(Q43982351)

English

Inhibition of Src family kinases blocks epidermal growth factor (EGF)-induced activation of Akt, phosphorylation of c-Cbl, and ubiquitination of the EGF receptor

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scholarly article

1 reference

Europe PubMed Central

28 November 2017

Inhibition of Src family kinases blocks epidermal growth factor (EGF)-induced activation of Akt, phosphorylation of c-Cbl, and ubiquitination of the EGF receptor (English)

1 reference

Europe PubMed Central

28 November 2017

phosphorylation

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protein ubiquitination

1 reference

based on heuristic

inferred from title

author name string

C Kenneth Kassenbrock

1

1 reference

Europe PubMed Central

28 November 2017

Seija Hunter

2

1 reference

Europe PubMed Central

28 November 2017

Pamela Garl

3

1 reference

Europe PubMed Central

28 November 2017

Gary L Johnson

4

1 reference

Europe PubMed Central

28 November 2017

Steven M Anderson

5

1 reference

Europe PubMed Central

28 November 2017

language of work or name

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publication date

6 May 2002

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Europe PubMed Central

28 November 2017

Journal of Biological Chemistry

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Europe PubMed Central

28 November 2017

277

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Europe PubMed Central

28 November 2017

24967-24975

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Europe PubMed Central

28 November 2017

28

1 reference

Europe PubMed Central

28 November 2017

Cbl: complex formation and functional implications

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201026200

21 January 2018

Molecules in focus: The c-Cbl oncoprotein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201026200

21 January 2018

Adaptors and molecular scaffolds in immune cell signaling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201026200

21 January 2018

Similarity of sli-1, a regulator of vulval development in C. elegans, to the mammalian proto-oncogene c-cbl

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201026200

21 January 2018

Cbl: many adaptations to regulate protein tyrosine kinases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201026200

21 January 2018

p120cbl is a cytosolic adapter protein that associates with phosphoinositide 3-kinase in response to epidermal growth factor in PC12 and other cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201026200

21 January 2018

Tyrosine phosphorylation of Cbl upon epidermal growth factor (EGF) stimulation and its association with EGF receptor and downstream signaling proteins

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201026200

21 January 2018

Phosphorylation of Cbl following stimulation with interleukin-3 and its association with Grb2, Fyn, and phosphatidylinositol 3-kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201026200

21 January 2018

The proto-oncogene product p120(cbl) links c-Src and phosphatidylinositol 3'-kinase to the integrin signaling pathway.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201026200

21 January 2018

Differential signaling after beta1 integrin ligation is mediated through binding of CRKL to p120(CBL) and p110(HEF1)

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201026200

21 January 2018

The SH3 domain-binding T cell tyrosyl phosphoprotein p120. Demonstration of its identity with the c-cbl protooncogene product and in vivo complexes with Fyn, Grb2, and phosphatidylinositol 3-kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201026200

21 January 2018

p120cbl is a major substrate of tyrosine phosphorylation upon B cell antigen receptor stimulation and interacts in vivo with Fyn and Syk tyrosine kinases, Grb2 and Shc adaptors, and the p85 subunit of phosphatidylinositol 3-kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201026200

21 January 2018

Association of tyrosine protein kinase Zap-70 with the protooncogene product p120c-cbl in T lymphocytes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201026200

21 January 2018

Tyrosine phosphorylation of the c-cbl proto-oncogene protein product and association with epidermal growth factor (EGF) receptor upon EGF stimulation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201026200

21 January 2018

Fyn, Yes, and Syk phosphorylation sites in c-Cbl map to the same tyrosine residues that become phosphorylated in activated T cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201026200

21 January 2018

Characterization of Cbl tyrosine phosphorylation and a Cbl-Syk complex in RBL-2H3 cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201026200

21 January 2018

Coordinated regulation of the tyrosine phosphorylation of Cbl by Fyn and Syk tyrosine kinases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201026200

21 January 2018

c-Cbl is downstream of c-Src in a signalling pathway necessary for bone resorption.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201026200

21 January 2018

The proto-oncogene p120(Cbl) is a downstream substrate of the Hck protein-tyrosine kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201026200

21 January 2018

Cbl-mediated negative regulation of platelet-derived growth factor receptor-dependent cell proliferation. A critical role for Cbl tyrosine kinase-binding domain

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201026200

21 January 2018

The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201026200

21 January 2018

Ligand-induced ubiquitination of the epidermal growth factor receptor involves the interaction of the c-Cbl RING finger and UbcH7

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201026200

21 January 2018

Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201026200

21 January 2018

Fyn associates with Cbl and phosphorylates tyrosine 731 in Cbl, a binding site for phosphatidylinositol 3-kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201026200

21 January 2018

Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201026200

21 January 2018

The relationship between c-erbB-2 expression, S-phase fraction and prognosis in breast cancer

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201026200

21 January 2018

Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201026200

21 January 2018

Myc and Max proteins possess distinct transcriptional activities

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201026200

21 January 2018

Cellular survival: a play in three Akts

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201026200

21 January 2018

Regulation of neuronal survival by the serine-threonine protein kinase Akt

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201026200

21 January 2018

The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201026200

21 January 2018

Phosphoinositide 3-kinases: a conserved family of signal transducers

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201026200

21 January 2018

SH2 domains recognize specific phosphopeptide sequences

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201026200

21 January 2018

Crystal structure of Hck in complex with a Src family-selective tyrosine kinase inhibitor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201026200

21 January 2018

Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor. Study of Lck- and FynT-dependent T cell activation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201026200

21 January 2018

New role for Shc in activation of the phosphatidylinositol 3-kinase/Akt pathway

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201026200

21 January 2018

Structure of a c-Cbl-UbcH7 complex: RING domain function in ubiquitin-protein ligases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201026200

21 January 2018

Mechanism of biological synergy between cellular Src and epidermal growth factor receptor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201026200

21 January 2018

Src-catalyzed phosphorylation of c-Cbl leads to the interdependent ubiquitination of both proteins

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201026200

21 January 2018

Src family kinases negatively regulate platelet-derived growth factor alpha receptor-dependent signaling and disease progression

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201026200

21 January 2018

The orphan nuclear receptor SHP inhibits hepatocyte nuclear factor 4 and retinoid X receptor transactivation: two mechanisms for repression

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201026200

21 January 2018

TRANCE, a TNF family member, activates Akt/PKB through a signaling complex involving TRAF6 and c-Src

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201026200

21 January 2018

Selective requirement for Src kinases during VEGF-induced angiogenesis and vascular permeability

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201026200

21 January 2018

SU6656, a selective src family kinase inhibitor, used to probe growth factor signaling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201026200

21 January 2018

Tissue hyperplasia and enhanced T-cell signalling via ZAP-70 in c-Cbl-deficient mice

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201026200

21 January 2018

The non-receptor tyrosine kinase Syk is a target of Cbl-mediated ubiquitylation upon B-cell receptor stimulation.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201026200

21 January 2018

Proteolysis-independent regulation of PI3K by Cbl-b-mediated ubiquitination in T cells.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201026200

21 January 2018

Identifiers

10.1074/JBC.M201026200

1 reference

Europe PubMed Central

28 November 2017

1 reference

Europe PubMed Central

28 November 2017

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