(Q43942178)

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Evaluation of drugs acting at glutamate transporters in organotypic hippocampal cultures: new evidence on substrates and blockers in excitotoxicity

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Europe PubMed Central

PubMed publication ID

28 November 2017

Evaluation of drugs acting at glutamate transporters in organotypic hippocampal cultures: new evidence on substrates and blockers in excitotoxicity (English)

1 reference

Europe PubMed Central

PubMed publication ID

28 November 2017

1 reference

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Niels Christian Danbolt

5

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Europe PubMed Central

PubMed publication ID

28 November 2017

author name string

Ross D O'Shea

1

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Europe PubMed Central

PubMed publication ID

28 November 2017

Melissa V Fodera

2

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Europe PubMed Central

PubMed publication ID

28 November 2017

Karina Apricó

3

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Europe PubMed Central

PubMed publication ID

28 November 2017

Yvette Dehnes

4

1 reference

Europe PubMed Central

PubMed publication ID

28 November 2017

Duncan Crawford

6

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Europe PubMed Central

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28 November 2017

Philip M Beart

7

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Europe PubMed Central

PubMed publication ID

28 November 2017

language of work or name

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publication date

1 February 2002

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Europe PubMed Central

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28 November 2017

Neurochemical Research

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Europe PubMed Central

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28 November 2017

27

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Europe PubMed Central

PubMed publication ID

28 November 2017

1-2

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Europe PubMed Central

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28 November 2017

5-13

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Europe PubMed Central

PubMed publication ID

28 November 2017

A pharmacological review of competitive inhibitors and substrates of high-affinity, sodium-dependent glutamate transport in the central nervous system

1 reference

https://pubmed.ncbi.nlm.nih.gov/11926276

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Deficient glutamate transport is associated with neurodegeneration in Alzheimer's disease

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https://pubmed.ncbi.nlm.nih.gov/11926276

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Localization of transporters using transporter-specific antibodies

1 reference

https://pubmed.ncbi.nlm.nih.gov/11926276

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Heterogeneity and functional properties of subtypes of sodium-dependent glutamate transporters in the mammalian central nervous system.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11926276

12 December 2020

based on heuristic

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Long-term hippocampal slices: a model system for investigating synaptic mechanisms and pathologic processes

1 reference

https://pubmed.ncbi.nlm.nih.gov/11926276

12 December 2020

based on heuristic

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Knockout of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearance of glutamate

1 reference

https://pubmed.ncbi.nlm.nih.gov/11926276

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The glutamate transport inhibitor L-trans-pyrrolidine-2,4-dicarboxylate indirectly evokes NMDA receptor mediated neurotoxicity in rat cortical cultures

1 reference

https://pubmed.ncbi.nlm.nih.gov/11926276

12 December 2020

based on heuristic

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Chronic inhibition of glutamate uptake produces a model of slow neurotoxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/11926276

12 December 2020

based on heuristic

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Spontaneous pyramidal cell death in organotypic slice cultures from rat hippocampus is prevented by glutamate receptor antagonists

1 reference

https://pubmed.ncbi.nlm.nih.gov/11926276

12 December 2020

based on heuristic

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Strategies for studies of neurotoxic mechanisms involving deficient transport of L-glutamate: antisense knockout in rat brain in vivo and changes in the neurotransmitter metabolism following inhibition of glutamate transport in guinea pig brain slic

1 reference

https://pubmed.ncbi.nlm.nih.gov/11926276

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

2-(carboxycyclopropyl)glycines: binding, neurotoxicity and induction of intracellular free Ca2+ increase

1 reference

https://pubmed.ncbi.nlm.nih.gov/11926276

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glutamate uptake

1 reference

https://pubmed.ncbi.nlm.nih.gov/11926276

12 December 2020

based on heuristic

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A novel kainate receptor ligand [3H]-(2S,4R)-4-methylglutamate: pharmacological characterization in rabbit brain membranes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11926276

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regional distribution of low affinity kainate receptors in brain of Macaca fascicularis determined by autoradiography using [3H](2S,4R)-4-methylglutamate

1 reference

https://pubmed.ncbi.nlm.nih.gov/11926276

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acute neurotoxicity of L-glutamate induced by impairment of the glutamate uptake system

1 reference

https://pubmed.ncbi.nlm.nih.gov/11926276

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of uptake unmasks rapid extracellular turnover of glutamate of nonvesicular origin.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11926276

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transporter reversal as a mechanism of glutamate release from the ischemic rat cerebral cortex: studies with DL-threo-beta-benzyloxyaspartate

1 reference

https://pubmed.ncbi.nlm.nih.gov/11926276

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Subtypes of sodium-dependent high-affinity L-[3H]glutamate transport activity: pharmacologic specificity and regulation by sodium and potassium.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11926276

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytotoxic effects of kainate ligands on HEK cell lines expressing recombinant kainate receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/11926276

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glutamate toxicity in neuron-enriched and neuron-astrocyte co-cultures: effect of the glutamate uptake inhibitor L-trans-pyrrolidine-2,4-dicarboxylate

1 reference

https://pubmed.ncbi.nlm.nih.gov/11926276

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glia modulate the response of murine cortical neurons to excitotoxicity: glia exacerbate AMPA neurotoxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/11926276

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence that reversed glutamate uptake contributes significantly to glutamate release following experimental injury to the rat spinal cord

1 reference

https://pubmed.ncbi.nlm.nih.gov/11926276

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The competitive transport inhibitor L-trans-pyrrolidine-2, 4-dicarboxylate triggers excitotoxicity in rat cortical neuron-astrocyte co-cultures via glutamate release rather than uptake inhibition.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11926276

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Astrocytes: glutamate producers for neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/11926276

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glutamate induces rapid upregulation of astrocyte glutamate transport and cell-surface expression of GLAST.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11926276

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Markers for neuronal degeneration in organotypic slice cultures

1 reference

https://pubmed.ncbi.nlm.nih.gov/11926276

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DL-threo-beta-benzyloxyaspartate, a potent blocker of excitatory amino acid transporters

1 reference

https://pubmed.ncbi.nlm.nih.gov/11926276

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glutamate receptor agonists up-regulate glutamate transporter GLAST in astrocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/11926276

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glutamate release in severe brain ischaemia is mainly by reversed uptake.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11926276

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurotoxicity of acute glutamate transport blockade depends on coactivation of both NMDA and AMPA/Kainate receptors in organotypic hippocampal cultures.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11926276

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High affinity glutamate transporters: regulation of expression and activity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11926276

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Excitatory amino acids as a final common pathway for neurologic disorders.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11926276

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glutamate transporter protein subtypes are expressed differentially during rat CNS development.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11926276

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quantitative determination of glutamate mediated cortical neuronal injury in cell culture by lactate dehydrogenase efflux assay

1 reference

https://pubmed.ncbi.nlm.nih.gov/11926276

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The log transformation is special

1 reference

https://pubmed.ncbi.nlm.nih.gov/11926276

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The high-affinity glutamate transporters GLT1, GLAST, and EAAT4 are regulated via different signalling mechanisms.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11926276

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Development of kainic acid and N-methyl-D-aspartic acid toxicity in organotypic hippocampal cultures.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11926276

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glutamate: A Neurotransmitter in Mammalian Brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/11926276

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Contrasting modes of action of methylglutamate derivatives on the excitatory amino acid transporters, EAAT1 and EAAT2.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11926276

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glutamate uptake disguises neurotoxic potency of glutamate agonists in cerebral cortex in dissociated cell culture

1 reference

https://pubmed.ncbi.nlm.nih.gov/11926276

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Local injection of kainic acid causes widespread degeneration of NADPH-d neurons and induction of NADPH-d in neurons, endothelial cells and reactive astrocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/11926276

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A simple method for organotypic cultures of nervous tissue

1 reference

https://pubmed.ncbi.nlm.nih.gov/11926276

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential expression of two glial glutamate transporters in the rat brain: quantitative and immunocytochemical observations

1 reference

https://pubmed.ncbi.nlm.nih.gov/11926276

12 December 2020

based on heuristic

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Cloned glutamate receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/11926276

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Developmental expression of excitatory amino acid transporter 5: a photoreceptor and bipolar cell glutamate transporter in rat retina

1 reference

https://pubmed.ncbi.nlm.nih.gov/11926276

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Kainate-induced apoptosis in cultured murine cerebellar granule cells elevates expression of the cell cycle gene cyclin D1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11926276

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

[(3)H](2S,4R)-4-Methylglutamate: a novel ligand for the characterization of glutamate transporters

1 reference

https://pubmed.ncbi.nlm.nih.gov/11926276

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of glutamate uptake induces progressive accumulation of extracellular glutamate and neuronal damage in rat cortical cultures

1 reference

https://pubmed.ncbi.nlm.nih.gov/11926276

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular pharmacology and physiology of glutamate transporters in the central nervous system

1 reference

https://pubmed.ncbi.nlm.nih.gov/11926276

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The methylglutamate, SYM 2081, is a potent and highly selective agonist at kainate receptors.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11926276

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular pharmacology of 4-substituted glutamic acid analogues at ionotropic and metabotropic excitatory amino acid receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/11926276

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of glutamate uptake with L-trans-pyrrolidine-2,4-dicarboxylate potentiates glutamate toxicity in primary hippocampal cultures

1 reference

https://pubmed.ncbi.nlm.nih.gov/11926276

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Excitatory and inhibitory pathways modulate kainate excitotoxicity in hippocampal slice cultures.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11926276

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cortical neurones exhibiting kainate-activated Co2+ uptake are selectively vulnerable to AMPA/kainate receptor-mediated toxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/11926276

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1023/A:1014813518604

1 reference

Europe PubMed Central

PubMed publication ID

28 November 2017

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PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

28 November 2017

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