(Q44022830)

English

10-Formyl-5,10-dideaza-acyclic-5,6,7,8-tetrahydrofolic acid (10-formyl-DDACTHF): a potent cytotoxic agent acting by selective inhibition of human GAR Tfase and the de novo purine biosynthetic pathway

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Europe PubMed Central

PubMed publication ID

29 November 2017

10-Formyl-5,10-dideaza-acyclic-5,6,7,8-tetrahydrofolic acid (10-formyl-DDACTHF): a potent cytotoxic agent acting by selective inhibition of human GAR Tfase and the de novo purine biosynthetic pathway (English)

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Europe PubMed Central

PubMed publication ID

29 November 2017

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Ian Andrew Wilson

11

object named as

Ian A Wilson

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Europe PubMed Central

PubMed publication ID

29 November 2017

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Thomas H Marsilje

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Europe PubMed Central

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29 November 2017

Marc A Labroli

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Europe PubMed Central

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29 November 2017

Michael P Hedrick

3

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29 November 2017

Qing Jin

4

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29 November 2017

Joel Desharnais

5

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29 November 2017

Stephen J Baker

6

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29 November 2017

Lata T Gooljarsingh

7

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29 November 2017

Joseph Ramcharan

8

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29 November 2017

Ali Tavassoli

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Europe PubMed Central

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29 November 2017

Yan Zhang

10

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29 November 2017

G Peter Beardsley

12

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29 November 2017

Stephen J Benkovic

13

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29 November 2017

Dale L Boger

14

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29 November 2017

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publication date

1 August 2002

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Europe PubMed Central

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29 November 2017

Bioorganic & Medicinal Chemistry

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Europe PubMed Central

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29 November 2017

10

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Europe PubMed Central

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29 November 2017

8

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Europe PubMed Central

PubMed publication ID

29 November 2017

2739-2749

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Europe PubMed Central

PubMed publication ID

29 November 2017

Subcloning, characterization, and affinity labeling of Escherichia coli glycinamide ribonucleotide transformylase.

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900102-5

7 January 2021

based on heuristic

inferred from DOI database lookup

Active-site mapping and site-specific mutagenesis of glycinamide ribonucleotide transformylase from Escherichia coli

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900102-5

7 January 2021

based on heuristic

inferred from DOI database lookup

De novo purine nucleotide biosynthesis: cloning of human and avian cDNAs encoding the trifunctional glycinamide ribonucleotide synthetase-aminoimidazole ribonucleotide synthetase-glycinamide ribonucleotide transformylase by functional complementatio

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900102-5

7 January 2021

based on heuristic

inferred from DOI database lookup

Cloning and characterization of a new purine biosynthetic enzyme: a non-folate glycinamide ribonucleotide transformylase from E. coli.

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900102-5

7 January 2021

based on heuristic

inferred from DOI database lookup

A multifunctional protein possessing glycinamide ribonucleotide synthetase, glycinamide ribonucleotide transformylase, and aminoimidazole ribonucleotide synthetase activities in de novo purine biosynthesis

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900102-5

7 January 2021

based on heuristic

inferred from DOI database lookup

Structural and mechanistic studies on the HeLa and chicken liver proteins that catalyze glycinamide ribonucleotide synthesis and formylation and aminoimidazole ribonucleotide synthesis

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900102-5

7 January 2021

based on heuristic

inferred from DOI database lookup

Multiple purine pathway enzyme activities are encoded at a single genetic locus in Drosophila

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Formyltetrahydrofolate hydrolase, a regulatory enzyme that functions to balance pools of tetrahydrofolate and one-carbon tetrahydrofolate adducts in Escherichia coli

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

The renewed potential for folate antagonists in contemporary cancer chemotherapy

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Synthesis of the antileukemic agents 5,10-dideazaaminopterin and 5,10-dideaza-5,6,7,8-tetrahydroaminopterin

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900102-5

7 January 2021

based on heuristic

inferred from DOI database lookup

Structural features of 5,10-dideaza-5,6,7,8-tetrahydrofolate that determine inhibition of mammalian glycinamide ribonucleotide formyltransferase

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900102-5

7 January 2021

based on heuristic

inferred from DOI database lookup

N10-substituted 5,8-dideazafolate inhibitors of glycinamide ribonucleotide transformylase

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900102-5

7 January 2021

based on heuristic

inferred from DOI database lookup

Synthesis and antitumor activity of 5-deaza-5,6,7,8-tetrahydrofolic acid and its N10-substituted analogues

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900102-5

7 January 2021

based on heuristic

inferred from DOI database lookup

Synthesis and biological activity of an acyclic analogue of 5,6,7,8-tetrahydrofolic acid, N-[4-[[3-(2,4-diamino-1,6-dihydro-6-oxo-5- pyrimidinyl)propyl]amino]-benzoyl]-L-glutamic acid

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900102-5

7 January 2021

based on heuristic

inferred from DOI database lookup

Synthesis and biological activity of open-chain analogues of 5,6,7,8-tetrahydrofolic acid--potential antitumor agents

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900102-5

7 January 2021

based on heuristic

inferred from DOI database lookup

A dideazatetrahydrofolate analogue lacking a chiral center at C-6, N-[4-[2-(2-amino-3,4-dihydro-4-oxo-7H-pyrrolo[2,3-d]pyrimidin-5- yl)ethyl]benzoyl]-L-glutamic acid, is an inhibitor of thymidylate synthase

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900102-5

7 January 2021

based on heuristic

inferred from DOI database lookup

Synthesis and antifolate evaluation of 10-ethyl-5-methyl-5,10- dideazaaminopterin and an alternative synthesis of 10-ethyl-10- deazaaminopterin (edatrexate)

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900102-5

7 January 2021

based on heuristic

inferred from DOI database lookup

Synthesis and biological activity of acyclic analogues of 5,10-dideaza-5,6,7,8-tetrahydrofolic acid

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900102-5

7 January 2021

based on heuristic

inferred from DOI database lookup

Design and synthesis of inhibitors of folate-dependent enzymes as antitumor agents.

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900102-5

7 January 2021

based on heuristic

inferred from DOI database lookup

Analogues of 10-deazaaminopterin and 5-alkyl-5,10-dideazaaminopterin with the 4-substituted 1-naphthoyl group in the place of 4-substituted benzoyl

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900102-5

7 January 2021

based on heuristic

inferred from DOI database lookup

Protein structure-based design, synthesis, and biological evaluation of 5-thia-2,6-diamino-4(3H)-oxopyrimidines: potent inhibitors of glycinamide ribonucleotide transformylase with potent cell growth inhibition

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900102-5

7 January 2021

based on heuristic

inferred from DOI database lookup

Multiple folate enzyme inhibition: mechanism of a novel pyrrolopyrimidine-based antifolate LY231514 (MTA).

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900102-5

7 January 2021

based on heuristic

inferred from DOI database lookup

A multisubstrate adduct inhibitor of AICAR transformylase

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900102-5

7 January 2021

based on heuristic

inferred from DOI database lookup

The synthesis and biological activity of a series of 2,4-diaminopyrido[2,3-d]pyrimidine based antifolates as antineoplastic and antiarthritic agents

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900102-5

7 January 2021

based on heuristic

inferred from DOI database lookup

Synthesis and biological activity of 4-amino-7-oxo-substituted analogues of 5-deaza-5,6,7,8-tetrahydrofolic acid and 5,10-dideaza-5, 6,7,8-tetrahydrofolic acid

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Folylpoly-gamma-glutamates as cosubstrates of 10-formyltetrahydrofolate:5'-phosphoribosyl-5-amino-4-imidazolecarboxamide formyltransferase

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900102-5

7 January 2021

based on heuristic

inferred from DOI database lookup

The human purH gene product, 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase. Cloning, sequencing, expression, purification, kinetic analysis, and domain mapping

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900102-5

7 January 2021

based on heuristic

inferred from DOI database lookup

De novo purine nucleotide biosynthesis: cloning, sequencing and expression of a chicken PurH cDNA encoding 5-aminoimidazole-4-carboxamide-ribonucleotide transformylase-IMP cyclohydrolase

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900102-5

7 January 2021

based on heuristic

inferred from DOI database lookup

Nucleotide sequence analysis of purH and purD genes from Salmonella typhimurium

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

5-Aminoimidazole-4-carboxamide ribotide transformylase-IMP cyclohydrolase from human CCRF-CEM leukemia cells: purification, pH dependence, and inhibitors.

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

On the purification and mechanism of action of 5-aminoimidazole-4-carboxamide-ribonucleotide transformylase from chicken liver

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

10-Formyl-5,8,10-trideazafolic acid (10-formyl-TDAF): a potent inhibitor of glycinamide ribonucleotide transformylase

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900102-5

7 January 2021

based on heuristic

inferred from DOI database lookup

Functionalized analogues of 5,8,10-trideazafolate as potential inhibitors of GAR Tfase or AICAR Tfase

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900102-5

7 January 2021

based on heuristic

inferred from DOI database lookup

Functionalized analogues of 5,8,10-trideazafolate: development of an enzyme-assembled tight binding inhibitor of GAR Tfase and a potential irreversible inhibitor of AICAR Tfase

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900102-5

7 January 2021

based on heuristic

inferred from DOI database lookup

Abenzyl 10-formyl-trideazafolic acid (abenzyl 10-formyl-TDAF): an effective inhibitor of glycinamide ribonucleotide transformylase

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900102-5

7 January 2021

based on heuristic

inferred from DOI database lookup

Multisubstrate analogue based on 5,8,10-trideazafolate

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900102-5

7 January 2021

based on heuristic

inferred from DOI database lookup

Design, synthesis, and evaluation of potential GAR and AICAR transformylase inhibitors.

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Conformationally restricted analogues designed for selective inhibition of GAR Tfase versus thymidylate synthase or dihydrofolate reductase

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Design, synthesis, and biological evaluation of fluoronitrophenyl substituted folate analogues as potential inhibitors of GAR transformylase and AICAR transformylase

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

A multisubstrate adduct inhibitor of a purine biosynthetic enzyme with a picomolar dissociation constant

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Multisubstrate adduct inhibitors of glycinamide ribonucleotide transformylase: Synthetic and enzyme-assembled

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900102-5

7 January 2021

based on heuristic

inferred from DOI database lookup

Induction of HL-60 leukemia cell differentiation by tetrahydrofolate inhibitors of de novo purine nucleotide biosynthesis

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

In vivo antitumor activity and metabolism of a series of 5-deazaacyclotetrahydrofolate (5-DACTHF) analogues

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Effect of purine synthesis inhibition on WiDr spheroids in vitro or on WiDr or colon 38 tumors in vivo. Complete growth inhibition but not regression.

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Applications of N,N-dimethylhydrazones to synthesis. Use in efficient, positionally and stereochemically selective CC bond formation; oxidative hydrolysis to carbonyl compounds

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Herstellung und synthetische Verwendung von metallierten Dimethylhydrazonen Regio- und stereoselektive Alkylierung von Carbonylverbindungen

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Synthesewege zu polyfunktionellen Molekülen über metallierte Dimethylhydrazone

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Synthetic peptides including acidic clusters as substrates of yeast casein kinase-2.

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900102-5

7 January 2021

based on heuristic

inferred from DOI database lookup

Strength of an interloop hydrogen bond determines the kinetic pathway in catalysis by Escherichia coli dihydrofolate reductase

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1016/S0968-0896(02)00102-5

1 reference

Europe PubMed Central

PubMed publication ID

29 November 2017

release_aojyjq2yznhxfbul66fdbrdx44

1 reference

https://api.fatcat.wiki/v0/release/aojyjq2yznhxfbul66fdbrdx44

24 November 2022

based on heuristic

mapped directly with Wikidata item

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

29 November 2017

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