(Q44031815)

29 November 2017

Serine 577 is phosphorylated and negatively affects the tRNA binding and eIF2alpha kinase activities of GCN2. (English)

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29 November 2017

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Minerva Garcia-Barrio

1

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29 November 2017

Jinsheng Dong

2

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29 November 2017

Vera A Cherkasova

3

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29 November 2017

Xiaolong Zhang

4

1 reference

29 November 2017

Fan Zhang

5

1 reference

29 November 2017

Sandra Ufano

6

1 reference

29 November 2017

Ruby Lai

7

1 reference

29 November 2017

Jun Qin

8

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29 November 2017

Alan G Hinnebusch

9

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29 November 2017

language of work or name

English

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publication date

17 June 2002

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Journal of Biological Chemistry

29 November 2017

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29 November 2017

277

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29 November 2017

30675-30683

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29 November 2017

34

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MAP kinase pathways in yeast: for mating and more

29 November 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203187200

Molecular cloning and mapping of the brain-abundant B1gamma subunit of protein phosphatase 2A, PPP2R2C, to human chromosome 4p16

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203187200

Transcriptional profiling shows that Gcn4p is a master regulator of gene expression during amino acid starvation in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203187200

Translation of the yeast transcriptional activator GCN4 is stimulated by purine limitation: implications for activation of the protein kinase GCN2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203187200

Glucose limitation induces GCN4 translation by activation of Gcn2 protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203187200

The protein kinase Gcn2p mediates sodium toxicity in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203187200

The histidyl-tRNA synthetase-related sequence in the eIF-2 alpha protein kinase GCN2 interacts with tRNA and is required for activation in response to starvation for different amino acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203187200

Histidyl-tRNA synthetase-related sequences in GCN2 protein kinase regulate in vitro phosphorylation of eIF-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203187200

Uncharged tRNA activates GCN2 by displacing the protein kinase moiety from a bipartite tRNA-binding domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203187200

Characterization of the hemin-sensitive eukaryotic initiation factor 2alpha kinase from mouse nonerythroid cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203187200

Regulated translation initiation controls stress-induced gene expression in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203187200

Dimerization by translation initiation factor 2 kinase GCN2 is mediated by interactions in the C-terminal ribosome-binding region and the protein kinase domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203187200

The tRNA-binding moiety in GCN2 contains a dimerization domain that interacts with the kinase domain and is required for tRNA binding and kinase activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203187200

Ribosome association of GCN2 protein kinase, a translational activator of the GCN4 gene of Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203187200

Ribosome-binding domain of eukaryotic initiation factor-2 kinase GCN2 facilitates translation control

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203187200

Juxtaposition of domains homologous to protein kinases and histidyl-tRNA synthetases in GCN2 protein suggests a mechanism for coupling GCN4 expression to amino acid availability

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203187200

Association of GCN1-GCN20 regulatory complex with the N-terminus of eIF2alpha kinase GCN2 is required for GCN2 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203187200

Separate domains in GCN1 for binding protein kinase GCN2 and ribosomes are required for GCN2 activation in amino acid-starved cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203187200

Budding yeast GCN1 binds the GI domain to activate the eIF2alpha kinase GCN2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203187200

GCN1, a translational activator of GCN4 in Saccharomyces cerevisiae, is required for phosphorylation of eukaryotic translation initiation factor 2 by protein kinase GCN2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203187200

Evidence that GCN1 and GCN20, translational regulators of GCN4, function on elongating ribosomes in activation of eIF2alpha kinase GCN2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203187200

Mutations activating the yeast eIF-2 alpha kinase GCN2: isolation of alleles altering the domain related to histidyl-tRNA synthetases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203187200

Atomic structure of the MAP kinase ERK2 at 2.3 A resolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203187200

Crystal structure of cyclin-dependent kinase 2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203187200

Phosphorylation modulates catalytic function and regulation in the cAMP-dependent protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203187200

Active and inactive protein kinases: structural basis for regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203187200

Autophosphorylation in the activation loop is required for full kinase activity in vivo of human and yeast eukaryotic initiation factor 2alpha kinases PKR and GCN2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203187200

Identification of positive-acting domains in GCN2 protein kinase required for translational activation of GCN4 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203187200

Effect of brain ischemia and reperfusion on the localization of phosphorylated eukaryotic initiation factor 2 alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203187200

Yeast translation initiation suppressor sui2 encodes the alpha subunit of eukaryotic initiation factor 2 and shares sequence identity with the human alpha subunit.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203187200

Identification of phosphorylation sites in proteins separated by polyacrylamide gel electrophoresis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203187200

Association of RAP1 binding sites with stringent control of ribosomal protein gene transcription in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203187200

Phosphorylation of initiation factor 2 alpha by protein kinase GCN2 mediates gene-specific translational control of GCN4 in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203187200

Homologous segments in three subunits of the guanine nucleotide exchange factor eIF2B mediate translational regulation by phosphorylation of eIF2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203187200

Vector systems for the expression, analysis and cloning of DNA sequences in S. cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203187200

Mutations that bypass tRNA binding activate the intrinsically defective kinase domain in GCN2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203187200

Genetic and biochemical evidence for yeast GCN2 protein kinase polymerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203187200

Coupling of GCN4 mRNA translational activation with decreased rates of polypeptide chain initiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203187200

21 January 2018

Identifiers

DOI

10.1074/JBC.M203187200

1 reference

29 November 2017

1 reference