s) in the antimalarial effect of amodiaquine in humans

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100122

7 January 2021

Amodiaquine induced agranulocytosis and liver damage.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100122

7 January 2021

The in vitro effect of amodiaquine on bone marrow granulocyte-macrophage progenitor cells from normal subjects

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100122

7 January 2021

Amodiaquine induced agranulocytosis: inhibition of colony growth in bone marrow by antimalarial agents

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100122

7 January 2021

Mechanisms of the formation and disposition of reactive metabolites that can cause acute liver injury.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100122

7 January 2021

Autoxidative formation of a chemically reactive intermediate from amodiaquine, a myelotoxin and hepatotoxin in man.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100122

7 January 2021

Drug-protein conjugates--XVIII. Detection of antibodies towards the antimalarial amodiaquine and its quinone imine metabolite in man and the rat.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100122

7 January 2021

Amodiaquine-induced immune agranulocytosis.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100122

7 January 2021

The bioactivation of amodiaquine by human polymorphonuclear leucocytes in vitro: Chemical mechanisms and the effects of fluorine substitution

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100122

7 January 2021

The mechanism of bioactivation and antigen formation of amodiaquine in the rat

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100122

7 January 2021

Cotrimoxazole prophylaxis by HIV-infected persons in Uganda reduces morbidity and mortality among HIV-uninfected family members

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100122

7 January 2021

Combination treatments for uncomplicated falciparum malaria in Kampala, Uganda: randomised clinical trial

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100122

7 January 2021

The HIV-AIDS pandemic at 25--the global response.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100122

7 January 2021

Identification of CYP3A4 and CYP2C8 as the major cytochrome P450 s responsible for morphine N-demethylation in human liver microsomes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100122

7 January 2021

Catalytic activity and isoform-specific inhibition of rat cytochrome p450 4F enzymes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100122

7 January 2021

Identifiers

DOI

10.1038/SJ.CLPT.6100122

1 reference

Dimensions Publication ID

28 November 2017

0 references

1 reference