(Q43955942)

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Ganciclovir-induced apoptosis in HSV-1 thymidine kinase expressing cells: critical role of DNA breaks, Bcl-2 decline and caspase-9 activation

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scholarly article

1 reference

Europe PubMed Central

28 November 2017

Ganciclovir-induced apoptosis in HSV-1 thymidine kinase expressing cells: critical role of DNA breaks, Bcl-2 decline and caspase-9 activation (English)

1 reference

Europe PubMed Central

28 November 2017

Herpes simplex virus type 1

1 reference

based on heuristic

inferred from title

apoptotic process

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based on heuristic

inferred from title

author name string

Maja T Tomicic

1

1 reference

Europe PubMed Central

28 November 2017

Rudolf Thust

2

1 reference

Europe PubMed Central

28 November 2017

Bernd Kaina

3

1 reference

Europe PubMed Central

28 November 2017

language of work or name

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publication date

1 March 2002

1 reference

Europe PubMed Central

28 November 2017

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Europe PubMed Central

28 November 2017

21

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Europe PubMed Central

28 November 2017

14

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Europe PubMed Central

28 November 2017

2141-2153

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Europe PubMed Central

28 November 2017

https://scigraph.springernature.com/pub.10.1038/sj.onc.1205280

0 references

Herpes simplex virus thymidine kinase/ganciclovir-induced apoptosis involves ligand-independent death receptor aggregation and activation of caspases.

1 reference

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21 January 2018

Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD-specific caspase activation and independently of mitochondrial transmembrane depolarization.

1 reference

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A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

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Conversion of Bcl-2 to a Bax-like death effector by caspases

1 reference

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Increased bax expression is associated with cell death induced by ganciclovir in a herpes thymidine kinase gene-expressing glioma cell line

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Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

1 reference

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Ultraviolet light-induced DNA damage triggers apoptosis in nucleotide excision repair-deficient cells via Bcl-2 decline and caspase-3/-8 activation

1 reference

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21 January 2018

Involvement of Bcl-2 cleavage in the acceleration of VP-16-induced U937 cell apoptosis.

1 reference

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Cumulative prognostic value of p53 mutations and bcl-2 protein expression in head-and-neck cancer treated by radiotherapy.

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Alphaviruses induce apoptosis in Bcl-2-overexpressing cells: evidence for a caspase-mediated, proteolytic inactivation of Bcl-2.

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Characterization of p53 in Chinese hamster cell lines CHO-K1, CHO-WBL, and CHL: implications for genotoxicity testing

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Quantitation of DNA fragmentation in apoptosis

1 reference

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The comet assay: mechanisms and technical considerations

1 reference

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Cloning and characterization of Chinese hamster p53 cDNA.

1 reference

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Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade

1 reference

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21 January 2018

DNA double-strand breaks trigger apoptosis in p53-deficient fibroblasts

1 reference

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21 January 2018

Bystander killing of cancer cells by herpes simplex virus thymidine kinase gene is mediated by connexins

1 reference

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p53 activates the CD95 (APO-1/Fas) gene in response to DNA damage by anticancer drugs

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A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry

1 reference

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Chromosomal aberrations induced by restriction endonucleases

1 reference

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Gene therapy for the treatment of brain tumors using intra-tumoral transduction with the thymidine kinase gene and intravenous ganciclovir

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21 January 2018

A UV-responsive G2 checkpoint in rodent cells

1 reference

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Radiation response of mouse lymphoid and myeloid cell lines. Part III. Different signals can lead to apoptosis and may influence sensitivity to killing by DNA double-strand breakage

1 reference

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21 January 2018

A caspase-9 variant missing the catalytic site is an endogenous inhibitor of apoptosis

1 reference

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Ordering the cytochrome c-initiated caspase cascade: hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner

1 reference

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Molecular ordering of the Fas-apoptotic pathway: the Fas/APO-1 protease Mch5 is a CrmA-inhibitable protease that activates multiple Ced-3/ICE-like cysteine proteases

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Distinct caspase cascades are initiated in receptor-mediated and chemical-induced apoptosis.

1 reference

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Comparison of the genotoxic and apoptosis-inducing properties of ganciclovir and penciclovir in Chinese hamster ovary cells transfected with the thymidine kinase gene of herpes simplex virus-1: implications for gene therapeutic approaches

1 reference

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Cytogenetic genotoxicity of anti-herpes purine nucleoside analogues in CHO cells expressing the thymidine kinase gene of herpes simplex virus type 1: comparison of ganciclovir, penciclovir and aciclovir

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21 January 2018

Cloning and functional analysis of cDNA encoding the hamster Bcl-2 protein

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Hamster Bcl-2 protein is cleaved in vitro and in cells by caspase-9 and caspase-3.

1 reference

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A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V

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S- and G2-phase cell cycle arrests and apoptosis induced by ganciclovir in murine melanoma cells transduced with herpes simplex virus thymidine kinase.

1 reference

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Involvement of Fas (CD95/APO-1) and Fas ligand in apoptosis induced by ganciclovir treatment of tumor cells transduced with herpes simplex virus thymidine kinase

1 reference

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Cytotoxic T-cell-derived granzyme B activates the apoptotic protease ICE-LAP3

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ICE-LAP6, a novel member of the ICE/Ced-3 gene family, is activated by the cytotoxic T cell protease granzyme B

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Expression of the apoptosis-related oncogenes bcl-2, bax, and p53 in Merkel cell carcinoma: can they predict treatment response and clinical outcome?

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Chromosomal instability, reproductive cell death and apoptosis induced by O6-methylguanine in Mex-, Mex+ and methylation-tolerant mismatch repair compromised cells: facts and models

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Caspase-3-dependent cleavage of Bcl-2 promotes release of cytochrome c

1 reference

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Expression of yeast but not human apurinic/apyrimidinic endonuclease renders Chinese hamster cells more resistant to DNA damaging agents

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Antiapoptotic action of 1,25-dihydroxyvitamin D3 is associated with increased mitochondrial MCL-1 and RAF-1 proteins and reduced release of cytochrome c

1 reference

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10.1038/SJ.ONC.1205280

1 reference

Europe PubMed Central

28 November 2017

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1 reference

Europe PubMed Central

28 November 2017

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