(Q44023078)

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Selective, reversible caspase-3 inhibitor is neuroprotective and reveals distinct pathways of cell death after neonatal hypoxic-ischemic brain injury

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Europe PubMed Central

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29 November 2017

Selective, reversible caspase-3 inhibitor is neuroprotective and reveals distinct pathways of cell death after neonatal hypoxic-ischemic brain injury (English)

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Europe PubMed Central

PubMed publication ID

29 November 2017

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David M. Holtzman

15

object named as

David M Holtzman

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29 November 2017

author name string

Byung Hee Han

1

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29 November 2017

Daigen Xu

2

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29 November 2017

Junjeong Choi

3

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29 November 2017

Yongxin Han

4

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29 November 2017

Steven Xanthoudakis

5

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29 November 2017

Sophie Roy

6

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29 November 2017

John Tam

7

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29 November 2017

John Vaillancourt

8

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29 November 2017

John Colucci

9

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29 November 2017

Robert Siman

10

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29 November 2017

Andre Giroux

11

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29 November 2017

George S Robertson

12

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29 November 2017

Robert Zamboni

13

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29 November 2017

Donald W Nicholson

14

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29 November 2017

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publication date

10 June 2002

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29 November 2017

Journal of Biological Chemistry

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29 November 2017

277

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29 November 2017

33

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29 November 2017

30128-30136

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29 November 2017

Experimental biology of cerebral hypoxia-ischemia: relation to perinatal brain damage

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202931200

21 January 2018

Selective sparing of NADPH-diaphorase neurons in neonatal hypoxia-ischemia

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202931200

21 January 2018

Implication of cysteine proteases calpain, cathepsin and caspase in ischemic neuronal death of primates

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202931200

21 January 2018

Clusterin contributes to caspase-3-independent brain injury following neonatal hypoxia-ischemia.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202931200

21 January 2018

Early Neurodegeneration after Hypoxia-Ischemia in Neonatal Rat Is Necrosis while Delayed Neuronal Death Is Apoptosis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202931200

21 January 2018

Caspase inhibitor affords neuroprotection with delayed administration in a rat model of neonatal hypoxic-ischemic brain injury

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202931200

21 January 2018

Inhibition of interleukin 1beta converting enzyme family proteases reduces ischemic and excitotoxic neuronal damage

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202931200

21 January 2018

The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1 beta-converting enzyme

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202931200

21 January 2018

Caspases: enemies within

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202931200

21 January 2018

Suicidal tendencies: apoptotic cell death by caspase family proteinases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202931200

21 January 2018

Caspases: key players in programmed cell death

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202931200

21 January 2018

Inhibition of human caspases by peptide-based and macromolecular inhibitors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202931200

21 January 2018

Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202931200

21 January 2018

In situ immunodetection of activated caspase-3 in apoptotic neurons in the developing nervous system

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202931200

21 January 2018

Synergistic activation of caspase-3 by m-calpain after neonatal hypoxia-ischemia: a mechanism of "pathological apoptosis"?

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202931200

21 January 2018

Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202931200

21 January 2018

Caspase-dependent cleavage of signaling proteins during apoptosis. A turn-off mechanism for anti-apoptotic signals

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202931200

21 January 2018

Multiple-label immunocytochemistry for the evaluation of nature of cell death in experimental models of neurodegeneration.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202931200

21 January 2018

Molecular ordering of the Fas-apoptotic pathway: the Fas/APO-1 protease Mch5 is a CrmA-inhibitable protease that activates multiple Ced-3/ICE-like cysteine proteases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202931200

21 January 2018

FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death--inducing signaling complex

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202931200

21 January 2018

Pro-caspase-3 is a major physiologic target of caspase-8.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202931200

21 January 2018

Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202931200

21 January 2018

Caspase cleaved BID targets mitochondria and is required for cytochrome c release, while BCL-XL prevents this release but not tumor necrosis factor-R1/Fas death

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202931200

21 January 2018

Ordering the cytochrome c-initiated caspase cascade: hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202931200

21 January 2018

Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202931200

21 January 2018

Mitochondria and apoptosis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202931200

21 January 2018

BCL-2 family members and the mitochondria in apoptosis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202931200

21 January 2018

mu-Calpain activation, DNA fragmentation, and synergistic effects of caspase and calpain inhibitors in protecting hippocampal neurons from ischemic damage.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202931200

21 January 2018

Marked age-dependent neuroprotection by brain-derived neurotrophic factor against neonatal hypoxic-ischemic brain injury.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202931200

21 January 2018

An ELISA for detection of apoptosis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202931200

21 January 2018

Caspase inhibitors improve survival in sepsis: a critical role of the lymphocyte

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202931200

21 January 2018

Calpain and caspase: can you tell the difference?

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202931200

21 January 2018

Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202931200

21 January 2018

Caspase-2 activation is redundant during seizure-induced neuronal death

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202931200

21 January 2018

Apoptosis in a neonatal rat model of cerebral hypoxia-ischemia.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202931200

21 January 2018

Cdc42 is a substrate for caspases and influences Fas-induced apoptosis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202931200

21 January 2018

Identification and mapping of Casp7, a cysteine protease resembling CPP32 beta, interleukin-1 beta converting enzyme, and CED-3.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202931200

21 January 2018

N-terminal cleavage of bax by calpain generates a potent proapoptotic 18-kDa fragment that promotes bcl-2-independent cytochrome C release and apoptotic cell death.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202931200

21 January 2018

Cleavage of Bax is mediated by caspase-dependent or -independent calpain activation in dopaminergic neuronal cells: protective role of Bcl-2.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202931200

21 January 2018

Bid is cleaved by calpain to an active fragment in vitro and during myocardial ischemia/reperfusion

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202931200

21 January 2018

Cross-talk between two cysteine protease families. Activation of caspase-12 by calpain in apoptosis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202931200

21 January 2018

Involvement of caspase-3 in cell death after hypoxia-ischemia declines during brain maturation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202931200

21 January 2018

The influence of immaturity on hypoxic‐ischemic brain damage in the rat

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202931200

21 January 2018

Neurotransmitter alterations in a model of perinatal hypoxic-ischemic brain injury

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202931200

21 January 2018

BDNF blocks caspase-3 activation in neonatal hypoxia-ischemia

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202931200

21 January 2018

Caspase inhibitors reduce neuronal injury after focal but not global cerebral ischemia in rats

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202931200

21 January 2018

Purification and catalytic properties of human caspase family members

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202931200

21 January 2018

Nerve growth factor protects the neonatal brain against hypoxic-ischemic injury

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202931200

21 January 2018

Substrate specificities of caspase family proteases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202931200

21 January 2018

Activation of calpain I converts excitotoxic neuron death into a caspase-independent cell death

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202931200

21 January 2018

Deficiency in caspase-9 or caspase-3 induces compensatory caspase activation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202931200

21 January 2018

Functional characterization of Jurkat T cells rescued from CD95/Fas-induced apoptosis through the inhibition of caspases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202931200

21 January 2018

Identifiers

10.1074/JBC.M202931200

1 reference

Europe PubMed Central

PubMed publication ID

29 November 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

29 November 2017

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